VLFA0722p Pharmacology - lectures

Faculty of Medicine
Autumn 2008
Extent and Intensity
2/0/0. 5 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: -.
Teacher(s)
prof. MUDr. Alexandra Šulcová, CSc. (lecturer)
prof. MUDr. Eva McCaskey Hadašová, CSc. (lecturer)
Ing. Pavel Musil (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
PharmDr. Hana Kolaříková (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
MUDr. Mgr. Karel Šlais, Ph.D. (lecturer)
MVDr. Dagmar Vršková, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
PharmDr. Lucia Zendulková Zahradníková, Ph.D. (lecturer)
Renata Bláblová (assistant)
Guaranteed by
prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Alexandra Šulcová, CSc.
Timetable
Mon 22. 9. to Fri 28. 11. Tue 13:00–15:30 P31 Posluchárna A. I. Bláhy
Prerequisites (in Czech)
VLFA0621c Pharmacology I - p && VSAJ0222 English 1 II -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
From the course on pharmacology students are expected to obtain: a) from lectures and seminars: a clarification of integration in the field of biomedical subjects such as chemistry, physiology, molecular biology, pathology and pathological physiology enabling them to understand why, what mechanism by, and what conditions on, drugs and their combinations may elicit therapeutic, adverse, and toxic effects. They will acquire an orientation in drug classes according to their main therapeutic indications with an attention paid to common drug-drug interactions, too. Information on drug development process, rules of preclinical and clinical drug testing will also be given. b) from practicals: a training in practical skills in "pharmacological thinking" in cases of need to make a choice of drug, dosing regimen, rout and techniques of administration, and an elimination of adverse interactions with drugs simultaneously given.
Syllabus
  • (22. 9. 2008) Pharmacology of hypothalamus and hypophysis functioning. Drugs indicated in disorders of skeletal homeostasis.
  • (29. 9. 2008) Antihypertensives. Diuretics, antiadrenergics, vasodilators, combinative pharmacotherapy.
  • (6. 10.2008) Anti-anginal agents (nitrites, beta-adrenergic blockers, calcium entry blockers). Lipid lowering agents.
  • (13. 10. 2008) Pharmacotherapy of heart failure. Inotropic drugs (digitalis, amrinone, dobutamine). Pharmacotherapy of cardiac arrythmias. I.A - affecting membrane functions, quinidine-like effects; I.B - affecting mebrane functions with anesthetic effects; I.C - lorcainide, flecainide, propafenone; II. - beta-blockers; III. - increasing APD; IV. - calcium channel antagonists.
  • (20.10.2008) Introduction to psychopharmacology. Neurotransmitter mechanisms and specific neurotransmitter systems.
  • (27.10.2008) Antipsychotics, treatment of psychosis, adverse effects. Drugs for affective (mood) disorders, Ist - III. (IV.)rd generations of antidepressants, anti-manic drugs.
  • (3.11. 2008) Nootropics. Anti-Parkinson pharmacotherapy, (dopaminergic drugs, central anticholinergic drugs). Drugs used in Alzheimer`s disease and other states of dementia.
  • (10. 11. 2008) Drug addiction, mechanisms, treatment and prevention.
  • (17. 11.2008) "State Holiday"
  • (24.11. 2008) Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.
Literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
  • ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993, 97 s. ISBN 80-210-0640-4. info
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
  • RANG, H. P. Rang and Dale's pharmacology. 6th ed. [S.l.]: Churchill Livingstone, 2007, xiii, 829. ISBN 9780443069116. info
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
  • Lippincott's Illustrated Reviews : Pharmacology : Special Millennium Update Autor: Mary Julia Mycek M.J. Richard A. HarveyR.A., Champe P.C. 2000. ISBN: 0781724139
Assessment methods
During the studying the student has to prove active knowledge of pharmacology acquired to get the credit. The student has to pass the prescription test and the final written exam - multiple-choice test.
Syllabus of questions for exam on Pharmacology

EXAMPLES OF QUESTIONS DEALING WITH DRUG PRESCRIPTION:

