aZLFA0722p Pharmacology II - lecture

Faculty of Medicine
autumn 2024
Extent and Intensity
1/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Alena Máchalová, Ph.D. (lecturer)
Carlos Daniel Ferreira Fonseca, MSc. (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 24. 9. 15:00–16:40 Virtuální místnost, Tue 1. 10. 15:00–16:40 Virtuální místnost, Tue 8. 10. 15:00–16:40 Virtuální místnost, Tue 15. 10. 15:00–16:40 Virtuální místnost, Tue 22. 10. 15:00–16:40 Virtuální místnost, Tue 29. 10. 15:00–16:40 Virtuální místnost, Tue 5. 11. 15:00–16:40 Virtuální místnost, Tue 12. 11. 15:00–16:40 Virtuální místnost
Prerequisites (in Czech)
aZLFA0621c Pharmacology I - pract. && aZLPA0622c Pathology II - practice && aZLPF0622c Pathophysiol. II - practice && aZLOR0641c Orthodontics I -pract. && aZLPD0631c Periodontology I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum.
Learning outcomes
Students are able to understand main pharmacological mechanisms of drug actions leading to therapeutic, adverse and toxic effects of drugs and eventually their combinations. They will be able to recognize main drug classes and pharmacological profiles of representative drugs from groups of drugs selected in the curriculum with the special attention paid to preparations used in dentistry.
Syllabus
  • 1. Analgesics of morphine type. Pharmacotherapy of pain. Non-opioid analgesics, non-steroidal anti-inflammatory drugs. Classification, targets of effects, mechanisms of action, topically applied anti-inflammatory drugs.
  • 2. Local and general anaesthetics Overview, classification and mechanisms of action, side effects.
  • 3. H1 antihistamines, antiasthmatics Classification and clinical use of H1 antihistamines. Pathophysiology of bronchial asthma, sites and mechanisms of action of antiasthma drugs.
  • 4. Introduction to psychopharmacology. Antipsychotics, anxiolytics, hypnosedatives – mechanisms of action, side effects. Antidepressant drugs. Classification, mechanisms of action, adverse effects.
  • 5. Antihypertensives. Diuretics, antiadrenergics, vasodilators, combinative pharmacotherapy. Pharmacotherapy of ischemic heart disease.
  • 6. Antidiabetic drugs. Therapy of type 1 and 2 DM. Insulins, peroral antidiabetics. Treatment of selected GIT disorders.
  • 7. Specifities of pharmacotherapy in pediatric population, in elderly, in pregnant women and during lactation.
  • 8. Drug interactions at different levels.
Literature
    required literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN, Emma S. J. ROBINSON and James FULLERTON. Rang & Dale's pharmacology / James M. Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEvan, Emma Robinson, James Fullerton. Tenth edition. London: Elsevier, 2024, xvii, 850. ISBN 9780323873963. info
    not specified
  • Lippincott's Illustrated Reviews : Pharmacology, 4th Ed., Harvey, Richard A. - Champe, Pamela C. - Finkel, Richard - Cubeddu, Luigi - Clarke, Michelle A. 2008. 560 s. ISBN-10: 0-7817-7155-2, ISBN-13: 978-0-7817-7155-9
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
Bookmarks
https://is.muni.cz/ln/tag/LF:aZLFA0722p!
Teaching methods
Presentatios of lectures will be provided in e-form as commented presentations. Students are expected to follow the provided lectures.
Assessment methods
The final exam will be in the oral form.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
Information for students:

Students are asked to answer three randomly chosen questions dealing with the topics listed in synopses: Pharmacology I Lectures, Pharmacology I Practicals, Pharmacology II Lectures, Pharmacology II Practicals.

QUESTIONS ON GENERAL PHARMACOLOGY:

Routes of administration - overview, characteristics

Basic pharmacokinetic parameters and processes (overview)

Drug absorption, "first pass" effect

Biovailability of drugs

Drug distribution, volume of distribution

Drug elimination

Drug biotransformation, phases of biotransformation

Effect of environment pH and pKa of drugs on the drug transfer across biological membranes

Enzyme inhibition and induction

Drug excretion

Pharmacokinetics of single, repeated and continous drug administration

Pharmacokinetics of drug oral and parenteral administration

Drug dosage forms - overview and influence on pharmacokinetics

Therapeutic drug monitoring

Dose and effect, types of doses

Pharmacogenetics, pharmacogenetic polymorphism

Mechanisms of drug action - overview, non specific mechanisms of drug action

Specific mechanisms of drug action - the target structures, on which the drug act

Adverse drug reactions (types, categories)

Drug receptors theory - types of receptors

Tolerance, tachyphylaxis

Drug addiction

Therapeutic index, therapeutic range

Influence of concomitant diseases on drug effect, polypragmasia

Drug allergy (hypersensitivity), idiosyncrasy

Drug interactions- overview, pharmacokinetic interactions

Drug interactions- overview, pharmacodynamic interactions

Factors influencing the drug effect (related to drug, related to organism)

Pharmacoterapy in pregnancy, drug teratogenicity

Pharmacotherapy in breastfeeding women, in pediatric population

Pharmacoterapy in elderly

Pharmacology, sub-branches, origin of drugs, drug names

Pharmacopoeia

Rational pharmacotherapy, drug anamnesis, compliance

Development of a new drug (Drug life cycle)

