FaF:F1FG2_12 Pharmacognosy II - Course Information

F1FG2_12 Pharmacognosy II

Faculty of Pharmacy
Spring 2023

Extent and Intensity

2/5/0. 10 credit(s). Type of Completion: zk (examination).

Teacher(s)

Guaranteed by

prof. PharmDr. Karel Šmejkal, Ph.D.
Department of Natural Drugs – Departments – Faculty of Pharmacy
Contact Person: Mgr. Polina Shpet
Supplier department: Department of Natural Drugs – Departments – Faculty of Pharmacy

Timetable

Wed 8:30–10:10 44-056

Timetable of Seminar Groups:

F1FG2_12/01: Mon 7:15–11:25 45-229, I. Daňková
F1FG2_12/02: Mon 11:30–15:40 45-229, P. Herczogová, D. Jankovská
F1FG2_12/03: Mon 15:45–19:55 45-229, S. Jusková, R. Kubínová, J. Václavík
F1FG2_12/04: Tue 7:30–11:40 45-229, P. Shpet, K. Šmejkal
F1FG2_12/05: Tue 12:00–16:10 45-229, M. Gáborová, L. Molčanová

Prerequisites

F1FG1_12 Pharmacognosy I
The students should have passed basic subject touching organic chemistry, analytical chemistry, biology, botany, and physiology.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 165 student(s).
Current registration and enrolment status: enrolled: 103/165, only registered: 0/165, only registered with preference (fields directly associated with the programme): 0/165

fields of study / plans the course is directly associated with

Pharmacy (programme FaF, M-FARM)
Multidisciplinary studies at Faculty of Pharmacy (programme CST, KOS)

Course objectives

Objectives of Pharmacognosy are to impart knowledges of those drugs of biological origin and their constituents that are of value for their therapeutic, profylactic and diagnostic use in the human and veterinary medicine.
Its scope includes the study of the physical, chemical, biochemical and biological properties of drugs, drug substances, or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources. Research problems in pharmacognosy include studies in the areas of phytochemistry, microbial chemistry, biosynthesis, biotransformation, chemotaxonomy, and other biological and chemical sciences.
Pharmacognosy represents a highly interdisciplinary science which is one of five major areas of pharmaceutical education.

Learning outcomes

The student must be able to microscopically and macroscopically identify selected drugs, know their main content substances, use, basic biosynthetic reactions, basal classes of secondary metabolites. Know the main plants used in the pharmacy. Chemical characteristics of secondary metabolites, basic knowledge of structure-activity relationships, basic knowledge of adverse effects and interactions.

Syllabus

Syllabus of lectures
" Drugs affecting the central and peripheral nervous system
" Drugs affecting vegetative nervous system
" Drugs affecting the cardiovascular system
" Drugs affecting hemocoagulation, fibrinolysis and used as the substitution of blood plasma
" Drugs affecting water balance of the organism
" Drugs affecting the respiratory system
" Drugs affecting the digestive system
" Uterotonics, antiuratics, antiphlogistics
" Dietetics, roborants, geriatrics, sources of vitamins, supporting therapy of diabetes mellitus
" Hormones, enzymes
" Anti-infectious and anti-invasive drugs
" Drugs used for their local anesthetic activity
" Biogenic additives
" Natural substances inspirational for synthesis
SYLABUS OF PRACTICAL CLASSES FROM PHARMACOGNOSY II
1. Drugs containing carbohydrates
Identification assays
Purity assays
2. Drugs containing polysaccharides and mucilages
Identification assays
Determination of number of swelling
3. Drugs containing phenolics glycosides
Identification assays
Chromatographic proof of hydroquinones and arbutin
Determination of arbutin content by titration
4. Drugs containing cardioglycosides (test no. 1)
Identification assays
Chromatographic proof
Colorimetric determination
5. Drugs containing the anthracene derivatives
Identification assays
Chromatographic proof of anthraquinone derivatives
Quantification of hypericin
6. Drugs containing flavonoid glycosides
Identification assays
Colorimetric quantification of flavonoids
Chromatographic proof
7. Drugs containing saponins (test no. 2)
Identification assays
Determination of hemolytic activity using blood agar
Determination of foaming power according to Kofler
Quantification of glycyrrhizinic acid
8. Drugs containing tannins
Identification assays color, precipitation
Chromatographic proof
Quantification of tannins in drug quantification of total phenolics
9. Drugs containing essential oils
Identification assays
Chromatographic proof
Quantification of essential oils
10. Drugs containing alkaloids I. (test no. 3)
Precipitation and color reaction of alkaloids
Quantification of tropane alkaloids using titration
11. Drugs containing alkaloids II.
Precipitation and color reaction of alkaloids
Gravimetric quantification of purine alkaloids
Thin layer chromatography of opium alkaloids
12. Drugs containing bitter substances
Identification assays
Determination of number of bitterness
13. Drugs containing thioglycosides of Brassicaceae
Identification assays and purity
14. Drugs containing coumarins, anthocyanins ( test no. 4)
Chromatographic proof

