F8390 Metalloproteins: structure and function

Faculty of Science
Spring 2009
Extent and Intensity
1/0. 1 credit(s) (plus extra credits for completion). Type of Completion: k (colloquium).
Teacher(s)
prof. Dr. Jiří Kozelka, PhD. (lecturer)
Guaranteed by
prof. RNDr. Josef Humlíček, CSc.
Department of Condensed Matter Physics – Physics Section – Faculty of Science
Contact Person: prof. Dr. Jiří Kozelka, PhD.
Timetable
Mon 14:00–14:50 F3,03015
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
  • Biophysics (programme PřF, M-FY)
  • Biophysics (programme PřF, N-FY, specialization Molekulární biofyzika)
Course objectives
Main objectives:
- To get an overall impression of the occurrence of transition metal complexes inside of metalloproteins
- To see how inorganic chemists model the active sites of metalloproteins
- To get trained in using diverse spectroscopic methods in the study of metal active sites of metalloproteins
- To encounter examples of how nature uses the same active site for different purposes
- To learn the mechanisms of the principal oxygen carriers the nature developed
Syllabus
  • 1. Introduction
  • 1.1. Metal ions: Functions in Biological Chemistry
  • 1.2. Some fundamental metal sites in metalloproteins
  • 2. Metalloproteins reacting with oxygen
  • 2.1. General considerations
  • 2.2. Oxygen transport proteins & Oxygenases
  • 2.2.1. Hemoglobin, Myoglobin & Cytochrome P450
  • Insert: Introduction to inorganic spectroscopy
  • Insert: Important ligands in metalloproteins
  • 2.2.2. Hemocyanin & Tyrosinase
  • 2.2.3. Hemerythrin & Ribonucleotide reductase & Methane monooxygenase diiron subunits
  • 3. Examples of other active sites in metalloproteins
Literature
  • LIPPARD, Stephen J. and Jeremy M. BERG. Principles of bioinorganic chemistry. Mill Valley: University Science Books, 1994, 411 s. ISBN 0-935702-73-3. info
Assessment methods
1 Mid-term written test (not obligatory but highly recommended since it will give an impression of final test)
1 Final written test
A satisfactory accomplishment of the test will be required for the 2 credits given for this course.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Teacher's information
http://physics.muni.cz/biophys/vyuka.shtml
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2009, recent)
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