aVLPF0521c Pathophysiology I - practice

Lékařská fakulta
podzim 2021
Rozsah
0/3/0. 45. 4 kr. Ukončení: z.
Vyučující
MUDr. Vendula Bartáková, Ph.D. (cvičící)
MUDr. Kamil Ďuriš, Ph.D. (cvičící)
doc. MUDr. Jaromír Gumulec, Ph.D. (cvičící)
Mgr. Katarína Chalásová, Ph.D. (cvičící)
MUDr. Michal Jurajda, Ph.D. (cvičící)
prof. MUDr. Kateřina Kaňková, Ph.D. (cvičící)
Mgr. Andrea Knight, Ph.D. (cvičící)
MUDr. Jan Máchal, Ph.D. (cvičící)
prof. RNDr. Michal Masařík, Ph.D. (cvičící)
MUDr. Stanislav Matoušek, Ph.D. (cvičící)
MUDr. Petr Müller, Ph.D. (cvičící)
Mgr. Lukáš Pácal, Ph.D. (cvičící)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (cvičící)
Dipl. Ing. Martin Piskáček, Dr. rer. nat. (cvičící)
Mgr. Jana Šístková, Ph.D. (cvičící)
MUDr. Michal Šitina, Ph.D., M.Sc. (cvičící)
prof. MUDr. Anna Vašků, CSc. (cvičící)
Věra Ježková (pomocník)
Mgr. Šárka Lakomá (pomocník)
Mgr. Lucie Válková, Ph.D. (pomocník)
Garance
prof. MUDr. Kateřina Kaňková, Ph.D.
Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: prof. MUDr. Kateřina Kaňková, Ph.D.
Dodavatelské pracoviště: Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLPF0521c/30: Po 13. 9. až Pá 17. 12. Čt 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0521c/31: Po 13. 9. až Pá 17. 12. Čt 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0521c/32: Po 13. 9. až Pá 17. 12. Po 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0521c/33: Po 13. 9. až Pá 17. 12. Po 13:00–15:30 A18/112, M. Jurajda, J. Máchal
aVLPF0521c/34: Po 13. 9. až Pá 17. 12. Út 13:00–15:30 A18/112
aVLPF0521c/35: Po 13. 9. až Pá 17. 12. Út 13:00–15:30 A18/112
aVLPF0521c/36: Po 13. 9. až Pá 17. 12. St 13:00–15:30 A18/112
aVLPF0521c/37: St 13:00–15:30 A18/112
Předpoklady
aVLFY0422c Fyziologie II - cvičení && aVLFY0422s Fyziologie II - seminář && aVLBC0422c Biochemie II - cvičení && aVLBC0422s Biochemie II - sem. && ( VLLM0421c Lékařská mikrobiologie I-cvič. || aVLLM0421c Lékařská mikrobiologie I - cv. ) && ( aVLFY0422p Fyziologie II - přednáška || aVLBC0422p Biochemie II - předn. )&& aVLHE0322c Histologie a embryologie II -c && aVLAN0222c Anatomie II pitvy && aVLAN0222s Anatomie II - s
Physiology, biochemistry
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The student will be trained for assuming these knowledge and skills:
Principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals - explorative laparotomy
Pathophysiology of blood and bone marrow disorders, haematological findings in selected blood disorders
Statistical analysis of experiments (introduction)
Exp. induced acute radiation syndrome in lab. animal – haematological consequences
Essential hypertension, resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise
Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry and hyperoxic test
Secondary hypertension, exp. induced renal ischemia – quantification of renal rennin expression
Conductive disorders, demonstration of selected types of arrhythmias
ECG monitoring of exp. induced arrhythmias in lab. animal
Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion
Exp. induced renal failure - peritoneal dialysis in lab. animal
Výstupy z učení
: Student applies the basic knowledge of biostatistics to explain the structure of reference intervals
: Student will describe the influence of ionizing radiation on the body at the level of molecular, cellular, tissue, and they justify the time dynamics of the system
: Student will describe changes in blood cell counts dynamics in the acute radiation disease
: Student makes a distinction between deterministic and stochastic effects of ionizing radiation and their practical implications
: Student will explain the principle of ultrasound and dopplerometric examination of the blood vessels, the underlying pathology of peripheral vasculature (venous valvular insufficiency, ischemia, short circuits, and steal syndromes)
: Student interprets the continuous ECG monitoring in experimental animals for several pathological conditions
: Student distinguishes ECG records most commonly occurring arrhythmias (sinus arrhythmia, SVES, atrial fibrillation, atrial flutter, AVRT, AV blockade blockade, ventricular tachycardia, torsades de pointes, ventricular fibrillation)
: Student demonstrates the basic static and dynamic parameters surveyed during the spirometric examination and their relationship to pulmonary diseased
: Student will describe the development of renal ischemia in experimental animal model
: Student will explain the determination of the glomerular filtration rate, depending on the curve of concentration of inulin excretion by the kidneys, while discussing the use of clearance of other substances (creatinine, PAH)
: Student demonstrates the emergence of renovascular hypertension in the Goldblatt´s model, renal artery stenosis, the difference between unilateral and bilateral stenosis, the role of the RAAS and the expansion of the volume due to hypertension diagnosis
Osnova
  • Introduction, health & safety in the lab. Principles and demonstration of peripheral blood flow examination using ultrasonography. Training of techniques for experimental practice
  • Interindividual variability (tutorial). Training of techniques for experimental practice
  • Principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals & explorative laparotomy
  • Principles of ECG analysis, demonstration of selected pathological ECG patterns
  • Conductive disorders (seminar), ECG monitoring of exp. induced arrhythmias in lab. animal
  • Exp. induced renal ischemia (part 1)
  • Pathophysiological principles of oxygenotherapy and mechanical ventilation
  • Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry.
  • Exp. induced renal ischemia – detection of renal renin expression (part 2)
  • Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion Cell cycle, oncogenes and suppressor genes, cancer development. (tutorial)
  • Genetic susceptibility to disease – monogenic vs. complex diseases (tutorial)
  • Statistical analysis of experiments (introduction).
  • Tests, credits.
Literatura
Výukové metody
practical exercises in labs, discussion to the given topics, video with comments
Metody hodnocení
Practicals are compulsory. The only permited reason for not attending is a student's sick leave. Student can - with tutor's approval - substitute the particular practical in a given week with another group in case he/she has a justifiable reason for it. Student's participation in the practicals throughout the term is certified by a credit. Students can be given written tests or individual home work by tutor's throughout the term. Students have to be wearing lab coats during the practicals.
Vyučovací jazyk
Angličtina
Další komentáře
Studijní materiály
Předmět je vyučován každoročně.
Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2022, podzim 2023, podzim 2024.