LF:VSLC011p Med. Chem. lecture - Course Information
VSLC011p Medical Chemistry - lecture
Faculty of MedicineAutumn 2012
- Extent and Intensity
- 2/0. 4 credit(s). Type of Completion: zk (examination).
- Teacher(s)
- doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
PharmDr. Lenka Adámková, Ph.D. (assistant)
RNDr. Hana Bochořáková (assistant)
Ing. Martina Čarnecká, Ph.D. (assistant)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Mgr. Jana Kantorová (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Milena Matejovičová, Ph.D. (assistant)
Ing. Jitka Melounová, Ph.D. (assistant)
Lenka Nerudová (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Ing. Jana Simonová, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant) - Guaranteed by
- prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine - Timetable
- Mon 9:30–11:20 B22/116 aula
- Timetable of Seminar Groups:
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Nutritive therapist (programme LF, B-SZ)
- General Medicine (eng.) (programme LF, M-VL)
- General Medicine (programme LF, M-VL) (2)
- Course objectives
- Graduate in chemistry has knowledge that is necessary for understanding of chemical principles applied in further study subjects, especially in biochemistry.He/she understand solution properties and basic physico-chemical laws. Describes the properties of elements and inorganic compounds important for medicine, nutrition and toxicology. Discuses the structure of compounds and reactions taking part in metabolism and organic compounds that have importance in toxicology.
- Syllabus
- Information concerning medical chemistry. The basic chemical terms: substances, particles, amount of substance, some properties of a single particle and molar quantities. Electron configurations in atoms. Types of bonds, electronegativity. Non-covalent bonds and attraction forces.
- Chemical reactions, kinetics, chemical equilibrium. The driving force of chemical reactions, free Gibbs energy.
- Solutions of substances. Dissociation of electrolytes, the equilibria in electrolyte solutions.Precipitation reactions.
- Protolytic reactions: acids and bases, pH values, hydrolysis of salts, buffers.
- Oxidation-reduction reactions, redox potentials, the e.m. force of a voltaic cell and the relation to the reaction free energy change.
- Essential macroelements important for living matter, general properties of them and of some of their compounds.
- Carbon compounds: their constitution, configuration, isomerism, and conformation. Types of organic compounds, the principals of nomenclature. Hydrocarbons, major types, structures, reactivity.
- Derivatives of hydrocarbons: alcohols, thioalcohols, phenols, carbonyl compounds, and carboxylic acids.
- Substituted carboxylic acids and derivatives of the acids (esters, amides, anhydrides, halides).
- Amines and the other derivatives of hydrocarbons.
- Heterocyclic compounds and biochemically important derivatives. Alkaloids.
- Structures and properties of monosaccharides. Simple sugar derivatives. Oligosaccharides, polysaccharides.
- Heteroglycosides. Nucleosides, nucleotides, structures of nucleic acids.
- Fatty acids and alcohols in lipids. Triacylglycerols and waxes. Phospholipids and glycolipids.
- Icosanoids. Isoprenoids. Steroids, structures of representative compounds.
- Standard and other alpha-amino acids, structures and common properties, polarity. Peptides, some groups of peptides exhibiting biological activity.
- Proteins, main features of the structure of globular, fibrous, and membrane proteins. Glycoproteins. Haemoproteins, haem and other tetrapyrrols.
- Literature
- required literature
- TÁBORSKÁ, Eva, Hana BOCHOŘÁKOVÁ, Jiří DOSTÁL, Hana PAULOVÁ, Jaromír SLÁMA, Jiří SLANINA, Jaroslava TALLOVÁ and Josef TOMANDL. Lékařská chemie I. Obecná a anorganická chemie. 2. přepracované. Brno: Masarykova univerzita, 2005, 156 pp. učební text. ISBN 80-210-3790-3. info
- DOSTÁL, Jiří, Hana BOCHOŘÁKOVÁ, Hana PAULOVÁ, Jaromír SLÁMA, Jiří SLANINA, Jaroslava TALLOVÁ, Josef TOMANDL and Marie TOMANDLOVÁ. Lékařská chemie II - Bioorganická chemie. 2. zcela přepracované. Brno: Masarykova univerzita, 2005, 166 pp. ISBN 80-210-3789-X. info
- TÁBORSKÁ, Eva, Jaromír SLÁMA, Hana BOCHOŘÁKOVÁ, Jiří DOSTÁL, Hana PAULOVÁ, Jiří SLANINA, Jaroslava TALLOVÁ and Josef TOMANDL. Medical Chemistry I. General and Inorganic Chemistry. 1st ed. Brno: Masarykova univerzita, 2006, 150 pp. učební text. ISBN 80-210-4091-2. info
- DOSTÁL, Jiří, Hana BOCHOŘÁKOVÁ, Hana PAULOVÁ, Jaromír SLÁMA, Jiří SLANINA, Eva TÁBORSKÁ, Jaroslava TALLOVÁ, Josef TOMANDL and Marie TOMANDLOVÁ. Medical Chemistry II - Bioorganic Chemistry. 1st ed. Brno: Masarykova univerzita, 2006, 164 pp. učební text. ISBN 80-210-4128-5. info
- Teaching methods
- Teaching form are lectures. Supplementary subjects are seminars and practicals (VSLC011c and VSLC011c).
- Assessment methods
- Student must have course-unit credit of seminar and practicals in the day of exam.
Examination from Medical chemistry is only written. The test consists from two parts. The first part is solved on computers in the computer room of Department of Biochemistry: calculations (concentration, pH, buffers, osmotic pressure) – see seminars simple questions (multiple choice or free answer) structural formulas (essential organic and inorganic compounds).
The second part is written and is focused on the active knowledge of structural formulas of the most important compounds, expression of important biochemical reactions by chemical equations and the ability to formulate the basic physico-chemical relationships or to draw graphs. For detailed instructions see Study materials - Information about exam. - Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course is taught annually.
Information on the extent and intensity of the course: celkem 30 hodin.
- Enrolment Statistics (Autumn 2012, recent)
- Permalink: https://is.muni.cz/course/med/autumn2012/VSLC011p