FAFG2_12 Pharmacognosy II

Farmaceutická fakulta
jaro 2023
Rozsah
2/5/0. 10 kr. Ukončení: zk.
Vyučující
prof. PharmDr. Karel Šmejkal, Ph.D. (přednášející)
prof. PharmDr. Karel Šmejkal, Ph.D. (cvičící)
PharmDr. Martin Helcman (cvičící)
Mgr. Polina Shpet (pomocník)
Garance
prof. PharmDr. Karel Šmejkal, Ph.D.
Ústav přírodních léčiv – Ústavy – Farmaceutická fakulta
Rozvrh
Út 14:45–16:25 45-221
  • Rozvrh seminárních/paralelních skupin:
FAFG2_12/01: St 7:30–11:40 45-229, M. Helcman, P. Shpet
Předpoklady
Knowledge of organic chemistry, analytical chemistry, phytochemistry, biochemistry, physiology.
This knowledge will be strictly demanded.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 24 stud.
Momentální stav registrace a zápisu: zapsáno: 6/24, pouze zareg.: 0/24
Mateřské obory/plány
Cíle předmětu
Pharmacognosy deals with the sources of natural drugs and the products of plant metabolism, used and useful for treatment, prophylaxis, and diagnosis in human and veterinary medicine.
Výstupy z učení
The student must be able to microscopically and macroscopically identify selected drugs, know their main content substances, use, basic biosynthetic reactions, basal classes of secondary metabolites. Know the main plants used in the pharmacy. Chemical characteristics of secondary metabolites, basic knowledge of structure-activity relationships, basic knowledge of adverse effects and interactions.
Osnova
  • Syllabus of lectures
    " Drugs affecting the central and peripheral nervous system
    " Drugs affecting vegetative nervous system
    " Drugs affecting the cardiovascular system
    " Drugs affecting hemocoagulation, fibrinolysis and used as the substitution of blood plasma
    " Drugs affecting water balance of the organism
    " Drugs affecting the respiratory system
    " Drugs affecting the digestive system
    " Uterotonics, antiuratics, antiphlogistics
    " Dietetics, roborants, geriatrics, sources of vitamins, pomocní léčba od diabetes mellitus
    " Hormones, enzymes
    " Anti-infectious and anti-invasive drugs
    " Drugs used for their local activity
    " Biogenic additives
    " Natural substances inspirational for synthesis
    Laboratory practice summer half
    1. Drugs containing saccharides
    Identification
    Tests of purity
    2. Drugs containing polysaccharides and mucilages
    Identification
    Determination of swelling number
    3. Drugs containing phenolic glycosides
    Identification
    Chromatographic proof of arbutin and hydroquinone
    Titrating determination of arbutin
    4. Drugs containing cardioglycosides (Control test I)
    Identification
    Chromatographic proof
    Colorimetric determination
    5. Drugs containing antraquinone glycosides
    Identification
    Chromatographic proof
    Colorimetric determination of hypericin
    6. Drugs containing flavonoid glycosides
    Identification
    Colorimetric determination of flavonoids
    Chromatographic proof
    7. Drugs containing saponins (Control test II)
    Identification
    Determination of hemolytic activity on blood agar
    Determination of number of foamability according to Kofler
    Determination of glycyrrhizinic acid
    8. Drugs containing tannins
    Identification - color and precipitation reactions
    Chromatographic proof
    Colorimetric determination
    9. Drugs containing volatiles
    Identification
    Chromatographic proof
    Hydro distillation determination
    10. Drugs containing alkaloids I. (Control test III)
    Identification ? color and precipitation reactions
    Titration determination of tropane alkaloids
    11. Drugs containing alkaloids II.
    Identification - color and precipitation reactions
    Gravimetric determination of purine alkaloids
    Thin layer chromatography of poppy opium alkaloids
    12. Drugs containing bitter substances
    Identification
    Determination of number of bitterness
    13. Drugs containing mustard glycosides
    Identification and purity
    14. Drugs containing coumarins, anthocyanins (Control test IV)
    Chromatographic proof
Literatura
    povinná literatura
  • Dewick P. Medicinal natural products, a biosynthetic approach. Hoboken, 2008. ISBN 9780470741689. info
  • Bruneton Jean. Pharmacognosy, Phytochemistry, Medicinal Plants. 1999. ISBN 1898298637. info
    doporučená literatura
  • Samuelsson G., Bohlin L. Drugs of Natural Origin. A Treatise of Pharmacognosy. 7th revised edition. 2015. info
  • Evans W Ch. Trease and Evans' Pharmacognosy. 2009. ISBN 9780702029332. info
  • Wichtl M. Herbal Drugs and Phytopharmaceuticals. 2002. info
Výukové metody
Dialogic (discussion, interview, brainstorming)
Methods of written actions (e.g., for comprehensive exams, final exams)
Demonstration
Exercise and work skills training
Laboratory work
Metody hodnocení
Practical examination - recognition of selected drugs, knowledge of content compounds, and their utilization Oral examination
Vyučovací jazyk
Angličtina
Informace učitele
Required for crediting:
100% attendance of all the practices
Passing the written tests (60% is required to pass)
Required for examination:
Basic knowledge of plant secondary metabolism, structures of pharmaceutically, pharmacologically, or toxicologically important compounds, drugs and plant names, pharmacological or technological effects, and usage, basic methods for identification and quantification.
General examination combining Pharmacognosy I and Pharmacognosy II
Apart of pharmacognosy examination is macroscopic recognition of 10 drugs and microscopic identification of three preparates.
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2024, jaro 2025.