aZLFA0722p Farmakologie II - přednáška

Lékařská fakulta
podzim 2023
Rozsah
1/0/0. 15. 2 kr. Ukončení: zk.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (přednášející)
doc. PharmDr. Jan Juřica, Ph.D. (přednášející)
Mgr. Petra Amchová, Ph.D. (přednášející)
doc. RNDr. Ladislava Bartošová, Ph.D. (přednášející)
Mgr. Jana Kubátová, Ph.D. (přednášející)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (přednášející)
MUDr. Alena Máchalová, Ph.D. (přednášející)
Mgr. Kristýna Nosková, Ph.D. (přednášející)
MUDr. Jana Nováková, Ph.D. (přednášející)
MUDr. Jana Pistovčáková, Ph.D. (přednášející)
PharmDr. Jitka Rychlíčková, Ph.D. (přednášející)
Mgr. Barbora Říhová, Ph.D. (přednášející)
PharmDr. Lenka Součková, Ph.D. (přednášející)
Renata Bláblová (pomocník)
Mgr. Marta Vyoralová (pomocník)
Carlos Daniel Ferreira Fonseca, MSc. (pomocník)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Dodavatelské pracoviště: Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Út 3. 10. 14:00–15:40 C15/311, Út 10. 10. 14:00–15:40 C15/311, Út 17. 10. 14:00–15:40 C15/311, Út 24. 10. 14:00–15:40 viz studijní materiály/see study materials, Út 31. 10. 14:00–15:40 viz studijní materiály/see study materials, Út 7. 11. 14:00–15:40 viz studijní materiály/see study materials, Út 14. 11. 14:00–15:40 viz studijní materiály/see study materials, Út 21. 11. 14:00–15:40 viz studijní materiály/see study materials
Předpoklady
aZLFA0621c Farmakologie I - cvičení && aZLPA0622c Patologie II - cvičení && aZLPF0622c Patol. fyziologie II -cvičení && aZLOR0641c Ortodoncie I - cvičení && aZLPD0631c Parodontologie I - cvičení
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
At the end of the course students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum.
Výstupy z učení
Students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum with the special attention paid to preparations used in dentistry.
Osnova
  • 1. Analgesics of morphine type. Pharmacotherapy of pain. Non-opioid analgesics, non-steroidal anti-inflammatory drugs. Classification, targets of effects, mechanisms of action, topically applied anti-inflammatory drugs.
  • 2. Local and general anaesthetics Overview, classification and mechanisms of action, side effects.
  • 3. H1 antihistamines, antiasthmatics Classification and clinical use of H1 antihistamines. Pathophysiology of bronchial asthma, sites and mechanisms of action of antiasthma drugs.
  • 4. Introduction to psychopharmacology. Antipsychotics, anxiolytics, hypnosedatives – mechanisms of action, side effects. Antidepressant drugs. Classification, mechanisms of action, adverse effects.
  • 5. Antihypertensives. Diuretics, antiadrenergics, vasodilators, combinative pharmacotherapy. Pharmacotherapy of ischemic heart disease.
  • 6. Antidiabetic drugs. Therapy of type 1 and 2 DM. Insulins, peroral antidiabetics. Treatment of selected GIT disorders.
  • 7. Specifities of pharmacotherapy in pediatric population, in elderly, in pregnant women and during lactation.
  • 8. Drug interactions at different levels.
Literatura
    povinná literatura
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN a H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier, 2020, xvi, 789. ISBN 9780702074486. info
    neurčeno
  • Lippincott's Illustrated Reviews : Pharmacology, 4th Ed., Harvey, Richard A. - Champe, Pamela C. - Finkel, Richard - Cubeddu, Luigi - Clarke, Michelle A. 2008. 560 s. ISBN-10: 0-7817-7155-2, ISBN-13: 978-0-7817-7155-9
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
Záložky
https://is.muni.cz/ln/tag/LF:aZLFA0722p!
Výukové metody
Presentatios of lectures will be provided in e-form as commented presentations. Students are expected to follow the provided lectures.
Metody hodnocení
The final exam will be in the oral form.
Vyučovací jazyk
Angličtina
Informace učitele
Information for students:


Students are asked to answer three randomly chosen questions dealing with the topics listed in synopses: Pharmacology I Lectures, Pharmacology I Practicals, Pharmacology II Lectures, Pharmacology II Practicals.




QUESTIONS ON GENERAL PHARMACOLOGY:



Routes of administration - overview, characteristics


Basic pharmacokinetic parameters and processes (overview)


Drug absorption, "first pass" effect


Biovailability of drugs


Drug distribution, volume of distribution


Drug elimination


Drug biotransformation, phases of biotransformation


Effect of environment pH and pKa of drugs on the drug transfer across biological membranes


Enzyme inhibition and induction


Drug excretion


Pharmacokinetics of single, repeated and continous drug administration


Pharmacokinetics of drug oral and parenteral administration


Drug dosage forms - overview and influence on pharmacokinetics


Therapeutic drug monitoring


Dose and effect, types of doses


Pharmacogenetics, pharmacogenetic polymorphism


Mechanisms of drug action - overview, non specific mechanisms of drug action


Specific mechanisms of drug action - the target structures, on which the drug act


Adverse drug reactions (types, categories)


Drug receptors theory - types of receptors


Tolerance, tachyphylaxis


Drug addiction


Therapeutic index, therapeutic range


Influence of concomitant diseases on drug effect, polypragmasia


Drug allergy (hypersensitivity), idiosyncrasy


Drug interactions- overview, pharmacokinetic interactions


Drug interactions- overview, pharmacodynamic interactions


Factors influencing the drug effect (related to drug, related to organism)


