FaF:FAFT1_14 Pharmacology I - Course Information

FAFT1_14 Pharmacology I

Extent and Intensity

3/3/0. 7 credit(s). Type of Completion: z (credit).

Teacher(s)

MUDr. PharmDr. Marek Frydrych, Ph.D. (lecturer)
PharmDr. Bc. Kateřina Horská, Ph.D. (lecturer)
MUDr. Marta Chalupová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
doc. RNDr. Eva Račanská, CSc. (lecturer)
MUDr. PharmDr. Marek Frydrych, Ph.D. (seminar tutor)
PharmDr. Bc. Kateřina Horská, Ph.D. (seminar tutor)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
doc. RNDr. Eva Račanská, CSc. (seminar tutor)

Guaranteed by

doc. PharmDr. Peter Kollár, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Pharmacy (programme FaF, M-FARMA)

Course objectives

Pharmacology is a science that studies interactions of medical substances and organisms on various morphological and physiological levels. It focuses on mechanisms and time progress of medicines in organisms (pharmacokinetics), and on medicines impact mechanisms on an organism (pharmacodynamics). Certain toxicology sections (science on toxins) constitute a part of the pharmacology in the area of undesirable effects as well.

Syllabus

• General pharmacology
  Pharmacokinetics
  Types of drug transport (translocation) in organism
  Absorption of drugs, influencing factors
  Distribution of drugs in organism, influencing factors
  Distribution - physiological barriers
  Metabolism of drugs, influencing factors
  Mechanisms of drugs excretion, influencing factors
  Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy
  Factors influencing pharmacokinetics
  Pharmacodynamics
  Mechanisms of drugs action
  Quantitative (graded) and quantal (population) dose (concentration)- response relationships. Therapeutic index
  Drugs interactions
  Adverse and toxic effects of drugs
  Drug dependence, basic types
  Preclinical testing of drugs
  Clinical testing of drugs
  Pharmacology and human genome (pharmacogenomics, gene therapy)
  Special Pharmacology
  Pharmacology of the peripheral nervous system
  Autonomic nervous system - muscarinic agonists (parasympathomimetics). Inhibitors of cholinesterase
  Autonomic nervous system - muscarinic antagonists (parasympatholytics)
  Autonomic nervous system - adrenoceptor agonists (sympathomimetics)
  Autonomic nervous system - adrenoceptor antagonists (sympatholytics)
  Neuromuscular-blocking drugs
  Local anaesthetics
  Pharmacology of cardiovascular system
  Pharmacotherapy of chronic heart failure
  Antidysrhythmic drugs
  Pharmacotherapy of coronary heart disease: Therapy of angina pectoris. Overview of therapy of acute myocardial infarction
  Vasoactive drugs
  Inhibitors of angiotensin-converting enzyme. Antagonists of angiotensin receptors AT1
  Pharmacotherapy of arterial hypertension
  Pharmacology of the kidney
  Diuretics
  Drugs acting on haemostasis and fibrinolysis
  Drugs acting on the haemopoietic system: Treatment of anaemia by iron, folic acid and vitamin B12. Overview of haemopoietic growth factors
  Atherosclerosis and lipoprotein metabolism
  Atherosclerosis risk factors, pharmacological and non-pharmacological prevention
  Pharmacotherapy of dyslipidaemias

Literature

required literature
• Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
• Humphrey P. Rang, Maureen M. Dale, James M. Ritter and Rod J. Fl. Rang & Dale's Pharmacology, 8th Edition. 2016. ISBN 978-0702053627. info

recommended literature
• Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
• Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info

Language of instruction

English

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.

Listed among pre-requisites of other courses

• FAFT2_14 Pharmacology II
  (fakulta(FaF) || obor(MUSFaF)) && FAFT1_14  

Teacher's information

Conditions for successful completion of seminars and obtaining credits are as follows:
1. Complete all seminars (100% Attendance is necessary)
2. To score at least 65% to pass the credit test.

• Enrolment Statistics (Spring 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/spring2020/FAFT1_14