Bi4010 Essential molecular biology

Faculty of Science
spring 2018
Extent and Intensity
2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jan Šmarda, CSc. (lecturer)
Guaranteed by
prof. RNDr. Jan Šmarda, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jan Šmarda, CSc.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Wed 11:00–12:50 B11/306
Prerequisites
! Bi4020 Molecular biology && NOW( Bi4010c Essential molecular biology )
Basic knowledge of general zoology and botany, microbiology, genetics, physiology, organic chemistry and biochemistry.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
This lecture is conceived as an introduction into molecular biology and it provides explanation of basic cell processes on molecular level. Structure of genome, principles of gene expression, internal cell organization and its behaviour in the context of multicellular organisms are the main topics of the lecture. At the end of the course, the student will be able understand and discuss molecular principles driving cellular behaviour on basic level.
Learning outcomes
At the end of the course, the student will be able understand and discuss molecular principles driving cellular behaviour on basic level.
Syllabus
  • 1. Genesis of molecular biology, milestones, main model systems. 2. Structure and function of DNA, chromosomal DNA and its packaging in the chromatin fiber, the global structure of chromosomes, how genomes evolve. 3. DNA replication and repair. 4. DNA recombination, and transposition. 5. Mechanisms of transcription, splicing and translation. 6. RNA world and the origin of life. 7. Control of gene expression, regulatory proteins, genetic switches, principles of cell differentiation, post-transcriptional controls, RNA interference. 8. Internal organization of a cell, intracellular compartments, transport of molecules between cell compartments, intracellular vesicular traffic. 9. Mechanisms of cell communication, principles of cell signalling. 10. Cell cycle, principles of control of cell cycle phases, cell division and growth. 11. Programmed cell death. 12. Molecular basis of cancer. 13. Methods available for analyses of nucleic acids and proteins (study of genomes, transcriptomes and proteomes, DNA manipulation, PCR, sequencing, transport of DNA to cells, flow cytometry).
Literature
    required literature
  • SNUSTAD, D. Peter and Michael J. SIMMONS. Genetika. Translated by Jiřina Relichová. Druhé, aktualizované vydá. Brno: Masarykova univerzita, 2017, xix, 844. ISBN 9788021086135. info
    recommended literature
  • ALBERTS, Bruce. Essential cell biology. 2nd ed. New York: Garland Science, 2004, xxi, 740. ISBN 0815334818. info
  • ROSYPAL, Stanislav, Jiří DOŠKAŘ, Roman PANTŮČEK, Jana KAILEROVÁ, Jiřina RELICHOVÁ, Vladislava RŮŽIČKOVÁ, Jan ŠMARDA, Jan ŠMARDA and Jiří ŠTĚPÁN. TERMINOLOGIE MOLEKULÁRNÍ BIOLOGIE. České odborné termíny, definice a anglické ekvivalenty (Terminology of molecular biology). První vydání. Brno: Vydavatel Prof. RNDr. Stanislav Rosypal, DrSc. Vodova 80, 612 00 Brno, 2001, 300 pp. ISBN 80-902562-3-6. URL info
Teaching methods
lectures follwed by brief discussions
Assessment methods
Written test is required. At least 50% of correct answers is required to pass the exam. Oral examination can be used to specify classification.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Studenti profilující své studium směrem k využití molekulárně biologických metod si mohou namísto předmětu Bi4010 zapsat jednu z dvojic předmětů Bi4020 + Bi4020c nebo Bi4020 + Bi4035, která jim bude uznána jakožto předmětový ekvivalent Bi4010.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (spring 2018, recent)
  • Permalink: https://is.muni.cz/course/sci/spring2018/Bi4010