IC030 Light as a Traceless Reagent

Přírodovědecká fakulta
jaro 2009
Rozsah
0/0. 1 kr. Ukončení: z.
Vyučující
Prof. Richard S. Givens (přednášející), prof. RNDr. Petr Klán, Ph.D. (zástupce)
Garance
prof. RNDr. Petr Klán, Ph.D.
Ústav chemie – Chemická sekce – Přírodovědecká fakulta
Omezení zápisu do předmětu
Předmět je otevřen studentům libovolného oboru.
Cíle předmětu
A short course on organic photochemistry will be presented which will emphasize fundamental design and application of important light induced release of substrates employed in biology and synthesis. Six hour and a half lecture will be given on the photochemistry of processes that have proven useful in chemistry and biology in the field of “photoremovable protecting groups” (also known as “caged compounds”). Each lecture will introduce the fundamental photochemical transformation, a discussion of the mechanistic studies, the range and limitations of the system, and a series of successful applications of the photochemistry to biology and organic synthesis. Approaches to solving problems of design, mechanistic investigation, and selecting appropriate applications of light initiated reactions will be addressed when appropriate. The principal theme of the lectures will be to introduce sufficient background to understand the nature of the photochemistry, to provide insight into the design and development of candidates for caging groups, and to inspire the attendees to design and develop new chromophores and/or new applications for photoremovable protecting groups. This is intended to be an interdisciplinary approach with the goal of bringing insight toward solving difficult problems in biology and chemistry. Basic principles of photochemistry and physical organic chemistry will be introduced as needed for each topic.
Osnova
  • Lecture 1 An introduction to organic photochemistry. An elementary comparison of ground state chemical transformations with excited state reactions; driving forces, electronic states, kinetic and thermodynamic considerations. Rearrangements in ground and excited states and introduction of the Zimmerman paradigm for photochemical mechanisms. Lectures 2 and 3 Photochemistry of the o-nitrobenzyl chromophore. The general photochemistry, advantages and disadvantages, applications in biology and chemical synthesis. Lecture 4 Coumaryl derivatives and related heteroaromatic chromophores as photoremovable protecting groups as chromophores. The history, general photochemistry, mechanism, advantages and limitations for applications in biology Lecture 5 Aryl ketones as caging groups. The general photochemistry of aryl ketones, mechanistic studies, and the advantages and limitations of aryl ketones for applications in synthesis and biology. Lecture 6 Photochemical rearrangements as a paradigm for photoremovable protecting groups. Advantages, limitations, and applications in chemistry and biology.
Metody hodnocení
Účast na kurzu.
Vyučovací jazyk
Angličtina
Informace učitele
http://www.chem.ku.edu/givens/index.shtml
Kurz se uskuteční v posluchárně ústavu RECETOX (bývalé Medipo): 4. patro; Kamenice 3, 625 00 Brno, kampus Bohunice Termíny: od pondělí 4.5. do středy 6.5. 2009 (každý den 9:00–12:00) Vyučující: Prof. Richard S. Givens Department of Chemistry. The University of Kansas, Lawrence, USA e-mail: givensr@ku.edu URL: http://www.chem.ku.edu/givens/index.shtml
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Poznámka k četnosti výuky: 4.5. - 6.5.2009 9:00 - 12:00.
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  • Permalink: https://is.muni.cz/predmet/sci/jaro2009/IC030