aVLBI0121p Medical Biology I - lecture

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (assistant)
Mgr. Kateřina Francová, Ph.D. (assistant)
Jana Růžičková (assistant)
Guaranteed by
prof. RNDr. Ondřej Slabý, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Ing. Lívia Eiselleová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Thu 16. 9. 8:00–9:40 B11/114, Thu 23. 9. 8:00–9:40 B11/114, Thu 30. 9. 8:00–9:40 B11/114, Thu 7. 10. 8:00–9:40 B11/114, Thu 14. 10. 8:00–9:40 B11/114, Thu 21. 10. 8:00–9:40 B11/114, Thu 4. 11. 8:00–9:40 B11/114, Thu 11. 11. 8:00–9:40 B11/114, Thu 18. 11. 8:00–9:40 B11/114, Thu 25. 11. 8:00–9:40 B11/114, Thu 2. 12. 8:00–9:40 B11/114, Thu 9. 12. 8:00–9:40 B11/114
Prerequisites
Knowledge of high-school biology on the level of Overview of High School Biology (https://is.muni.cz/auth/do/med/el/overview/overview_ENG.qwarp) or similar, and knowledge of all previous lectures and practical classes of the subject. Expected knowledge for each lecture is specified in the course syllabus. The literature recommended for each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of cellular and molecular biology with a special focus on the potential applications of acquired knowledge in clinical medicine
Learning outcomes
After completing the course the student will be able to:
- describe and explain the organization of prokaryotic and eukaryotic genome, DNA replication
- explain elementary processes taking place in cells (gene expression, inter- and intra-cellular communication, cell differentiation, cell division, cell death) and their purposes
- explain the relationship between malfunctioning of cellular processes and development of diseases
- explain how gene mutations and chromosome aberrations cause human diseases, and illustrate it with examples
Syllabus
  • Introduction to the Medical Biology
  • Fundamental Chemistry of Life – Chemical Components of Cells, Protein Structure and Function
  • Architecture and Function of Eukaryotic Cell – Membrane System and Organelles, Cytoskeletal System
  • Genome Organization – Nucleic Acids, Chromosome Structure, DNA replication
  • Genome Stability and Instability – DNA damage, Mutations, DNA repair and Defects in DNA repair
  • Gene Expression I – Central Dogma of Molecular Biology, Gene Structure, Transcription and RNA modification
  • Gene Expression II – Translation, Genetic Code, Post-translational Modifications
  • Regulation of Gene Expression
  • Cellular Communication – General Principles of Cell Signalling, Receptors, Signalling Pathways
  • Cell Cycle and Principles of its Regulation
  • Cell Division – Mitosis and Meiosis
  • Cell Death
  • Cells and Tissue – Cell Junctions, Adhesive Molecules and Extracellular Matrix
Literature
    required literature
  • Náhradní obsah: SNUSTAD, Peter D., Michael J. SIMMONS. Principles of Genetics. Sixth edition. Wiley, 2011, 784. ISBN 9780470903599
  • ALBERTS, Bruce, Karen HOPKIN, Alexander JOHNSON, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Essential cell biology. International student editio. New York: W.W Norton, 2019, xxxii, 734. ISBN 9780393680393. info
Teaching methods
lecture every week
Assessment methods
Without examination - Medical Biology I is continued with Medical Biology II which is completed with an oral exam.
Language of instruction
English
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 30.
Teacher's information
https://is.muni.cz/auth/el/1411/podzim2021/aVLBI0121p/index.qwarp
Lectures take place every week and are optional. We recommend to follow the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), and also corresponding study literature for each week, and links to animations and videos relevant to the topic (https://is.muni.cz/auth/el/1411/podzim2020/aVLBI0121p/index.qwarp)

The course is also listed under the following terms Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2021, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2021/aVLBI0121p