BZFA0321 Pharmacology I

Faculty of Medicine
Autumn 2012
Extent and Intensity
1/2. 4 credit(s). Type of Completion: z (credit).
Teacher(s)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
prof. MUDr. Alexandra Šulcová, CSc. (alternate examiner)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (alternate examiner)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
Guaranteed by
prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 20 student(s).
Current registration and enrolment status: enrolled: 0/20, only registered: 0/20
Course objectives
From the course on pharmacology students are expected to obtain: a) from lectures and seminars: a clarification of integration in the field of biomedical subjects such as chemistry, physiology, molecular biology, pathology and pathological physiology enabling them to understand why, what mechanism by, and what conditions on, drugs and their combinations may elicit therapeutic, adverse, and toxic effects. They will acquire an orientation in drug classes according to their main therapeutic indications with an attention paid to common drug-drug interactions, too. Information on drug development process, rules of preclinical and clinical drug testing will also be given. b) from practicals: a training in practical skills in "pharmacological thinking" in cases of need to make a choice of drug, dosing regimen, rout and techniques of administration, and an elimination of adverse interactions with drugs simultaneously given.
Syllabus
  • LECTURES:
  • 1. Drug classification. Mechanisms of drug effects. Basic pharmacokinetics. Drug interactions.
  • 2. Adverse drug effects. General management of poisoning. Rationale pharmacotherapy. Preclinical and clinical drug evaluation.
  • 3. Anaestetics, analgesic drugs. Non-steroidal antiinflammatory drugs.
  • 4. Neurotropic drugs, psychotropic drugs. Drugs of abuse.
  • 5. Pharmacotherapy of hypertension, angina pectoris, hyperlipidemia, heart failure and heart arrhythmias. Diuretics.
  • 6. Pharmacology of allergy. Histamine and antihistamine drugs. Drugs used in asthma
  • 7. Pathophysiology and therapy of diabetes mellitus. Insulines. Peroral antidiabetic drugs. Glucocorticoids, mechanism of effect.
  • 8. Antibiotics and chemoterapeutics, antiviral agents, antimycotic agents, antiprotozoic agents.
  • 9. Pharmacotherapy of neoplastic diseases. Imunomodulation, imunosupression.
  • SEMINARS:
  • 1. Introduction to the study of pharmacology. Contents and organisation of practical courses. Pharmacological calculations. Latin terminology in the drug prescription
  • 2. Drug prescription. Survey of drug dosage forms. Pharmacopoea.
  • 3. Practical preparation of selected drug dosage forms.
  • 4. Experimental pharmacology. Etics of experiments in lab animals.
  • 5. Pharmacokinetic processes and parameters. Therapeutic drug monitoring. The use of computer techiques in pharmacokinetics. Practical computations of basic pharmacokinetic parameters.
  • 6. Pharmacology of autonomic nervous system. Receptors of sympathetic system and their pharmacological influence.
  • 7. Pharmacology of autonomic nervous system. Receptors of parasympathetic system and their pharmacological influence.
  • 8. Pharmacology of allergy. Histamine and antihistamine drugs. Drugs used in asthma
  • 9. Antiflogistic and antiarthritic drugs, drugs used in gout.
  • 10. Pathophysiology and therapy of peptic ulcers. Antiemetics.
  • 11. Pathophysiology and therapy of diabetes mellitus. Insulines. Peroral antidiabetic drugs.
  • 12. Glucokorticoids, mechanism of effect. Anabolic drugs.
  • 13. Pharmacotherapy of neoplastic diseases. Imunomodulation, imunosupression.
  • 14. Vitamins B, C, A, D, E, K. Supplements.
  • 15. Revision, test, credits.
Literature
  • Martínková, Jiřina. Farmakologie. Pro studenty zdravotnických oborů, Grada Publishing, 2007. 380 s. ISBN 978-80-247-1356-4
  • František, Perlík. Základy farmakologie.Klinická a speciální farmakologie. 1. vyd. Praha: Galén a Univerzita Karlova v Praze (Karolinum), 2005. 190 s. ISBN 80-7262-374-5 (Galén), ISBN 80-246-1139-2 (Karolinum).
  • MACH, Ivan. Doplňky stravy na našem trhu. Vyd. 1. Praha: Svoboda Servis, 2006, 118 s. ISBN 8086320464. info
  • LÜLLMANN, Heinz. Barevný atlas farmakologie. 2., přeprac. a dopl. vyd. Praha: Grada, 2001, 382 s. ISBN 807169973X. info
  • HYNIE, Sixtus. Farmakologie v kostce. 2., přeprac. vyd. V Praze: Triton, 2001, 520 s. ISBN 8072541811. info
  • HYNIE, Sixtus. Farmakologie pro bakalářské studium. 2. přeprac. vyd. Praha: Karolinum, 1996, 272 s. ISBN 8071841846. info
  • HYNIE, Sixtus. Farmakologie pro bakalářské studium. 2. přeprac. vyd. Praha: Karolinum, 1996, s. i-x. ISBN 8071841854. info
  • ýběr z učebnice pro střední zdravotnické školy, Neuwirth, Jiří. Klinická propedeutika. Praha : Avicenum, 1989 - k zapůjčení na Farmakologickém ústavu.
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
Assessment methods
During the studying the student has to prove active knowledge of pharmacology acquired to get the credit. The student has to pass the final written exam - multiple-choice test.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011.
  • Enrolment Statistics (recent)
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