Bi8940 Developmental biology

Faculty of Science
Spring 2011
Extent and Intensity
2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jan Hejátko, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Jiří Fajkus, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Jan Hejátko, Ph.D.
Timetable
Fri 10:00–11:50 B11/205
Prerequisites
( Bi4010 Essential molecular biology || Bi4020 Molecular biology ) && Bi1060 Plant cytology and anatomy
Advantage is the knowledge of the topics of the basic lectures from molecular biology and genetics.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course, the student should understand the basic principles of development of selected model organisms, animals and plants. During the course, there will be explained the fundamental developmental processes that allow formation of highly differentiated organism from the single-celled zygote. The fundamental developmental processes will be described at the tissue and organ levels and in the case of selected examples the molecular mechanisms driving those processes will be demonstrated. Particularly there will be described molecular mechanisms of asymmetric cell division including molecular mechanisms of asymmetric distribution of RNA, proteins and signalling molecules at the level of both the egg and zygote, formation of molecular gradients during basic body axes formation, the role of important signalling pathways in those processes, cell interactions and regulation of gene expression including recent knowledge in the field of RNA interference. The aforementioned developmental processes will be described for the most important animal and plant model organisms (amphibians, Drosophila melanogaster, mouse, human, Arabidopsis thaliana).
Syllabus
  • 1. Lesson: Overview of development, repetitorium of basic terms, gametogenesis, fertilization and lineage tracing.
  • 2. Lesson: Oogenesis and early development of Drosophila.
  • 3. Lesson: Early development of amphibians and amniotes.
  • 4. Lesson: Vertebrate organogenesis, development of ectodermal structures.
  • 5. Lesson: Vertebrate organogenesis, development of mesodermal and endodermal structures.
  • 6. Lesson: Plant reproduction, changing of generations, initiation of flowering, flower development, gametogenesis, fertilization.
  • 7. Lesson: Embryogenesis of seed plants
  • 8. Lesson: Postembryonic de novo organogenesis in plants, concept of meristems. Shoot development, SAM, phyllotaxis. Root development, RAM, lateral root formation. Shoot and root vascular tissue development. Hormonal interactions in the de novo organogenesis in plants.
  • 9. Lesson: Morphogenesis in animals, cellular associations, environment and behaviors, tissue interactions and morphogenesis. Morphogenesis in plants, leaf development, role of auxin distribution and its interaction with CK in the morphogenesis in plants
  • 10. Lesson: Regulation of gene expression. The levels of regulation of gene expression in development of animals and plants, RNA interference.
Literature
  • WILT, Fred H. and Sarah HAKE. Principles of developmental biology. New York, N.Y.: W.W. Norton & Company, 2004, xxiii, 430. ISBN 0393974308. info
Teaching methods
Lectures and presenations of image materials including video clips and supplemented by internet learning resources and original publications.
Assessment methods
Final written test.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2010, Spring 2012, spring 2012 - acreditation.
  • Enrolment Statistics (Spring 2011, recent)
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