PřF:C9909 Fine process chemistry - Course Information
C9909 Elements of fine process chemistry
Faculty of ScienceSpring 2025
- Extent and Intensity
- 2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
In-person direct teaching - Teacher(s)
- RNDr. Petr Beňovský, Ph.D. (lecturer)
- Guaranteed by
- doc. RNDr. Ctibor Mazal, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science - Prerequisites
- Basic knowledge of organic chemistry, organic synthesis, physical chemistry
- Course Enrolment Limitations
- The course is offered to students of any study field.
- Course objectives
- This lecture should provide much broader information about practical aspects of process chemistry that is very important in the real professional life in process chemistry companies.
- Learning outcomes
- After successful completion of the lecture (passing the exam) a student should be able to understand factors that apply on different scales of a chemical process. A student should be able to independently decide which reaction system is suitable for a purpose, should be able to distinguish among several options and select the best one. A student is trained to apply theoretical knowledge and understand its impact to the outcome of the chemical reaction.
- Syllabus
- Outline of the class; History of fine process chemistry, recent trends, future; Differences between laboratory and larger scale experiments; Scale-up/downscale considerations; Safety; Crystallization (solubility, metastable zone, nucleation, crystal growth, optical resolution, Viedma ripening, attrition enhanced deracemization, seeding, Ostwald ripening, new trends in crystallization); Polymorphism; Typical process operations (mixing, heat transfer, agglomeration, product isolation, distillation, drying, purification, work up, reactors); Continuous manufacturing, flow chemistry; Synthetic route selection; Analytical methods, Process Analytical Technology (PAT), Design of Experiments (DoE), Quality by Design (QbD); Environmental Aspects; Economy, Cost of Goods (CoG); Regulatory issues, patents. Copious example from recent literature about various topics within the whole lecture.
- Literature
- Neal Anderson, Practical Process Research & Development, Elsevier, 2nd Ed. 2012
- Teaching methods
- Lectures
- Assessment methods
- Final written test
- Language of instruction
- English
- Further Comments
- The course is taught once in two years.
- Enrolment Statistics (Spring 2025, recent)
- Permalink: https://is.muni.cz/course/sci/spring2025/C9909