FAME1_16 Molecular Biology

Farmaceutická fakulta
podzim 2023
Rozsah
2/0/0. 3 kr. Ukončení: zk.
Vyučující
Mgr. Marie Brázdová, Ph.D. (přednášející)
PharmDr. Zuzana Soldánová (přednášející)
Mgr. Daniel Renčiuk, Ph.D. (přednášející)
Ing. Branislav Ruttkay-Nedecký, Dr. (přednášející)
Mgr. Denis Šubert (přednášející)
PharmDr. Jakub Treml, Ph.D. (přednášející)
Garance
Mgr. Marie Brázdová, Ph.D.
Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta
Rozvrh
každý lichý pátek 12:00–15:20 45-224
Předpoklady
FAKULTA(FaF) || OBOR(MUSFaF)
The knowledge of subject in range of lectures.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of this subject is to provide students with basic information from molecular biology. The ground of lectures is focused on structure of proteins and nucleic acids and functions and relationships of these informational macromolecules in transition of genetic information. Students will familiarise with structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression. The molecular mechanisms of mutagenesis, recombination and transposition, reparation mechanisms and molecular basis of carcinogenesis are explained. The fundament of molecular evolution and theory of life origin on Earth are illustrated. Part of the lectures is focused on molecular biology methods and on applications of molecular biology principles in microbiology, pharmacology, human genetics, epidemiology and epizootology.
Výstupy z učení
Basic knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis;
Osnova
  • 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
    2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
    3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
    4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
    5) Regulation of gene expression, molecular signalling.
    6) RNA interference
    7) Replication, expression of bacterial and animal virus's genes.
    8) Mutagenesis, spontaneous and induced mutation and reversion.
    9) Molecular basis of recombination, recombinantion in genetics.
    10) Transposons, mechanisms of transposition, retroelements, retroviruses.
    11) Reparation and excision mechanisms.
    12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
    13) Cell cycle and apoptosis
Literatura
    doporučená literatura
  • RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
  • WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
  • ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info
Výukové metody
lectures, videos
Metody hodnocení
Written examination test - answering questions (to successfully complete 60 %) .
Vyučovací jazyk
Angličtina
Informace učitele
- rating from written test at least 60%
Další komentáře
Studijní materiály
Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích podzim 2020, podzim 2021, podzim 2022, podzim 2024.