FASC1_12 Supramolecular Pharmacy

Farmaceutická fakulta
podzim 2024
Rozsah
2/0/0. 3 kr. Ukončení: zk.
Vyučující
Ing. Ondřej Jurček, Ph.D. et Ph.D. (přednášející)
Garance
Ing. Ondřej Jurček, Ph.D. et Ph.D.
Ústav přírodních léčiv – Ústavy – Farmaceutická fakulta
Dodavatelské pracoviště: Ústav přírodních léčiv – Ústavy – Farmaceutická fakulta
Rozvrh
Út 8:00–9:40 45-224
Předpoklady
Elemental knowledge of pharmacy, organic, inorganic, and analytical chemistry
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Předmět si smí zapsat nejvýše 20 stud.
Momentální stav registrace a zápisu: zapsáno: 11/20, pouze zareg.: 0/20, pouze zareg. s předností (mateřské obory): 0/20
Mateřské obory/plány
Cíle předmětu
There is an emerging interest in novel advanced drug delivery strategies and complex approaches based on knowledge obtained in supramolecular chemistry and nanoscience. The course will inform students about basic principles of supramolecular chemistry and supramolecular pharmacy and various approaches known and studied. Although the field is wide, this course sets a goal to clearly explain the basic principles and the state-of-the-art knowledge about novel advanced materials as well as to provide further opportunities for more-in-depth studies. There is an ongoing introduction of such advanced nanosized systems to clinical applications and further progress in the field is desirable and inevitable – possibly in your hands.
Výstupy z učení
The student will understand the basic principles of intermolecular interactions and importance of various chemical functional groups of neutral, anionic, or cationic molecules in solid and liquid phase. The student will be able to apply the knowledge on various drug delivery systems – making a sophisticated supramolecular match between a drug and a carrier. Elemental understanding of these complex processes will also provide the student with an ability to design and choose proper drug carrier and to estimate its effectivity in drug binding, carrying, targeting, and release, or even to optimize some parameters for its better performance.
Osnova
  • 1. Introduction to supramolecular, material chemistry, and nanoscience. Drug delivery strategies. Natural products and renewable raw materials 2. Co-crystallization and polymorphism, their description, synthesis, characterization, and applications 3. Macrocyclic compounds in drug delivery 4. Artificial anion transporters and covalent cages for pharmaceutical applications 5. Nanoparticles in drug delivery (nanocrystals, micelles, liposomes, and other) 6. Polymers and their applications 7. Gels and metallogels: components, preparation, characterization, and applications 8. Metallo-supramolecular cages: ligand design, preparation, characterization, and application 9. Porous solid materials, silicates, Metal-Organic Frameworks (MOFs), preparation, characterization, and applications 10. MOFs in medicinal applications: drug loading and delivery strategies 11. Photomedicine 12. Molecular machines
Literatura
  • Selected chapters of Supramolecular Chemistry, Jonathan W. Steed, Jerry L. Atwood, ISBN: 978-1-119-58251-9, complemented by selected research articles with pharmaceutical relevance to selected topics.
  • complemented by selected research articles with pharmaceutical relevance to selected topics
Výukové metody
Lectures
Metody hodnocení
Written possibly complemented by a colloquium.
Vyučovací jazyk
Angličtina
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích podzim 2023.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/pharm/podzim2024/FASC1_12