VLKF091p Applied Clinical Pharmacology

Faculty of Medicine
spring 2025
Extent and Intensity
2/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
Mgr. Kristýna Nosková, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
MUDr. Filip Šiška (lecturer)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
VLFA08222p Pharmacology II - lecture
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to understand the basic principles of individualization of pharmacotherapy, guaranteeing its safety and efficacy, including adjustments of drug dosages in the insufficiency of elimination organs. The course also focuses on the applied and clinical pharmacology of selected drug groups, with emphasis on working with drug information, reasonable prescribing, applied kinetics, and drug interaction management. The course is delivered as interactive seminars in which virtual patients will be discussed. Active knowledge of general and special pharmacology, including mechanisms of action of the essential drug groups, is a prerequisite. This course is a follow-up to Pharmacology I and II in the 7th/8th semester of the General Medicine curriculum.
Learning outcomes
Upon completion of the course, the student will be able to:
- reasonably prescribe drugs and their combinations, be able to select the appropriate drug for a particular patient and prescribe it in the correct dose, correct regimen, including route of administration, correct indication and also with regard to possible side effects with special emphasis on the safety;
- understand and be able to explain the mechanisms of action of the most commonly prescribed drugs, explain clinically significant differences between drugs in a given group;
- evaluate current pharmacotherapy, optimize it and propose modification; calculate the correct doses of drugs for patients with elimination organ disorders or other comorbidities;
- involve the patient in co-decision-making regarding his/her pharmacotherapy;
- provide appropriate guidance and information on pharmacotherapy to the patient; educate the patient;
- design a method and regimen for monitoring the efficacy and safety of therapy;
- detect and report adverse drug reactions;
- work with and critically evaluate sources of information on drugs.
Syllabus
  • 1. Clinical pharmacology of analgesics, pain management
  • 2. Drug policy, reasonable prescribing
  • 3. Applied pharmacokinetics of antibiotics
  • 4. Drug interactions
  • 5. Clinical pharmacology of antihypertensives; drug-induced hypertension; hemodynamics and pharmacokinetics
  • 6. Clinical pharmacology of diuretics, therapy of mineral dysbalances
  • 7. Applied pharmacology of antithrombotic
  • 8. Clinical trial interpretation, EBM, and critical thinking
  • 9. Clinical pharmacology of antipsychotics
  • 10. Dose adjustment in renal insufficiency, nephrotoxicity of drugs
  • 11. Clinical pharmacology of antiepileptic
  • 12. Principles of drug dosing in patients with hepatic insufficiency
  • 13. Clinical pharmacology of targeted therapy in oncology
  • 14. Therapy of symptoms associated with cancer treatment
  • 15. Perioperative drug management
Literature
    recommended literature
  • Vybrané kapitoly z klinické farmakologie. Rychlíčková J., Součková L., a kol. – dostupné v IS
  • Clinical pharmacology. Brown M.J., Sharma P., et al. 12th ed. London: Elsevier, 2019. 706 p. ISBN 978-0-7020-7328-1.
Teaching methods
Lecture
Assessment methods
Compulsory attendance at seminars (2 unexcused absences allowed), credit, and written exam in the form of a 25-question multiple-choice test, but only one answer is always correct. A minimum of 15 correct answers (60%) is required for successful completion.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: in blocks.
Information on the extent and intensity of the course: 30.
Teacher's information
The course may be completed outside of the examination period. The course is taught annually. The course is taught in blocks throughout the semester.
The course is also listed under the following terms autumn 2024.
  • Enrolment Statistics (spring 2025, recent)
  • Permalink: https://is.muni.cz/course/med/spring2025/VLKF091p