FaF:FAME1_16 Molecular Biology - Informace o předmětu

FAME1_16 Molecular Biology

Rozsah

2/0/0. 3 kr. Ukončení: zk.
Vyučováno kontaktně

Vyučující

Mgr. Marie Brázdová, Ph.D. (přednášející)
PharmDr. Zuzana Soldánová (přednášející)
Mgr. Daniel Renčiuk, Ph.D. (přednášející)
Mgr. Denis Šubert (přednášející)
PharmDr. Jakub Treml, Ph.D. (přednášející)

Garance

Mgr. Marie Brázdová, Ph.D.
Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta

Rozvrh

každý sudý pátek 12:00–15:20 45-224

Předpoklady

FAKULTA(FaF) || OBOR(MUSFaF)
The knowledge of subject in range of lectures.

Omezení zápisu do předmětu

Předmět je určen pouze studentům mateřských oborů.

Mateřské obory/plány

• Multidisciplinární studia na farmaceutické fakultě (program CST, KOS)
• Pharmacy (program FaF, M-FARMA)

Cíle předmětu

The aim of this subject is to provide students with basic information from molecular biology. The ground of lectures is focused on structure of proteins and nucleic acids and functions and relationships of these informational macromolecules in transition of genetic information. Students will familiarise with structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression. The molecular mechanisms of mutagenesis, recombination and transposition, reparation mechanisms and molecular basis of carcinogenesis are explained. The fundament of molecular evolution and theory of life origin on Earth are illustrated. Part of the lectures is focused on molecular biology methods and on applications of molecular biology principles in microbiology, pharmacology, human genetics, epidemiology and epizootology.

Výstupy z učení

Basic knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis;

Osnova

• 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
  2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
  3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
  4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
  5) Regulation of gene expression, molecular signalling.
  6) RNA interference
  7) Replication, expression of bacterial and animal virus's genes.
  8) Mutagenesis, spontaneous and induced mutation and reversion.
  9) Molecular basis of recombination, recombinantion in genetics.
  10) Transposons, mechanisms of transposition, retroelements, retroviruses.
  11) Reparation and excision mechanisms.
  12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
  13) Cell cycle and apoptosis
  

Literatura

doporučená literatura
• RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
• WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
• ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info

Výukové metody

lectures, videos

Metody hodnocení

Written examination test - answering questions (to successfully complete 60 %) .

Vyučovací jazyk

Angličtina

Informace učitele

- rating from written test at least 60%

Další komentáře

Předmět je dovoleno ukončit i mimo zkouškové období.

• Statistika zápisu (nejnovější)
  
• Permalink: https://is.muni.cz/predmet/pharm/podzim2024/FAME1_16