Bi6051 Molecular Physiology of Animals

Faculty of Science
Autumn 2008
Extent and Intensity
2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)
doc. RNDr. Antonín Lojek, CSc. (lecturer)
Mgr. Jiří Pacherník, Ph.D. (lecturer)
Mgr. Jiřina Medalová, Ph.D. (lecturer)
doc. Mgr. Karel Souček, Ph.D. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
prof. RNDr. Jan Vondráček, Ph.D. (lecturer)
Mgr. Pavel Krejčí, Ph.D. (lecturer)
doc. RNDr. Martin Vácha, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.
Timetable
Thu 15:00–16:50 BFU
Prerequisites
Bi6082 Bakalářská státní závěrečná zkouška z Obecné biologie
Good knowledge of biochemistry, cell and molecular biology are supposed.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 12 fields of study the course is directly associated with, display
Course objectives
The course is intended for advanced students of animal physiology and immunology as well as for students oif molecular biology, biochemistry, ecotoxicology and other field of study with experimental orientation. It functions as superstructure clarifying experimental approaches (Ideological and methodological) leading to explaining and deeper understanding of selected physiological and immunological processes and their regulation. The course is focused to special questions associated especially with mechanisms of signal transduction within inter- and intracellular communication regulating cytokinetics, i. e.cell proliferation, differentiation and death of specific cell types ( stem, hemopoietic, immune, intestinal). Attention is paid to mechanisms of the effects of oxidative metabolism products and neural and cellular processes of animal sensory transduction.
Main objectives are (in succession to other courses of animal physiology and immunology) extending and detail clarifying of cell processes and functions with stress on understanding of experimental approaches and logical relations explaioning the way of gaining experimental results including working hypotheses.
Selested items described in Sylabus specify in detail main topics of interest.
Syllabus
  • 1. Neural and cellular processes of sensory transduction – how sensory stimuli enter the nervous system.
  • 2. Biology of Vitamin A, its role in animal physiology - uptake, metabolism, signal transduction, and its role in ontogenesis and homeostasis
  • 3. Biology of gp130/IL-6 cytokine family - its role in ontogenesis and homeostasis, signal transduction
  • 4. Model interaction of nuclear receptors and enzymatic systems
  • 5. Molecular mechanisms of apoptosis induced by tumor necrosis (TNF) family proteins
  • 6. Functional diversity of microtubules: their function and regulation
  • 7. Transforming growth factor - β - diversity of signaling and function.
  • 8. Physiological role of tissue specific isoforms of nitric oxide.
  • 9. Mechanism of action of fatty acids in the intestine and their association with inflammatory and neoplastic diseases
  • 10, 11. Fibroblast growth factor: Anatomy of the signaling system and its function in development and disease.
  • 12. Changes of transcription factor NF-kappaB in relationship with cytokinetics
Literature
  • Handbook of cell signaling, Vol. 1-3, Eds. R.A. Bradshaw, E.A. Dennis, Elsevier Science, 2004
  • HANCOCK, John T. Cell signalling. 2nd ed. Oxford: Oxford University Press, 2005, xix, 296. ISBN 0199264678. info
  • HELMREICH, E.J.M. The Biochemistry of Cell Signalling. Oxford: Oxford University Press, 2001, 328 pp. info
  • NELSON, John. Structure and function in cell signalling. Chichester: John Wiley & Sons, 2008, xx, 389. ISBN 9780470025512. info
  • Nutritional oncology. Edited by David Heber. 2nd ed. Amsterdam: Elsevier-Academic Press, 2006, xxiv, 822. ISBN 0120883937. info
  • Transcription factors. Edited by J. Locker. Oxford: BIOS, 2001, xvi, 336. ISBN 1859961827. info
  • Apoptosis in health and disease. Edited by Robert R. Ruffolo - Frank Walsh. [1st ed.]. [Amsterdam]: Harwood Academic Publishers, 2000, xvii, 249. ISBN 9058230864. info
  • Apoptosis and cancer therapy, from cutting-edge science to novel therapeutic concepts, Vol. 1 and 2, WILEY-VCH Verlag GmbH&KGaA, Weinheim, Eds. K-M. Debatin and S. Fulda, 2006
  • TGF-β and related cytokines in inflammation. Edited by Samuel N. Breit - Sharon M. Wahl. Basel: Birkhauser-Verlag, 2001, xiii, 201. ISBN 3764360097. info
  • Interleukin-6-type cytokines. Edited by Andrzej Mackiewicz. [1st ed.]. New York: New York Academy of Sciences, 1995, xv, 522 s. ISBN 0-89766-931-2. info
  • Nitric oxide. Edited by Lester Packer. San Diego: Academic Press, 1996, xxx, 528. ISBN 0121821706. info
  • Nitric oxide :principles and actions. Edited by Jack Lancaster. [1st ed.]. San Diego: Academic Press, 1996, xv, 355 s. ISBN 0-12-435555-2. info
  • FAIN, Gordon L. Sensory transduction. 1st ed. Sunderland, Mass.: Sinauer Associates, 2003, xi, 340. ISBN 0878931716. info
  • Special selected reviews and papers for presented topics
Assessment methods
Lectures and class discussion.
Final written exam.
Language of instruction
Czech
Follow-Up Courses
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015.
  • Enrolment Statistics (Autumn 2008, recent)
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