EMBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Iva Audy (assistant)
Mgr. David Galuška (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 7:20–9:00 B22/116 aula
Prerequisites (in Czech)
EMBF0211c Biophysics - practice && EMBC0321s Biochemistry I - seminar && EMFY0321c Physiology I - practicals && EMFY0321s Physiology I - practicals
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course builds on Biochemistry I and deals with the integration of biochemical processes in the human body. The aim is to understand the biochemical processes characteristic of individual tissues and organs and the principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points out the connections between biochemical principles and other medical subjects, such as physiology, immunology, pharmacology, toxicology and others.
Learning outcomes
After completing the course, the student will be able to:
- explain the basic interrelationships between nutrient metabolism in different conditions of the organism
- describe the metabolic characteristics of major organs and tissues and major disorders
- understand the principles of maintaining homeostasis and acid-base balance
- discuss the composition of body fluids and its disorders in connection with the principles of homeostasis
- explain the principles of metabolism regulation at all levels
Syllabus
  • Blood plasma lipids. Metabolism of lipoproteins.
  • Overview of nutrient metabolism in different states.
  • Metabolic functions of liver. Catabolism of heme. Biochemical tests for liver diseases.
  • Metabolism of iron and copper. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and Na+, K+ ions balance, osmolality and volume of ECF.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases. Parameters of acid-base status.
  • Biochemical functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • General mechanisms of action of signal molecules. Hormone receptors.
  • Steroid and thyroid hormones.
  • Nervous tissue. Cerebrospinal fluid. Neurosecretion. Neurotransmitters and their receptors.
  • Endothelial cells. Blood-coagulation cascade, inhibition of clotting. Fibrinolysis.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Bone tissue. Articular cartilage and skin.
  • Biochemistry of blood cells. Major proteins of blood plasma.
Literature
    required literature
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Translated by Vladimír Benda - Martin Vejražka - Jiří Jonák. 1. české vydání. Praha: Grada, 2012, xiv, 498. ISBN 9788024729770. info
  • VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Úvod do všeobecnej a klinicky aplikovanej biochémie. Edited by Jozef Čársky. Prvé slovenské vydanie. Bratislava: Balneotherma s.r.o., 2015, 669 stran. ISBN 9788097015688. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu EMFY0422p.
  • SILBERNAGL, Stefan and Agamemnon DESPOPOULOS. Atlas fyziologie člověka. 6. vyd., zcela přeprac. a r. Praha: Grada, 2004, xiii, 435. ISBN 802470630X. info
Teaching methods
Lectures
Assessment methods
Oral exam. Student draws two questions from Biochemistry I and two questions from Biochemistry II. The student answers the questions without preparation.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů: EMBC0422s a EMBC0422c.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/1411/jaro2024/EMBC0422p/
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MUNI.
The course is also listed under the following terms spring 2022, spring 2023, spring 2025.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/spring2024/EMBC0422p