BLKH0311p Clinical Haematology - lecture

Faculty of Medicine
autumn 2018
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Ludmila Bourková (lecturer)
doc. MUDr. Milan Dastych, CSc., MBA (lecturer)
MUDr. Jarmila Kissová, Ph.D. (lecturer)
MUDr. Jana Michalcová (lecturer)
prof. MUDr. Miroslav Penka, CSc. (lecturer)
MUDr. Petr Smejkal, Ph.D. (lecturer)
RNDr. Jiřina Zavřelová (lecturer)
Michaela Gregorovičová (assistant)
Guaranteed by
prof. MUDr. Miroslav Penka, CSc.
Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Contact Person: MUDr. Alena Buliková, Ph.D.
Supplier department: Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Timetable
Thu 27. 9. 15:00–16:40 B11/234, Thu 4. 10. 15:00–16:40 B11/234, Thu 11. 10. 15:00–16:40 B11/234, Thu 18. 10. 15:00–16:40 B11/234, Thu 25. 10. 15:00–16:40 B11/234, Thu 1. 11. 15:00–16:40 B11/234, Thu 8. 11. 15:00–16:40 B11/234, Thu 15. 11. 15:00–16:40 B11/234, Thu 22. 11. 15:00–16:40 B11/234, Thu 29. 11. 15:00–16:40 B11/234, Thu 6. 12. 15:00–16:40 B11/234, Thu 13. 12. 15:00–16:40 B11/234, Thu 20. 12. 15:00–16:40 B11/234
Prerequisites
BLMB011p Mol.andCell.Biol.-lect. || PřF:Bi1700 Cell Biology
Basic principles of laboratory work. Human physiology and pathophysilogy concerning to hemopoesis, blood composition, blood cells and blood coagulation and hemostasis.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
This course includes information about the origin, development, structure and function of the system of hematopoietic cells and organs as well as of the blood clotting system. Both of them are described not only in health but also during various diseases inherited and acquired. Students will receive information summarizing pathophysiologic mechanisms, clinical and mainly laboratory findings in hematologic diseases and laboratory assays serving for treatment’s maintenance. The knowledge will allow students to interpret results obtained during hematological laboratory examination for diagnosis establishing and/or for differential diagnoses.
Learning outcomes
Basic principles of hematologic assays, incl. good laboratory practice. Student is able to: -indentify basic types of blood elements of peripheral blood and bone marrow, -interpret findings CBC blood count, -provide basic coagulation assays, -interpret basic coagulation tests.
Syllabus
  • Origin and development of blood cells.
  • Basic principles of blood coagulation.
  • Plasmatic clotting factors, their physiology. Inherited bleeding disorders.
  • Primary hemostasis, platelet plug formation and its abnormalities.
  • Basic principles of anti-platelet therapy.
  • Inherited thrombophilias, anti-thrombotic treatment and its monitoring.
  • Acquired disorders of blood clotting.
  • Red cell disorders.
  • Myeloproliferative neoplasms.
  • Acute leukaemias.
  • Myelodyspastic syndrome.
  • Lymphoproliferative disorders.
  • Flow cytometry and molecular genetic assays for diagnosis of hematology diseases.
  • Therapeutic aphaeresis, basic principles of hemopoietic cells transplantation.
Literature
  • PECKA, Miroslav. Laboratorní hematologie v přehledu : fyziologie a patofyziologie krevní buňky. 1. vyd. Český Těšín: FINIDR, 2006, 304 s. ISBN 8086682021. info
  • PECKA, Miroslav. Laboratorní hematologie v přehledu : fyziologie a patofyziologie hemostázy. 1. vyd. Český Těšín: FINIDR, 2004, 237 s. ISBN 808668203X. info
  • PECKA, Miroslav. Přehled laboratorní hematologie. Bílá krevní řada, krevní destičky. [1. vyd.]. Praha: Galén, 1996, 132 s. ISBN 8085824434. info
  • Přehled laboratorní hematologie 1 :Krvetvorba. Červená krevní řada. Edited by Miroslav Pecka. [1. vyd.]. Praha: Galén, 1995, 141 s. ISBN 80-85824-28-0. info
Teaching methods
Students will attend two hours long lecture ones a week (14 per semester). Participation in lectures is optional. Each lecture is in the current version published on is.muni.cz.
Assessment methods
The course is closed by an examination which is divided into practical and an oral part. Practical part includes testing of haemostaseology or hematologic morphology, depending on the selected question. In the haemostaseology student performs basic coagulation test, interprets coagulation laboratory finding (four basic coagulation tests) and orally answers the selected question which is aimed at understanding the laboratory investigations in blood clotting. If the question is chosen from the morphological laboratory, the student evaluates 6 microscopic findings (in digital processing) and orally answers the selected question which is aimed at understanding the laboratory investigations in morphological diagnosis in haematology. In oral part student elects three questions, one of which is focused on non - oncological haematology, the second one concerns the blood coagulation and the third one at haematological oncology. Each question (one practical and three theoretical) is grades A-F. No grade F is necessary condition for passing an examination.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms Autumn 2006, Autumn 2007, Spring 2008, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2018, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2018/BLKH0311p