K1FF1_12 Principles of Phytochemistry and Pharmacognosy

Faculty of Pharmacy
Autumn 2024
Extent and Intensity
2/1/0. 5 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
PharmDr. Marie Čulenová, Ph.D. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
Mgr. Jovana Lisičić (seminar tutor)
Mgr. Juraj Markuš (seminar tutor)
prof. PharmDr. Karel Šmejkal, Ph.D. (seminar tutor)
Guaranteed by
PharmDr. Marie Čulenová, Ph.D.
Department of Natural Drugs – Departments – Faculty of Pharmacy
Timetable
Tue 8:00–9:40 44-056
  • Timetable of Seminar Groups:
K1FF1_12/01: Mon 23. 9. to Fri 13. 12. each odd Monday 13:00–14:40 45-229
K1FF1_12/02: Mon 23. 9. to Fri 13. 12. each odd Monday 15:00–16:40 45-229
K1FF1_12/03: Mon 23. 9. to Fri 13. 12. each odd Monday 17:00–18:40 45-229
Prerequisites
K1ZB1_12 Principles of Botany
Basic knowledge of botany.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course provides basic knowledge of plant constituents - types of secondary metabolites, their structures, isolation and identification, mechanism of action and practical use in therapy.
Learning outcomes
The student will gain basic information about the isolation and identification of plant substances, about the basic classes of secondary plant metabolites, their effects and use.
Syllabus
  • Introduction to pharmacognosy and phytochemistry, historical aspects and the present I and II 1) History of plant use, significance for plants, significance for humans, basic terms, classification and sorting systems of natural substances 2) Pharmacognosy, biosynthesis of natural substances, primary and secondary metabolites, primary metabolism of plants Methodology in the field of natural substances Basics of separation and isolation of natural substances (approaches, selection and preparation of plant material, choice of methods, stability of substances, classic extraction methods, separation, purification Advanced extraction methods Green" extraction methods (definition, meaning, principles), SFE, microwave-assisted extraction, ultrasound assisted extraction, enzyme-assisted extraction, high pressure assisted extraction, pulsed electric field extraction, pressurized liquid assisted extraction, high voltage electrical discharge, combined methods Chromatographic methods TLC, column chromatography, HPLC, gas chromatography Identification of natural substances Spectroscopic methods, UV/Vis, IR, MS, NMR, biological activity testing, standardization Secondary metabolites I-VIII 1) Simple sugars, polysaccharides 2) Derivatives derived from acetic acid – fatty acids, oils, fats, waxes 3) Derivatives derived from acetic acid – aromatic substances 4) Phenolic substances – aromatic acids, flavonoids, tannins 5) Terpenoids - essential oils 6) Alkaloids 7) Vegetable dyes, vitamins 8) Peptides and proteins
Literature
    recommended literature
  • Nagy M., Mučaji P., Grančai D. Farmakognózia. Biologicky aktívne rastlinné metabolity a ich zdroje. Bratislava: Herba 2015, 375 s. ISBN 978-80-89631-45-2
  • Grančai, D., Nagy, M., Mučaji, P. Farmakognózia - Biogenéza prírodných látok. 2015. ISBN 978-80-8063-368-4. info
  • Šmejkal K, Muselík J, Mokrý P. Laboratorní metody experimentální fytochemie. Brno, 2013. ISBN 978-80-7305-649-0. info
  • Šmejkal K, Muselík J, Mokrý P. Laboratorní metody experimentální fytochemie. Brno, 2013. ISBN 978-80-7305-649-0. info
  • Kubínová R., Jankovská D. Obrazový atlas farmaceuticky významných drog. Brno, 2013. ISBN 978-80-7305-667-4. info
  • BRUNETON, Jean. Pharmacognosy, phytochemistry, medicinal plants. Intercept, 1999. ISBN 978-2-7430-0316-6. info
Teaching methods
Lectures, practical classes, homework.
Assessment methods
Final written exam.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Teacher's information
100% attendance of all the practices
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2024/K1FF1_12