Preclinical and clinical evaluation of drugs

Pharmacovigilance

General principles of drug poisoning therapy, specific antidotes and their mechanisms of action

Principles of biological therapy - technology, requirements on the quality, registration, biosimilars

QUESTIONS ON SPECIAL PHARMACOLOGY:

Antimycotics

Antivirotics

Drugs with the topic action used in stomatology - overview

Antiinfective drugs used in stomatology

Disinfectants and antiseptics

Drugs with the topic action - dermatologics, drugs used in ORL

Principles of antibiotic therapy - overview, mechanisms of action, resistance

Antibiotics for topic use

Penicillines

Cephalosporins and other beta-lactams

Aminoglycosides

Macrolides

Sulphonamides

Tetracyclines

Quinolones and nitroimidazoles

Non-steroidal antiinflammatory drugs + Analgesics - antipyretics

Drugs used in gout

General anaesthetics

Premedications and supplement general anaesthesia, analgosedation, neuroleptanalgesia

Central and peripheral myorelaxants

Ester-type local anaesthetics

Amide-type local anaesthetics

Types and techniques of local anaesthesia

Pharmacoterapy of anaphylactic shock

Antitussives, expectorants

Hypolipidemics, lipid-lowering drugs

Drugs used in heart failure

Histamine H1-blockers

Antiasthmatics

Antihypertensives - overview + ACE inhibitors, sartans, renine antagonists

Antihypertensives - overview + diuretics, alpha1-lytics

Antihypertensives - overview + beta-blockers, central antihypertensives

Antiulcer drugs

Laxatives, antidiarrhoics

Antiemetics, prokinetics

Spasmolytics, digestives

Vitamins AEDK

Hydrophilic vitamins

Psychopharmacs - overview, classification

Hypnosedatives

Antiepileptic drugs

Antipsychotics

Anxiolytics

Antidepressants

Nootropics, drugs affecting cognitive functions

Psychostimulants, hallucinogenic and delirogenic drugs

Antidysrhytmics

Cardiotonics, inotropic drugs

Alkylating cytostatics and other impacts of DNA

Antimetabolites + hormonal therapy in oncology

Glucocorticoids

Thyroid + anti-thyroid drugs

Drugs used in osteoporosis

Sex hormones - HRT, contraceptives

Uterotonics, tocolytics

Insulins

Antidiabetics for the treatment of type 2 DM

Anticoagulants, antiplatelet drugs

Antithrombotics, trombolytics

Opioid analgesics

Drugs causing addiction and pharmacological possibilities of addiction treatment

Drugs affecting ANS - neurotransmission, receptors of ANS, basic overview

Sympathomimetic agents - basic effects and classification - direct sympathomimetics

Sympathomimetic agents - basic effects and classification - indirect sympathomimetics

Sympatholytic agents - basic effects and classification - direct sympatholytics

Sympatholytic agents - basic effects and classification - indirect sympatholytics

Cholinomimetic agents - basic effects and classification - direct cholinomimetics

Cholinomimetic agents - basic effects and classification - indirect cholinomimetics

Cholinolytic agents - basic effects and classification - direct cholinolytics (parasympatholytics, ganglioplegics)

LIST OF GENERIC NAMES –„ESSENTIAL DRUGS“:

pantoprazole

famotidine

atropine

butylscopolamine

fenpiverine, pitofenone

metoclopramide

ondansetron

lactulose

insulin lispro

metformin

glibenclamide

warfarin

enoxaparin

acetylsalicylic acid

digoxin

propafenone

amiodarone

epinephrine

norepinephrine

dopamine

ephedrine, pseudoephedrine

nitroglycerin

methyldopa

clonidine

urapidil

hydrochlorothiazide

furosemide

metoprolol

labetalol

nifedipine

verapamil

enalapril

losartan

atorvastatin

ezetimibe

nystatin

ketoconazole

methylergometrine

hexoprenaline

alfuzosin

oxytocin

dexamethasone

prednisone

doxycycline, chloramphenicol

amoxicillin

phenoxymethylpenicillin

oxacillin

piperacillin, co-piperacillin

cefuroxime

cotrimoxazole

clarithromycin

gentamicin

ciprofloxacin

fluconazole

aciclovir

zidovudine

cyclophosphamide

methotrexate

6-mercaptopurine

5-fluorouracil

paclitaxel

doxorubicin

cisplatin

trastuzumab

tamoxifen

interferon alpha

ibuprofen

diclofenac

indomethacin

nimesulide

suxamethonium

allopurinol

alendronic acid

lidocaine

procaine

trimecaine

articaine

sevoflurane

thiopental

propofol

dihydrocodeine

sufentanil

piritramide

tramadol

paracetamol (acetaminophen)

metamizole

sumatriptan

valproic acid

gabapentin

haloperidol

risperidone

olanzapine

lithium

diazepam

alprazolam

zolpidem

midazolam

escitalopram

amitriptyline

bupropion

methylphenidate

donepezil

physostigmine

methadone

buprenorphine

betahistine

oxymetazoline, xylometazoline

phenylephrine

salbutamol

fenoterol

ipratropium bromide

nedocromil

acetylcysteine

bromhexine

codeine

butamirate

bisulepine

cetirizine

desloratadine

pilocarpine

timolol

tropicamide

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
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