IC008 Chemistry of the Platinum Group Metals

Faculty of Science
Autumn 2006
Extent and Intensity
0/0. Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination).
Teacher(s)
Prof. Lars Ivar Elding (lecturer)
Guaranteed by
prof. RNDr. Přemysl Lubal, Ph.D.
Chemistry Section – Faculty of Science
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
The course will give a general overview of the chemistry of these metals, with special emphasis on their reactions and their applications in homogeneous catalysis and bio-inorganic chemistry, and with practical examples taken from the experience of the lecturer.
Syllabus
  • 1. The metals: Occurrence, separation, refinement, properties
  • 2. Coordination compounds: chemical bonding, structures, stabilities, reactivities.
  • 2.1 Werner complexes
  • 2.2 Organometallic compounds the Chatt-Duncanson model for olefin complexes
  • 2.3 Role of platinum complexes in the development of the hard/soft model for chemical bonding
  • 3. Ligand exchange and substitution processes.
  • 3.1 Thermodynamic stability and the trans-influence
  • 3.2 Reactivity and the trans-effect
  • 3.3 Aqua and other solvento complexes. Synthesis of solvento complexes
  • 3.4 NMR studies of exchange processes
  • 3.5 Cryo-temperature studies of extremely fast substitutions of ethene complexes
  • 3.6 Fast reactions of aryl- and silyl platinum(II) complexes
  • 3.7 Associative, interchange and dissociative exchange/substitution processes. The use of variable temperature (activation entropies) and high-pressure (activation volumes) for deduction of mechanism.
  • 3.8 Isokinetic relationships. The kinetics for reversible complex formation between carboxylic acids and palladium(II)
  • 4. Electron transfer reactions: bridged and outer-sphere electron transfer
  • 4.1 Accelerated substitution processes at platinum(IV). The Basolo-Pearson mechanism for platinum(II) catalyzed substitution. Ligand accelerated reactions.
  • 4.2 Reduction of anti-cancer active platinum (IV) prodrugs by bio-ligands such as ascorbate and glutathione
  • 5. Reactions between anticancer-active platinum(II) compounds and biological molecules.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught only once.
The course is taught: in blocks.
Note related to how often the course is taught: 1 týden.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2006/IC008