Pharmacoterapy in pregnancy, drug teratogenicity


Pharmacotherapy in breastfeeding women, in pediatric population


Pharmacoterapy in elderly


Pharmacology, sub-branches, origin of drugs, drug names


Pharmacopoeia


Rational pharmacotherapy, drug anamnesis, compliance


Development of a new drug (Drug life cycle)


Preclinical and clinical evaluation of drugs


Pharmacovigilance


General principles of drug poisoning therapy, specific antidotes and their mechanisms of action


Principles of biological therapy - technology, requirements on the quality, registration, biosimilars





QUESTIONS ON SPECIAL PHARMACOLOGY:



Antimycotics


Antivirotics


Drugs with the topic action used in stomatology - overview


Antiinfective drugs used in stomatology


Disinfectants and antiseptics


Drugs with the topic action - dermatologics, drugs used in ORL


Principles of antibiotic therapy - overview, mechanisms of action, resistance


Antibiotics for topic use


Penicillines


Cephalosporins and other beta-lactams


Aminoglycosides


Macrolides


Sulphonamides


Tetracyclines


Quinolones and nitroimidazoles


Non-steroidal antiinflammatory drugs + Analgesics - antipyretics


Drugs used in gout


General anaesthetics


Premedications and supplement general anaesthesia, analgosedation, neuroleptanalgesia


Central and peripheral myorelaxants


Ester-type local anaesthetics


Amide-type local anaesthetics


Types and techniques of local anaesthesia


Pharmacoterapy of anaphylactic shock


Antitussives, expectorants


Hypolipidemics, lipid-lowering drugs


Drugs used in heart failure


Histamine H1-blockers


Antiasthmatics


Antihypertensives - overview + ACE inhibitors, sartans, renine antagonists


Antihypertensives - overview + diuretics, alpha1-lytics


Antihypertensives - overview + beta-blockers, central antihypertensives


Antiulcer drugs


Laxatives, antidiarrhoics


Antiemetics, prokinetics


Spasmolytics, digestives


Vitamins AEDK


Hydrophilic vitamins


Psychopharmacs - overview, classification


Hypnosedatives


Antiepileptic drugs


Antipsychotics


Anxiolytics


Antidepressants


Nootropics, drugs affecting cognitive functions


Psychostimulants, hallucinogenic and delirogenic drugs


Antidysrhytmics


Cardiotonics, inotropic drugs


Alkylating cytostatics and other impacts of DNA


Antimetabolites + hormonal therapy in oncology


Glucocorticoids


Thyroid + anti-thyroid drugs


Drugs used in osteoporosis


Sex hormones - HRT, contraceptives


Uterotonics, tocolytics


Insulins


Antidiabetics for the treatment of type 2 DM


Anticoagulants, antiplatelet drugs


Antithrombotics, trombolytics


Opioid analgesics


Drugs causing addiction and pharmacological possibilities of addiction treatment


Drugs affecting ANS - neurotransmission, receptors of ANS, basic overview


Sympathomimetic agents - basic effects and classification - direct sympathomimetics


Sympathomimetic agents - basic effects and classification - indirect sympathomimetics


Sympatholytic agents - basic effects and classification - direct sympatholytics


Sympatholytic agents - basic effects and classification - indirect sympatholytics


Cholinomimetic agents - basic effects and classification - direct cholinomimetics


Cholinomimetic agents - basic effects and classification - indirect cholinomimetics


Cholinolytic agents - basic effects and classification - direct cholinolytics (parasympatholytics, ganglioplegics)




LIST OF GENERIC NAMES –„ESSENTIAL DRUGS“:


pantoprazole


famotidine


atropine


butylscopolamine


fenpiverine, pitofenone


metoclopramide


ondansetron


lactulose


insulin lispro


metformin


glibenclamide


warfarin


enoxaparin


acetylsalicylic acid


digoxin


propafenone


amiodarone


epinephrine


norepinephrine


dopamine


ephedrine, pseudoephedrine


nitroglycerin


methyldopa


clonidine


urapidil


hydrochlorothiazide


furosemide


metoprolol


labetalol


nifedipine


verapamil


enalapril


losartan


atorvastatin


ezetimibe


nystatin


ketoconazole


methylergometrine


hexoprenaline


alfuzosin


oxytocin


dexamethasone


prednisone


doxycycline, chloramphenicol


amoxicillin


phenoxymethylpenicillin


oxacillin


piperacillin, co-piperacillin


cefuroxime


cotrimoxazole


clarithromycin


gentamicin


ciprofloxacin


fluconazole


aciclovir


zidovudine


cyclophosphamide


methotrexate


6-mercaptopurine


5-fluorouracil


paclitaxel


doxorubicin


cisplatin


trastuzumab


tamoxifen


interferon alpha


ibuprofen


diclofenac


indomethacin


nimesulide


suxamethonium


allopurinol


alendronic acid


lidocaine


procaine


trimecaine


articaine


sevoflurane


thiopental


propofol


dihydrocodeine


sufentanil


piritramide


tramadol


paracetamol (acetaminophen)


metamizole


sumatriptan


valproic acid


gabapentin


haloperidol


risperidone


olanzapine


lithium


diazepam


alprazolam


zolpidem


midazolam


escitalopram


amitriptyline


bupropion


methylphenidate


donepezil


physostigmine


methadone


buprenorphine


betahistine


oxymetazoline, xylometazoline


phenylephrine


salbutamol


fenoterol


ipratropium bromide


nedocromil


acetylcysteine


bromhexine


codeine


butamirate


bisulepine


cetirizine


desloratadine


pilocarpine


timolol


tropicamide

Další komentáře
Studijní materiály
Předmět je vyučován každoročně.
Nachází se v prerekvizitách jiných předmětů

Zobrazit další předměty

Předmět je zařazen také v obdobích podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2021, podzim 2022, podzim 2024.