LF:aVLBC0321c Biochemistry I - pract.

aVLBC0321c Biochemistry I - practice

Faculty of Medicine
Autumn 2017

Extent and Intensity

0/2/0. 3 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine

Timetable of Seminar Groups

aVLBC0321c/30: Fri 13:30–15:10 A16/213, H. Paulová
aVLBC0321c/31: Thu 14:00–15:40 A16/212, J. Dostál
aVLBC0321c/32: Thu 14:00–15:40 A16/216, J. Dostál
aVLBC0321c/33: Wed 14:00–15:40 A16/216, E. Táborská
aVLBC0321c/34: Fri 13:30–15:10 A16/216, H. Paulová
aVLBC0321c/35: Thu 16:00–17:40 A16/216, J. Tomandl
aVLBC0321c/36: Thu 16:00–17:40 A16/213, J. Tomandl
aVLBC0321c/37: Wed 14:00–15:40 A16/212, E. Táborská
aVLBC0321c/38: Fri 13:30–15:10 A16/216, J. Slanina

Prerequisites (in Czech)

aVLBI0222c Biology II - pract. && aVLBF011c Biophysics - pract.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

Seminars and exercises have a common content and serve for active practice of the subject matter in Biochemistry I. The aim of the course is to obtain knowledge on essential metabolic processes on the cellular level. Understanding of these proceses is a base for comprihension of metabolism on the tissue and organ level. In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemichal pathways in cells.

Learning outcomes

In the end of the course will students understand the meaning of basic chemical terms (pH, osmolality, electrolyte, buffer, etc.) and apply this knowledge when describing the properties of body fluids.
Describe the role of macro- and microbiogenic elements in the organism
Discusse the properties and function of enzymes
Describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
Understand the principles of energy production, utilization and deposition at the cellular level.
Explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
Describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understand the relationship between protein structure and function.
Explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
Discusses the principles of some diseases at the molecular level.

Syllabus

Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell, compartmentation of metabolic processes, non-covalent interactions). Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types. Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition. Coenzymes, their relationship to vitamins. Written test I (Biochemical methods, haemoglobin, enzymology, coenzymes.) Membrane structure and assembly. Transport across membranes. Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance. Important reactions in amino acid catabolism. Written test II (Membranes, transport across membranes, metabolism of saccharides and amino acids.) Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols. Metabolism of phospholipids. Biosynthesis of eicosanoids. Peroxidation of lipids. Written test III (Metabolism of lipids.) The citric acid cycle. The respiratory chain and oxidative phosphorylation. Replication, transcription, proteosynthesis.

Literature

required literature

Seminar texts available in Information system

Teaching methods

Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.

Assessment methods

Full attendance in lessons is the principal condition. If any absence, it must be apologized through Office of studies. If apology is recorded in Information System, then student is allowed to make up the absence according to teacher's instructions.

Language of instruction

English

Further Comments

The course is taught annually.

The course is also listed under the following terms Autumn 2016, autumn 2018, autumn 2019, autumn 2020.

Enrolment Statistics (Autumn 2017, recent)
Permalink: https://is.muni.cz/course/med/autumn2017/aVLBC0321c

LF:aVLBC0321c Biochemistry I - pract. - Course Information

aVLBC0321c Biochemistry I - practice

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