EMBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2022
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:30–9:20 B22/116 aula
Prerequisites (in Czech)
EMBF0211c Biophysics - practice && EMBC0321s Biochemistry I - seminar && EMFY0321c Physiology I - practicals && EMFY0321s Physiology I - practicals
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course builds on Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand the biochemical processes characteristic of individual tissues and organs and the principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points out the connections between biochemical principles and other medical subjects, such as physiology, immunology, pharmacology, toxicology and others.
Learning outcomes
After completing the course, the student will be able to:
- explain the basic interrelationships between nutrient metabolism in different conditions of the organism
- describe the metabolic characteristics of major organs and tissues and major disorders
- understand the principles of maintaining homeostasis and acid-base balance
- discuss the composition of body fluids and its disorders in connection with the principles of homeostasis
- explain the principles of metabolism regulation at all levels
Syllabus
  • Plasma lipids. Lipoprotein metabolism.
  • Nutrient metabolism in different conditions.
  • Biochemical functions of the liver. Heme catabolism.
  • Iron and copper metabolism. Biotransformation of xenobiotics. Ethanol metabolism.
  • Homeostasis of water, Na + and K  + ions. Regulation of osmolality and volemia.
  • Acid-base balance. Transport O  2 and CO 2 through blood. Buffer bases.
  • Biochemical functions of the kidneys. Filtration functions. Tubular resorption and secretion.
  • Steroid and thyroid hormones.
  • Membrane and intracellular receptors. Nervous tissue metabolism. Neurotransmitters, synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine and iodine.
  • Vascular endothelium. Hemocoagulation, fibrinolysis.
  • Biochemistry of blood elements. The most important blood plasma proteins.
  • Extracellular matrix. Connective tissue metabolism.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Supplementary materials: https://is.muni.cz/auth/el/med/jaro2022/EMBC0422s/um/
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • BORON, Walter F. and Emile L. BOULPAEP. Medical physiology. Third edition. Philadelphia: Elsevier, 2017, xii, 1297. ISBN 9781455743773. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
Teaching methods
Lectures
Assessment methods
Oral exam - students will draw two questions from Biochemistry I and two from Biochemistry II.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2022/EMBC0422p/
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2022, recent)
  • Permalink: https://is.muni.cz/course/med/spring2022/EMBC0422p