Bi6901 Structural Biology - practice

Faculty of Science
Autumn 2010
Extent and Intensity
0/2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: z (credit).
Teacher(s)
prof. Mgr. Jiří Damborský, Dr. (lecturer)
prof. RNDr. Zbyněk Prokop, Ph.D. (lecturer)
doc. Mgr. Radka Chaloupková, Ph.D. (lecturer)
Guaranteed by
prof. Mgr. Jiří Damborský, Dr.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. Mgr. Jiří Damborský, Dr.
Prerequisites
The ability to communicate in English.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
This practise will be organized in the small groups of students and will focus on structural biology. At the end of this course, the students will be able independently to design experiments, conduct measurements and interpret data. They will learn how to critically access and communicate the results. During the journal clubs, students will learn interesting news from the field.
Syllabus
  • Prediction of Protein Structure and Function by Bioinformatics Tools
  • Computer-Assisted Design of Proteins with Optimized Catalytic Properties
  • Engineering and Evolution of Proteins, Expression and Purification
  • Functional and Structural Characterization of Proteins by Steady-State and Transient Kinetics, Circular Dichroism Spectroscopy and Microcalorimetry
Literature
    recommended literature
  • DOBES, Petr, Jan KMUNÍČEK, Vladimír MIKEŠ and Jiří DAMBORSKÝ. Binding of Fatty Acids to b-Cryptogein: Quantitative Structure-Activity Relationships and Design of Selective Protein Mutants. Journal of Chemical Information and Modeling. USA, 2004, 44-6, No 44, p. 2126-2132. ISSN 1549-960X. URL info
  • DAMBORSKÝ, Jiří. A mechanistic approach to deriving Quantitative Structure-Activity Relationship models for microbial degradation of organic compounds. SAR and QSAR in Environmental Research. 1996, vol. 5, No 1, p. 27-36. ISBN1029046. URL info
Teaching methods
The lecture is taught by interpretation of powerpointovým templates prepared according to textbooks, monographs and articles. Templates are shown during the lecture, the contents are explained and accompanied by teacher commentary.
Assessment methods
discussions, journal clubs
Language of instruction
English
Further Comments
The course is taught each semester.
The course is taught: every week.
The course is also listed under the following terms Spring 2011 - only for the accreditation, Autumn 2010 - only for the accreditation, Spring 2009, Autumn 2009, Spring 2010, Spring 2011, Autumn 2011, Autumn 2011 - acreditation, spring 2012 - acreditation, Spring 2013.
  • Enrolment Statistics (Autumn 2010, recent)
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