EMLC0111p Medical chemistry - lecture

Faculty of Medicine
autumn 2020
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Mon 13:00–14:50 B11/334
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to provide knowledge of chemistry, which is necessary for the understanding of chemical principles applied in other subjects, especially in biochemistry. The student will learn about the properties of the solutions, and general physicochemical laws. The properties of elements and compounds of importance in medicine, nutrition and toxicology are presented. The subject should also provide an overview of the compounds and reactions involved in metabolism and toxicologically relevant organic compounds.
Learning outcomes
Student will be able to:
- apply general physicochemical laws to processes in living organisms.
- describe the properties of the most important biogenic elements and compounds important in medicine, nutrition and toxicology.
- describe and discuss the properties and reactions of organic and bioorganic compounds important for understanding biochemical processes.
Syllabus
  • Proteolytic reactions: basic concepts, polyhydric electrolytes, buffers, buffer systems in the organism.
  • Dispersion systems, diffusion, colligative properties, osmotic pressure. Colloidal solutions, dialysis. Surfactants.
  • Chemical thermodynamics, Gibbs energy. Chemical kinetics. Oxidation-reduction reactions, electrode potentials, relation to Gibbs energy change. Biochemically important redox systems. Precipitation reactions, insoluble compounds.
  • Biologically important elements and their compounds.
  • Biologically important reactions and relationships between organic compounds (redox reactions, transamination, citrate cycle).
  • Biologically important heterocyclic compounds (cofactors, vitamins, synthetic drugs, alkaloids, drugs).
  • Structure and properties of monosaccharides. Sugar derivatives. Oligosaccharides and homopolysaccharides. Heteropolysaccharides. Glycosides. Nucleosides and nucleotides. Nucleic acids.
  • Fatty acids, triacylglycerols. Phospholipids and glycolipids. Icosanoids. Terpenes. Steroids, calcium.
  • Coded amino acids, structure and general properties, polarity. Dependence of structure on pH. Peptides, various groups of biologically active peptides.
  • Essential features of the structure of globular, fibrillar and membrane proteins. Glycoproteins.
  • Nucleosides. Nucleotides. Nucleic acids.
Literature
Teaching methods
Lectures.
Assessment methods
Written examination consisting of two parts.
  • The first part is solved electronically: calculations of concentration, pH, osmotic pressure / osmolarity, simple questions requiring one-word answers or selection from the offered answers, recognition / naming of the mentioned compounds.
  • The second part is written: active drawing of structural formulas and equations, active answers to three thematic areas (general and inorganic chemistry, organic chemistry, static biochemistry). The questions concern the relevant chemical principles and their understanding.
    • Language of instruction
    Czech
    Further comments (probably available only in Czech)
    Study Materials
    Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů EMLC0111s.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    The course is also listed under the following terms autumn 2021, autumn 2022, autumn 2023, autumn 2024.
    • Enrolment Statistics (autumn 2020, recent)
    • Permalink: https://is.muni.cz/course/med/autumn2020/EMLC0111p