C4460 Organic Chemistry - laboratory course

Faculty of Science
Spring 2011
Extent and Intensity
0/0/5. 5 credit(s). Type of Completion: graded credit.
Teacher(s)
RNDr. Slávka Janků, Ph.D. (seminar tutor)
Světlana Filípková (assistant)
Mgr. Zdeněk Moravec, Ph.D. (assistant)
Guaranteed by
RNDr. Slávka Janků, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Fri 9:00–13:50 C10/109
Prerequisites
C2021 Organic Chemistry I
C1080. You have to pass tests of your knowledge. Information to the practical training is at http://koch.chemi.cz/
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main aim of the practical course is to teach fundamental laboratory methods of organic chemistry in synthesis (heating, stirring, cooling, introduction of gases, working at lower pressure, drying) and separation of organic compounds (filtering, crystallization, distillation, extraction). These methods are exercised on important types of organic compounds syntheses. The products are characterized by melting point, thin-layer chromathography, refractive index, and IR-spectroscopy.
Syllabus
  • 1. a) Ethyl bromide (SN2 mechanism, distillation) b) tert-Butyl chloride (SN1 mechanism, distillation) 2. Nucleophilic substitution on aromatic system (Aminolysis of 1-chloro-2,4-dinitrobenzene) (crystallization) 3. Ethyl-acetate (esterifikation, distillation) 4. Ethyl 3-oxobutanoate ethylenacetale(nucleophilic addition mechanism to C=O, azeotropic and vacuum distillation, work with rotary evaporator) 5. 3-Nitroacetophenone (SEAr mechanism , recrystallization, IR spectroscopy) 6. 1-(3-Nitrophenyl)ethanol (selective reduction, extraction, recrystallization, IR spectroscopy) 3-Aminoacetophenone (selective reduction, recrystallization, IR spectroscopy) 7. 2-Hydroxy-5-methyl-2'-nitroazobenzene (diazotization and diazonium coupling, recrystallization, TLC) 8. Phenole nitration(SEAr mechanism, steam distillation, crystallization) 9. Anthranilic acid (Hofmann amide rearrangement, recrystallization) 10. Extraction of plant dyes on Soxhlet extractor (TLC, work with rotary evaporator) 2-Chlorobenzoic acide (diazotization and Sandmayer reaction, crystallization) 11. Pinacol (metal reduction in anhydrous non-polar solvents, work with rotary evaporator) 12. Benzoic acid(nucleophilic addition to C=O, work with anhydrous solvents, extraction, sublimation) 13. Acetylsalicylic acid (application of acetanhydride for ester preparation, crystallization) Azobenzene (electrochemical reduction, crystallization, TLC)
Literature
  • NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
Teaching methods
laboratory exercises
Assessment methods
Every exercise is started by testing knowledge and preparation for the certain synthetic method by computer. After passing the practical exercise in the laboratory a protocol of the synthesis has to be submitted.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Vyučují učitelé katedry organické chemie.
Teacher's information
http://koch.chemi.muni.cz/laboratore/index.html
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010.
  • Enrolment Statistics (recent)
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