VLBI0121p Medical Biology I - lecture

Faculty of Medicine
autumn 2024
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. RNDr. Ondřej Slabý, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 18. 9. 14:30–16:10 B22/116 aula, Wed 25. 9. 14:30–16:10 B22/116 aula, Wed 2. 10. 14:30–16:10 B22/116 aula, Wed 9. 10. 14:30–16:10 B22/116 aula, Wed 16. 10. 14:30–15:50 B11/114, Wed 23. 10. 14:30–16:10 B22/116 aula, Wed 30. 10. 14:30–16:10 B22/116 aula, Wed 6. 11. 14:30–16:10 B22/116 aula, Wed 13. 11. 14:30–16:10 B22/116 aula, Wed 20. 11. 14:30–16:10 B22/116 aula, Wed 27. 11. 14:30–16:10 B22/116 aula, Wed 4. 12. 14:30–16:10 B22/116 aula, Wed 18. 12. 14:30–16:10 B22/116 aula
Prerequisites
Knowledge of high-school biology on the level of Overview of High School Biology (https://is.muni.cz/auth/do/med/el/overview/overview_ENG.qwarp) or similar, and knowledge of all previous lectures and practical classes of the subject. Expected knowledge for each lecture is specified in the course syllabus.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding of cellular and molecular biology with a special focus on the potential application of acquired knowledge in clinical medicine
Learning outcomes
After completing the course, the student will be able to:
- describe and explain the organization of the prokaryotic and eukaryotic genome, DNA replication
- explain elementary processes taking place in cells (gene expression, inter- and intra-cellular communication, cell differentiation, cell division, cell death) and their purposes
- explain the relationship between malfunctioning cellular processes and the development of diseases
- explain how gene mutations and chromosome aberrations cause human diseases and illustrate it with examples
Syllabus
  • 1. Introduction to the Medical Biology
  • 2. Fundamental Chemistry of Life – Chemical Components of Cells, Protein Structure and Function
  • 3. Architecture and Function of Eukaryotic Cell – Membrane System, Organelles, Cytoskeletal System
  • 4. Genome Organization – Nucleic Acids, Chromosome Structure, DNA replication
  • 5. Genome Stability and Instability – DNA damage, Mutations, DNA repair and Defects in DNA repair
  • 6. Gene Expression I – Central Dogma of Molecular Biology, Gene Structure, Transcription and RNA modification
  • 7. Gene Expression II – Translation, Genetic Code, Post-translational Modifications
  • 8. Regulation of Gene Expression
  • 9. Cellular Communication – General Principles of Cell Signalling, Receptors, Signalling Pathways
  • 10. Cell Division – Mitosis and Meiosis
  • 11. Cell Cycle and Principles of its Regulation
  • 12. Cell Death
  • 13. Cells and Tissue – Cell Junctions, Adhesive Molecules and Extracellular Matrix
Literature
    required literature
  • SLABÝ, Ondřej. Lékařská biologie II. Genetika a molekulární medicína (Medical Biology II. Genetics and molecular medicine). 1st ed. Brno: Masarykova univerzita, 2023, 227 pp. ISBN 978-80-280-0338-8. info
  • SLABÝ, Ondřej. Lékařská biologie. 1. vydání. Brno: Masarykova univerzita, 2022, 268 stran. ISBN 9788028000608. info
    recommended literature
  • ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
  • D. Peter Snustad Michael J. Simmons. Genetika. Brno, 2017. ISBN 9788021086135. info
Teaching methods
lecture every week
Assessment methods
Without examination - Medical Biology I is continued with Medical Biology II which is completed with an oral exam.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/med/podzim2024/VLBI0121p/index.qwarp
Lectures take place every week. We recommend following the Interactive syllabus of the course where students can find all relevant information (schedule, substitutions, public holidays etc.), lecture´s presentations, and also links to animations and videos relevant to the topic: https://is.muni.cz/auth/el/med/podzim2024/VLBI0121p/index.qwarp
The course is also listed under the following terms Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
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