C7185 Neurobiology

Faculty of Science
Autumn 2024
Extent and Intensity
2/0/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
In-person direct teaching
Teacher(s)
prof. RNDr. Omar Šerý, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Omar Šerý, Ph.D.
Department of Biochemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Biochemistry – Chemistry Section – Faculty of Science
Timetable
Tue 14:00–15:50 B11/335
Prerequisites
basics of biology and physiology - eg subject Structure and function of the cell
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 16 fields of study the course is directly associated with, display
Course objectives
Objective of the Neurobiology is to acquaint students with the basics of neurobiology, nervous cell, nervous system development, basics of neurotransmission, basics of CNS anatomy, functional neuroanatomy, principles of memory storage and methods used in neuroscience. The lectures are focused on human brain.
Learning outcomes
After completing Neurobiology, the student will be able to: describe the nerve and glial cells to describe the basic structure of the CNS to describe the development of the end-brain describe the principles of short and long term memory storage to describe the basic principles of the function of all basic neurotransmitters to explain the methods of studying the nervous system to describe the history of neuroscience development describe sensory organs and their functions
Syllabus
  • 1. Nervous system cells Neuron, axon, dendrites, neuron cytoskeleton, axonal transport, glial cells, astrocytes, microglia, oligodendrocytes 2. Development of the nervous system I Germinal development, endoderm, mesoderm, ectoderm, notochord, Hans Spemann and Hilde Mangold, BMP, neural tube differentiation, rostro-ocular differentiation, zona limitans intrathalamica, isthmic organizer, Otx2 and Gbx2, anterior differentiation, homeobox genes, Shh pathway mutations, motor differentiation neurons, Hox proteins, end-brain development, barrels (barrels) 3. Development of the nervous system II Types of neural progenitor cells division, radial glial cells, Delta - Notch, formation of cerebral cortex layers, neuronal migration patterns, neuronal survival, neurotrophic factors, stereotropic resonance, Paul Weiss, Roger Sperry, Santiago Raman Y Cajal, growth cone 4. Synaptic transmissions Chemical and electrical synapses, ionotropic and metabotropic receptors, Edwin Furshpan and David Potter, gap junctions, connexin 32, connexin 36, synaptic transmission on chemical synapses Charcot - Marie - Tooth 5. Neurotransmitters and their receptors I Types of receptors, G protein-coupled receptors, ion channels, receptors associated with enzyme function, receptors affecting gene expression, second messenger, receptor kinetics 5. Neurotransmitters and their receptors II Cholinergic neurotransmission, amino-acidergic neurotransmission, monoaminergic neurotransmission 6. Neurotransmitters and their receptors III Purinergic neurotransmission, peptidergic neurotransmission, psychopharmacology and psycho-drugs, psycho-drugs effects 7. Anatomy of the CNS Central and peripheral nervous system, sympathetic, parasympathetic, brain, brain, brain, cerebral cortex, thalamus, hypothalamus, back brain, bridge, cerebellum, spinal cord, spinal cord, limbic system, basal ganglia Functional neuroanatomy Functional asymmetry of brain hemispheres, Wernicke center, Broca center, Brodmann, Penfield, Ojeman, Posner, motivation algorithms, Papez circuit, emotions 9. Memory Memory types, Penfield experiments, Brenda Milner, hippocampus, amygdala, experiments on the genus Aplysia, Kandel and Nobel prize for physiology, molecular memory storage principles, cytosine methylation and histone modification 10. sensory organs and their functions - smell, taste, eye, balance system, hearing 11. History and Present of Neuroscience Histology, physiology, Phrenology, functional neuroanatomy, pharmacology, genetics and molecular biology, molecular psychiatry, psychology
Literature
    recommended literature
  • Carpenter's Human Neuroanatomy
  • VANDERAH, Todd W. and Douglas J. GOULD. Nolte's The Human Brain : an Introduction to its Functional Anatomy. 7th edition. Philadelphia: Elsevier, 2016, 1 online. ISBN 9781455728602. URL info
  • FIŠAR, Zdeněk. Vybrané kapitoly z biologické psychiatrie. Edited by Roman Jirák. Vyd. 1. Praha: Grada, 2001, 315 s. ISBN 8024700611. info
  • Principles of neural science. Edited by Eric R. Kandel - James H. Schwartz - Thomas M. Jessell. 3rd ed. East Norwalk: Appleton and Lange, 1991, xliv, 1135. ISBN 0-8385-8034-3. info
Teaching methods
Lectures with PowerPoint presentations, class discussion and recommended books for self study.
Assessment methods
Advanced course, oral exam
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023.
  • Enrolment Statistics (recent)
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