LF:VSLC011p Med.Chem.- lecture - Course Information

VSLC011p Medical Chemistry-lecture

Extent and Intensity

2/0. 4 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
doc. MUDr. Jaromír Sláma, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Jaroslava Tallová, CSc. (lecturer)
Mgr. Milena Matejovičová, Ph.D. (assistant)

Guaranteed by

prof. MUDr. Vladimír Palyza, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• General Medicine (programme LF, M-VL)

Syllabus

• Information concerning medical chemistry. The basic chemical terms: substances, particles, amount of substance, some properties of a single particle and molar quantities. Electron configurations in atoms. Types of bonds, electronegativity. Non-covalent bonds and attraction forces.
• Chemical reactions, kinetics, chemical equilibrium. The driving force of chemical reactions, free Gibbs energy.
• Solutions of substances. Dissociation of electrolytes, the equilibria in electrolyte solutions.
• Protolytic reactions: acids and bases, pH values, hydrolysis of salts, buffers.
• Oxidation-reduction reactions, redox potentials, the e.m. force of a voltaic cell and the relation to the reaction free energy change.
• Essential macroelements important for living matter, general properties of them and of some of their compounds.
• Carbon compounds: their constitution, configuration, isomerism, and conformation. Types of organic compounds, the principals of nomenclature. Hydrocarbons, major types, structures, reactivity.
• Derivatives of hydrocarbons: alcohols, thioalcohols, phenols, carbonyl compounds, and carboxylic acids.
• Substituted carboxylic acids and derivatives of the acids (esters, amides, anhydrides, halides).
• Amines and the other derivatives of hydrocarbons.
• Heterocyclic compounds and biochemically important derivatives. Alkaloids.
• Structures and properties of monosaccharides. Simple sugar derivatives. Oligosaccharides, polysaccharides.
• Heteroglycosides. Nucleosides, nucleotides, structures of nucleic acids.
• Fatty acids and alcohols in lipids. Triacylglycerols and waxes. Phospholipids and glycolipids.
• Icosanoids. Isoprenoids. Steroids, structures of representative compounds.
• Standard and other alpha-amino acids, structures and common properties, polarity. Peptides, some groups of peptides exhibiting biological activity.
• Proteins, main features of the structure of globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins, haem and other tetrapyrrols.

Literature

• TÁBORSKÁ, Eva, Jaromír SLÁMA, Hana BOCHOŘÁKOVÁ, Petr KAPLAN, Ingrid WILHELMOVÁ, Hana PAULOVÁ, Jaroslava TALLOVÁ and Josef TOMANDL. Lékařská chemie I (Medical Chemistry I). 1st ed. Brno: Masarykova Univerzita v Brně, 2001, 134 pp. ISBN 80-210-2534-4. info
• DOSTÁL, Jiří, Petr KAPLAN, Hana BOCHOŘÁKOVÁ, Hana PAULOVÁ, Jaromír SLÁMA, Jiří SLANINA, Jaroslava TALLOVÁ, Josef TOMANDL, Marie TOMANDLOVÁ and Ingrid WILHELMOVÁ. Lékařská chemie II. Bioorganická chemie (Medical chemistry II. Bioorganic chemistry). 1st ed. Brno: Masarykova univerzita, 2001, 223 pp. ISBN 80-210-2731-2. info
• HOLUM, John R. Elements of General and Biological Chemistry. 8. ed. New York: John Wiley & Sons, 1991, 425 s., 53. ISBN 0-471-51757-7. info
• Organic chemistry :a short course. Edited by Harold Hart. 9th ed. Boston: Houghton Mifflin Company., xx, 572 s. ISBN 0-395-70838-9. info

Language of instruction

Czech

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

• Enrolment Statistics (Autumn 2003, recent)
  
• Permalink: https://is.muni.cz/course/med/autumn2003/VSLC011p