BLKKH0411p Clinical Haematology - lecture

Faculty of Medicine
spring 2020
Extent and Intensity
0/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Ludmila Bourková (lecturer)
MUDr. Alena Buliková, Ph.D. (lecturer)
MUDr. Jarmila Kissová, Ph.D. (lecturer)
MUDr. Zdeněk Kořístek, Ph.D. (lecturer)
prof. MUDr. Miroslav Penka, CSc. (lecturer)
MUDr. Gabriela Romanová, Ph.D. (lecturer)
Mgr. Lucie Říhová, Ph.D. (lecturer)
MUDr. Petr Smejkal, Ph.D. (lecturer)
RNDr. Jiřina Zavřelová (lecturer)
Michaela Gregorovičová (assistant)
Guaranteed by
prof. MUDr. Miroslav Penka, CSc.
Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Contact Person: MUDr. Alena Buliková, Ph.D.
Supplier department: Department of Laboratory Methods – Departments of Non-medical Branches – Faculty of Medicine
Prerequisites
BLKMB011p Mol.andCell.Biol.-lect.
Basic principles of laboratory practice. Human physiology and pathophysilogy concerning to hematopoesis, blood composition, blood cells and blood coagulation and hemostasis.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
This course includes information about the origin, development, structure and function of the system of hematopoietic cells and organs as well as of the blood clotting system. Both of them are described not only in health but also during various diseases inherited and acquired. Students will receive information summarizing pathophysiologic mechanisms, clinical and mainly laboratory findings in hematologic diseases and laboratory assays serving for treatment’s maintenance. The knowledge will allow students to interpret results obtained during hematological laboratory examination for diagnosis establishing and/or for differential diagnoses.
Learning outcomes
Basic principles of hematologic assays, incl. good laboratory practice. Student is able to: -indentify basic types of blood elements of peripheral blood and bone marrow, -interpret findings CBC blood count, -provide basic coagulation assays, -interpret basic coagulation tests.
Syllabus
  • Origin and development of blood cells.
  • Basic principles of blood coagulation.
  • Plasmatic clotting factors, their physiology. Inherited bleeding disorders.
  • Primary hemostasis, platelet plug formation and its abnormalities.
  • Basic principles of anti-platelet therapy.
  • Inherited thrombophilias, anti-thrombotic treatment and its monitoring.
  • Acquired disorders of blood clotting.
  • Red cell disorders.
  • Myeloproliferative neoplasms.
  • Acute leukaemias.
  • Myelodyspastic syndrome.
  • Lymphoproliferative disorders.
  • Flow cytometry and molecular genetic assays for diagnosis of hematology diseases.
  • Therapeutic aphaeresis, basic principles of hemopoietic cells transplantation.
Literature
    required literature
  • PENKA, Miroslav, Eva TESAŘOVÁ, Jan BLATNÝ, Ludmila BOURKOVÁ, Alena BULIKOVÁ, Zbyněk ČECH, Magdalena JELÍNKOVÁ, Jarmila KISSOVÁ, Zdeněk KOŘÍSTEK, Lucie KOVÁŘOVÁ, Petr KUGLÍK, Miroslava MATÝŠKOVÁ, Jan NOVOTNÝ, Šárka POSPÍŠILOVÁ, Markéta SLÁNSKÁ, Petr SMEJKAL, Irena TRNAVSKÁ, Ondřej ZAPLETAL and Jiřina ZAVŘELOVÁ. Hematologie a transfuzní lékařství I (Haematology and Transfusion Medicine I). 1.vyd. Praha: Grada, 2011, 488 pp. ISBN 978-80-247-3459-0. info
    not specified
  • SLAVÍČKOVÁ, Eva. Hematologie a transfuzní lékařství. Edited by Miroslav Penka. 1, vyd. Praha: Grada, 2012, 192 s. ISBN 9788024734606. info
  • PECKA, Miroslav. Laboratorní hematologie v přehledu : fyziologie a patofyziologie krevní buňky. 1. vyd. Český Těšín: FINIDR, 2006, 304 s. ISBN 8086682021. info
  • PECKA, Miroslav. Laboratorní hematologie v přehledu : fyziologie a patofyziologie hemostázy. 1. vyd. Český Těšín: FINIDR, 2004, 237 s. ISBN 808668203X. info
  • PECKA, Miroslav. Přehled laboratorní hematologie. Bílá krevní řada, krevní destičky. [1. vyd.]. Praha: Galén, 1996, 132 s. ISBN 8085824434. info
  • Přehled laboratorní hematologie 1 :Krvetvorba. Červená krevní řada. Edited by Miroslav Pecka. [1. vyd.]. Praha: Galén, 1995, 141 s. ISBN 80-85824-28-0. info
Teaching methods
Students will attend two hours long lecture ones a week (14 per semester). Participation in lectures is optional.
Assessment methods
The course is closed by an examination which is divided into practical and an oral part. Practical part includes testing of haemostaseology and hematologic morphology. In the haemostaseology student performs basic coagulation test, interprets coagulation laboratory finding (four basic coagulation tests) and orally answers the selected question which is aimed at understanding the laboratory investigations in blood clotting. In question from the morphological laboratory, the student evaluates 6 microscopic findings (in digital processing) and orally answers the selected question which is aimed at understanding the laboratory investigations in morphological diagnosis in haematology. In oral part student elects two questions, one of which is focused on morfological laboratory investigation, the second one concerns the blood coagulation. Each question (two practical and two theoretical ones) is grades A-F. No grade F is necessary condition for passing an examination.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught: in blocks.
General note: Všechny formy kontaktní výuky předmětu vyjma přednášek jsou povinné.Všechny formy kontaktní výuky předmětu vyjma přednášek jsou povinné.
Information on the extent and intensity of the course: 15.
The course is also listed under the following terms Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019.
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