Literature

required literature

Šmejkal, K., Kubínová, R., Suchý, V. Farmakognozie část obecná. 2016. ISBN 978-80-7305-785-5. info
Kubínová R., Jankovská D. Obrazový atlas farmaceuticky významných drog. Brno, 2013. ISBN 978-80-7305-667-4. info
Suchý V. a kol. Praktická cvičení z farmakognosie. Brno, 2013. ISBN 978-80-7305-659-9. info
Tomko, J. a kol. Farmakognózia. Osveta, 1999. info
Suchý, V. Farmakognosie, část všeobecná, část speciální I. UK Bratislava, 1994. info

recommended literature

Český lékopis 2017. 2017. ISBN 859-404-924-045-6. info
Nagy, M., Mučaji, P., Grančai, D. Farmakognózia. 2017. ISBN 9788089631643. info
Samuelsson G., Bohlin L. Drugs of Natural Origin. A Treatise of Pharmacognosy. 7th revised edition. 2015. info
Grančai, D., Nagy, M., Mučaji, P. Farmakognózia - Biogenéza prírodných látok. 2015. ISBN 978-80-8063-368-4. info
Suchý V. Fytofarmaka. In Kuchař M. ed. Farmaceutický encyklopedický slovník. Praha, 2014. info
Wichtl M. Herbal Drugs and Phytopharmaceuticals. 2002. info
Dewick P.M. Medicinal Natural Products. 2002. info
Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 1999. info
Bučková, A. a kol. Praktické cvičenia z farmakognózie, chemická časť. UK Bratislava, 1993. info
Mika, K. Fytoterapia. Osveta, 1988. info
Kindl, H., Vöber, B. Biochemie rostlin. Academia Praha, 1981. info

Teaching methods

Lectures Practical excersises Discussion with teachers and brainstorming

Assessment methods

Completion of practical exercises, succesfull passing the test (min. 60%, 1 regular and 2 amendatory attempts) Practical exam - knowledge of selected drugs, knowledge of ingredients and uses Oral examination (knowledge of Phytochemistry, Pharmacognosy I a II). The number of terms is final.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.

Teacher's information

100% participation in practical exercises At least 60% success in all tests (1 standard + 2 correction attempts) Before the exam, passing a practical exam related to the recognition of 10 macroscopic and 3 microscopic preparations, description of drugs, ingredients, use and common identity tests. Knowledge of Pharmacognosy within the scope of the syllabus. The number of dates listed before the exam period is terminal, you need to plan.

The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2022, Spring 2024, Spring 2025.

Enrolment Statistics (Spring 2023, recent)
Permalink: https://is.muni.cz/course/pharm/spring2023/F1FG2_12

FaF:F1FG2_12 Pharmacognosy II - Course Information

F1FG2_12 Pharmacognosy II

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