LF:aVLFA0721p Farmakologie I - přednáška

aVLFA0721p Farmakologie I - přednáška

Lékařská fakulta
podzim 2018

Rozsah

2/0/0. 30. 2 kr. Ukončení: k.

Vyučující

Garance

doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta

Rozvrh

Po 17. 9. až Pá 11. 1. Čt 18:00–19:40 KOM 200

Předpoklady

aVLPF0622c Patologická fyziol. II - cv && aVLPA0622c Patologie II - cv.

Omezení zápisu do předmětu

Předmět je nabízen i studentům mimo mateřské obory.

Mateřské obory/plány

Všeobecné lékařství (angl.) (program LF, M-VL)

Cíle předmětu

The aims of the course are:
to explain the basic pharmacodynamic and pharmacokinetic processes and principles
to explain the basic principles of therapy of intoxications
to describe the factors that influence the drug effect

Výstupy z učení

Student after the course:
knows basic pharmacodynamic principles
knowns basic pharmacokinetic principles
knows basic factors that influence the effect of drugs
is able to suggest therapeutic measures in case of drug intoxication

Osnova

VLFA07212c - Pharmacology I - Lectures

General medicine

Autumn semester 2018
1^st week
Topic: PHARMACOLOGY AND ITS SUB-BRANCHES
Course content: Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
2^nd week
Topic: OVERVIEW OF DRUG DOSAGE FORMS
Course content: Classification and overview of drug dosage forms for ready-made production and individual preparation, advantages and disadvantages of the particular types of drug dosage forms in clinical use, typical auxiliary substances (excipients). Drug dosage forms with controlled release.
3^rd week
Topic: ROUTES OF DRUG ADMINISTRATION
Course content: Classification of routes of administration, description of the individual ways with examples of drugs. Overview of innovative administration routes.
4^th week
Topic: PHARMACOKINETICS I
Course content: General principles of drug fate in the organism. Overview of the individual pharmacokinetic processes and parameters.
5^th week
Topic: PHARMACOKINETICS II
Course content: Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
6^th week
Topic: PHARMACODYNAMICS
Course content: Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
7^th week
Topic: DRUG SAFETY
Course content: Adverse drug effects - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
8^th week
Topic: FACTORS AFFECTING DRUG EFFECTS
Course content: Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenetics.
9^th week
Topic: PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
Course content: Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
10^th week
Topic: RESEARCH IN PHARMACOLOGY
Course content: Methods of experimental pharmacological research – brief overview. Examples from the Department of Pharmacology - Faculty of Medicine, MU.
11^th week
Topic: BASIC PRINCIPLES OF BIOLOGICAL THERAPY
Course content: Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use.
12^th week
Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
Course content: Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
13^th week
Topic: PHARMACOLOGY OF SEX HORMONES
Course content: Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
14^th week
Topic: ANALGESIC DRUGS
Course content: Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
15^th week
Topic: GENERAL AND LOCAL ANAESTHETIC AGENTS
Course content: Classification and pharmacological characteristics of general and local anaesthetic drugs.

Literatura

povinná literatura

Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
RANG, H. P., James RITTER, R. J. FLOWER a Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info

doporučená literatura

Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info

neurčeno

Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xii, 612. ISBN 9781451113143. info

Záložky

https://is.muni.cz/ln/tag/LF:aVLFA0721p!

Výukové metody

lectures, presentations by professionals in the sectors

Metody hodnocení

Colloquium - ROPOT test - 40 multiple-choice questions with 3 - 5 answer options. The number of correct answers is given.

Student gets 2 points for each completely correct answer, i.e. maximum 80 points for the whole multiple-choice test. Time limit: 60 min. The MCQ test can be repeated only twice.

To pass the colloquium successfully the student has to obtain at least 40 points.

Vyučovací jazyk

Angličtina

Informace učitele

Course Contents:

INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS
GENERAL RULES OF THE DRUG PRESCRIPTION
FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS
SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS
ROUTES OF DRUG ADMINISTRATION
INTRODUCTION TO PHARMACOKINETICS, PRINCIPLES, PARAMETERS
PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING
PHARMACODYNAMICS
ADVERSE DRUG REACTIONS
FACTORS AFFECTING DRUG EFFECTS
PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM SYMPATHOMIMETICS, SYMPATHOLYTICS
PHARMACOLOGY OF THE PARASYMPATHETIC NERVOUS SYSTEM CHOLINERGIC DRUGS, SPASMOLYTICS
PHARMACOLOGY OF ENDOCRINE SYSTEM
GLUCOCORTICOIDS
ANTI-DIABETIC DRUGS
SEX HORMONES, UTEROTONICS, TOCOLYTICS
ANALGESIC DRUGS
ANAESTHETIC DRUGS
PRINCIPLES OF BIOLOGICAL THERAPY

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LF:aVLFA0721p Farmakologie I - přednáška - Informace o předmětu

aVLFA0721p Farmakologie I - přednáška

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