LF:aVLPF0521p Pathol. physiology I - lecture - Course Information

aVLPF0521p Pathological Physiology I - lecture

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: z (credit).

Teacher(s)

prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
Věra Ježková (assistant)

Guaranteed by

prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine

Timetable

Tue 16:00–17:40 B11/334

Prerequisites (in Czech)

aVLFY0422c Physiology II - practice && aVLFY0422s Physiology II - seminar && aVLBC0422c Biochemistry II - pr. && aVLBC0422s Biochemistry II - sem && ( VLLM0421c Med.Microbiol. || aVLLM0421c Med.Microbiol. I - prac. ) && ( aVLFY0422p Physiology II - lecture || aVLBC0422p Biochemistry II - lect. )&& aVLHE0322c Histology and Embryology II -p && aVLAN0222c Anatomy II - dissection && aVLAN0222s Anatomy II - sem.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• General Medicine (eng.) (programme LF, M-VL)

Course objectives

The aim of the subject is to teach students to be able to answer a sufficient number of pathophysiologically asked questions "why", especially focused on these themes:
Pathological Physiology as a science. Disease, health, normality. Descriptivism contra normativism.
Physiology of genes, regulation of gene activity.
Monogenic and multigenic diseases.
Shock syndrome.
Reactive oxygen species (ROS). Ionising radiation effects on cellular level.
Ionising radiation effects on tissue and organismal level.
Cardiovascular pathophysiology - systolic and diastolic function.
Cardiac failure.
Myocardial ischemia.
Hypertension.
Pathophysiology of the gas exchange in the lungs.
Pathophysiology of respiratory mechanics.
Chronic obstructive bronchopulmonary disease.
Restriction pulmonary diseases, respiratory failure.
Physiology of membrane transports.

Learning outcomes

Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student discusses influences which determined population frequencies of alleles
Student distinguishes mutation types according to the mechanism
Student describes base principles of methods detecting human genome and its variability
Student summarises base types of DNA reparation
Student describes base characteristics of monogenic diseases
Student discusses base principles and indications of gene therapy
Student knows an importance of the term of pharmacogenetics
Student demonstrates understanding of an influence of external factors on disease development
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student is able to describe base principles of multicellular organism functioning
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing
Student knows pathophysiology of urgent states in oncology diseases
Student explains an importance of micronutrients abnormalities
Student knows results of abnormal vitamin levels
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes

Syllabus

• Pathophysiology: an integrating medical speciality. Aetiology and pathogenesis of diseases.
• Interaction of cells and intercellular communication, basic principles of intracellular signalling. Reaction of the cell on damage and hypoxia. Cell death. Cytokines network. Chemokines.
• Inflammation. Acute phase reaction. Systemic reaction of organism on damage. Regeneration and reparation. Wound healing.
• Hypertension. Remodelling of blood vessels. Diseases of peripheral blood vessels.
• Metabolism of myocardium, atherosclerosis, ischemic heart disease, myocardium infarction.
• Pathophysiology of malignant transformation.
• Stress
• Stress, general adaptation syndrome.
• Pathophysiology of gas exchange and ventilation control in the lungs.
• Lung diseases.
• Pathophysiological aspects of renal functions. Kidney diseases
• Acute and chronic renal failure.
• Pathophysiology of water and electrolytes. Tonicity and volume disturbances.
• Pathophysiological aspects of metabolism of calcium and phosphates, bone pathophysiology.

Literature

required literature
• NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. ISBN 80-246-0051-X. info
• NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, 379 s. ISBN 9788024606750. info
• NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
• Ivan Damjanov: Pathophysiology, ISBN 13: 978-1-4160-0229-1, Saunders Elsevier, 2009.

Teaching methods

lecture

Assessment methods

The attendance of lectures and only one absence on practicals per semester are necessary for succesfull accomplishment of the subject. Continous control of knowlledge in practicals is fully in powers of teachers (assays, tests...). Elaborated proceedings of practicals will be put to teachers for credit.

Language of instruction

English

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.

Teacher's information

http://www.med.muni.cz/patfyz

• Enrolment Statistics (autumn 2018, recent)
  
• Permalink: https://is.muni.cz/course/med/autumn2018/aVLPF0521p