Course Information

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
In-person direct teaching

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Wed 14:00–15:50 B11/335

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students can be asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Wed 14:00–15:50 B11/335

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students can be asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 14:00–15:50 B11/335

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Thu 14:00–15:50 B11/335

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 14:00–15:50 prace doma

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. Mgr. Vítězslav Bryja, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Vondráček, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 8:00–9:50 B11/305

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 11 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELLULAR METABOLISM – cellular metabolism adaptations, metabolism of proliferating and tumor cells, signaling pathways controlling cellular metabolism; 3) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, embryonic stem cells – definition, preparation, use; induced pluripotent stem cells, tissue-specific stem cells, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; slow and fast renewing cell populations, organoids, tissue regeneration; 4) MODEL CELL SYSTEMS I – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 5) CELL SYSTEMS REGULATIONS I – main signaling pathways in homeostasis and regeneration (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); model examples of regulated processes; 6) CELL SYSTEMS REGULATIONS I - control of tissue organization by external stimuli – hypoxia, damage, mechanical forces (Hippo signaling); cell polarity and cell migration; 7) MODEL CELL SYSTEMS II – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 8) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi1120 Physiology and pathophysiology of tissue and organs
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 17. 9. to Fri 14. 12. Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELL SYSTEMS DURING EMBRYOGENESIS I – basic principles of embryonic development, main morphogenetic signaling pathways (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); 3) CELL SYSTEMS DURING EMBRYOGENESIS II – main morphogenetic signaling pathways – continuation (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling), limb development as a model example; 4) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; 5) MODEL CELL SYSTEMS I – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 6) MODEL CELL SYSTEMS II – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 7) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 8) CELLULAR METABOLISM AND TRANSPORT - hepatocyte as a model system for metabolism of lipids and fatty acids; synthesis, accumulation and storage of saccharides; metabolism of nitrogen-containing compounds; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical dynamic system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
prof. Mgr. Vítězslav Bryja, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 18. 9. to Fri 15. 12. Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary. Closely follows the course Physiology of animal cell (Bi1110).

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

The aim of this course is to acquaint students with basic principles of animal cell behavior and functions within the context of cell populations of specific tissues and whole organism, introduce the concept of organisms as a dynamic hierarchical system and to explain to students basic principles governing cell behavior both during embryonic development and in adult organism.

Learning outcomes

At the end of the course students should be able to: describe basic principles of embryonic development and main morphogenetic signaling pathways, including description of model examples; describe the role of stem cells in maintenance of homeostasis of adult tissues; describe, using suitable models, main principles of tissue regeneration and cell differentiation (model systems including intestine, the liver, hematopoietic tissues, skin, endocrine-regulated tissues, lungs); describe principles of adaptation of cell metabolism in differentiated tissue, proliferating cells and under pathological conditions; define and apply the terms homeostasis, systemic reaction and feedback reactions in regulation of cell populations, and to apply these terms in description of behavior of cell systems during stress and disease.

Syllabus

• 1) INTRODUCTION – basic principles of organization and function of animal cells (overview of basic facts for the course); 2) CELL SYSTEMS DURING EMBRYOGENESIS I – basic principles of embryonic development, main morphogenetic signaling pathways (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling); 3) CELL SYSTEMS DURING EMBRYOGENESIS II – main morphogenetic signaling pathways – continuation (Wnt, Hedgehog, Notch, receptor tyrosine kinases, BMP/TGF signaling), limb development as a model example; 4) STEM CELLS AND HIERARCHICAL ORGANIZATION OF TISSUES – stem cell definition, stem cell niche, hierarchical organization of tissues – intestinal epithelium as a model example, intestinal crypt homeostasis; 5) MODEL CELL SYSTEMS I – development, architecture and regeneration of the liver; the liver as a model system regenerating from differentiated cells; liver zonation and molecular mechanisms of regulation of basic liver functions (bile production, detoxification and production of important compounds); 6) MODEL CELL SYSTEMS II – hematopoiesis, blood cells and hematopoietic organs; principles of cell differentiation; 7) MODEL CELL SYSTEMS III – skin, its renewal and regeneration; prostate and breast epithelium as examples of endocrine-regulated tissues; 8) CELLULAR METABOLISM AND TRANSPORT - hepatocyte as a model system for metabolism of lipids and fatty acids; synthesis, accumulation and storage of saccharides; metabolism of nitrogen-containing compounds; 9) MODEL CELL SYSTEMS IV – lungs and respiratory system – principles of development and organization; gas transport through cells and organs; 10) SIGNALING AND FEEDBACK – general principles and their application in physiology; 11) HOMEOSTASIS, HEALTH AND DISEASE – organism as a hierarchical dynamic system, combined action of neuronal and endocrine systems – examples of modulations of cell populations, intermediary metabolism and its components – their role in regulation of cell populations; systemic reactions – stress; behavior of cell systems in stress and disease – examples of therapeutic interventions;

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce, Alexander JOHNSON, Julian LEWIS, David Owen MORGAN, Martin C. RAFF, Keith ROBERTS and Peter WALTER. Molecular biology of the cell. Edited by John H. Wilson - Tim Hunt. Sixth edition. New York, NY: Garland Science, 2014, xxxiv, 134. ISBN 9780815344322. info
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. The course is finished by written exam evaluated by all teachers. Questions cover all teaching topics. Students must answer approximatelly 20 questions. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Mon 19. 9. to Sun 18. 12. Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic system Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. During lectures students are asked about subjects of past lectures. The course is finished by written exam evaluated by the teacher. Questions go through all teaching topics. Students must answer about 20 questions which go through all topics discoursed. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic system Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. During lectures students are asked about subjects of past lectures. The course is finished by written exam evaluated by the teacher. Questions go through all teaching topics. Students must answer about 20 questions which go through all topics discoursed. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic system Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. During lectures students are asked about subjects of past lectures. The course is finished by written exam evaluated by the teacher. Questions go through all teaching topics. Students must answer about 20 questions which go through all topics discoursed. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic system Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

required literature
• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info

recommended literature
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• Doporučené speciální separáty a elektronické prezentace přednášek. (Recommended thematic research papers and electronic presentation of the lectures)

Teaching methods

Lectures and class discussion. Students are asked questions dealing with subject of the past lectures.

Assessment methods

Attendance of the lectures is not mandatory but highly recommended for right understanding of educated topics. During lectures students are asked about subjects of past lectures. The course is finished by written exam evaluated by the teacher. Questions go through all teaching topics. Students must answer about 20 questions which go through all topics discoursed. 60% of correct answers is needed to pass.

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 7 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Tue 12:00–13:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 10 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Assessment methods

Lectures
final written exam

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Tue 13:00–14:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Timetable

Tue 13:00–14:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, N-BI)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Physiology of Animals)

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Timetable

Tue 13:00–14:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, N-BI)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Physiology of Animals)

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)

Guaranteed by

prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, N-BI)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Physiology of Animals)

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jakub Hofman, Ph.D. (assistant)

Guaranteed by

prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, N-BI)
• General Biology (programme PřF, M-BI, specialization Physiology of Animals)
• General Biology (programme PřF, N-BI, specialization Physiology of Animals)

Language of instruction

Czech

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

The information about the term Autumn 2011 - acreditation is not made public

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

At the end of the course students should be able to: understand cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules; use acquired knowledge of the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level; explain the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, and carcinogenesis; orientate in mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Teaching methods

Lectures and class discussion

Assessment methods

final written exam

Language of instruction

Czech

Follow-Up Courses

• Bi6871 Health Risks
• Bi8110 Mechanisms of carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• Molecular cell biology. Edited by James Darnell - Harvey Lodish - D. Baltimore. 2nd ed. New York: Scientific American Books, 1990, x, 1105 s. ISBN 0-7167-2078-7. info
• J. Neuwirt, E. Nečas: Kmenové buňky a krevní choroby, Avicenum Praha 1981
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• + doporučené speciální separáty a schemata z přednášek

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

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