 Prescribe: Liquid powder against itching Narrow-spectrum penicillin (ready-made) Prescribe: Iodine solution in alcohol for wound dressing Aminoglycoside preparation (ready-made) Prescribe: Local anaesthetic for topical application on mucosal surface in ORL Oral analgesic preparation containing paracetamol (ready-made) Prescribe: Solution of diluted hydrogen peroxide Spasmolytic drug (ready-made) Prescribe: Dusting powder (without the active component) Non-barbiturate hypnotic drug (ready-made) Prescribe: Disinfectant eye drops with adstringent effect Drug for treatment of hypertension (ready-made) Prescribe: Jarisch solution for the foments Antirheumatic agent (ready-made) Prescribe: Local anaesthetic for corneal anaesthesia Antiemetic drug (ready-made) Prescribe: I. v. infusion of 5% glucose solution – 1000 ml Antitussive agent (ready-made) Prescribe: Codeine in drops (p.o.) Ointment with corticosteroid (ready-made) Prescribe: Expectorant with bronchodilator component Chemotherapeutic preparation against urinary infections (ready-made) Prescribe: Solution of diluted hydrogen peroxide Ointment with corticosteroid (ready-made) Prescribe: Disinfectant eye drops with adstringent effect Anti-inflamatory oral preparation (ready-made) Prescribe: A cough suppressant (opioid derivate) in capsules Proton pump inhibitor for treatment of peptic ulcer (ready-made) Prescribe: Morphine for oral administration Non-salicylate antipyretic preparation (ready-made) Prescribe: Ant-tussive/expectorant mixture Short-acting benzodiazepine hypnotic (ready-made) Prescribe: Oral drops with atropine Antibiotic ointment (ready-made) Prescribe: Salicylic acid ointment (3%) Cardiac glycoside in injections (ready-made)

EXAMPLES OF QUESTIONS ON GENERAL PHARMACOLOGICAL PRINCIPLES:

 Abnormal reaction to a drug Abnormal responses to drugs Absorption and distribution of drugs Adverse drug effects Antagonism in drug effects Basic pharmacokinetic processes Biopharmaceutical drug interactions Classification of receptors Competitive dualism (partial agonism) Dependence of drug effect on a route of administration Development of a new drug Drug addiction Drug allergy Drug delivery approaches Drug elimination half-life; rate constant Drug excretion Drug interactions with serum proteins Drug metabolism Drug-receptor interactions Effects of age on drug effects Enteral administration of drugs Enzyme induction and inhibition Excretion of drugs General principles of pharmacokinetics Kinetics of drug oral administration Non-specific mechanisms of drug effects Parenteral drug administration Parenteral routs of administration: characteristics; demands on injected solutions Pharmacodynamic drug interactions Pharmacogenetics Pharmacokinetic drug interactions Pharmacokinetic processes determining serum drug concentration Pharmacological mechanisms of drug effects Pharmacopoea Pharmadynamic drug interactions Possible mechanisms of synergistic drug effects Principles of the "Good Clinical Practice" Receptor-mediated drug effects Regulation of drug development Sites of drug binding in the organism Synergistic and antagonistic drug/drug interactions Synergism in drug effects Targets for drug action The management of poisoning Therapeutic ratio Type of drug effect changes after its repeated administration Types of drug doses

EXAMPLES OF QUESTIONS ON "DRUG CLASSES"

ACE-inhibitors Adrenomimetic agents Alpha-sympatolytics Aminoglycosides Antacids Antianginal agents Anti-anxiety drugs Antibiotics against gram-negative bacteria Anticoagulants Antidepressants Antidiabetics Antidysrhytmic drugs I. Antidysrhytmic drugs II., III., IV. Antiemetics Antiepileptic drugs Antifungal drugs Antihypertensive drugs Anti-inflammatory drugs Antipsychotics Anti-rheumatic drugs Antiviral drugs Beta-blockers Calcium channel blockers Cancer chemotherapetics Central nervous system stimulants Disinfectants and antiseptics Diuretics Drugs to treat anemia Folic acid and vitamin B12 Ganglionic blockers General anesthetics for IV (IM) administration Histamine H1-receptor blockers Hypno-sedatives Cholinergic drugs Inotropic drugs Lipid-lowering drugs Local anesthetics Neuromuscular blocking drugs Non-narcotic analgesics Non-steroidal anti-inflamatory agents Opioid analgesics Parasympathomimetics Pharmacotherapy of asthma bronchiale Pharmacotherapy of myocardial infarction Pharmacotherapy of Parkinson`s Pharmacotherapy of peptic ulcers Spasmolytic agents for systemic administration Sulphonamides Tetracyclines Vasodilators Vitamines


QUESTIONS ON "DETAILED KNOWLEDGE" FROM THE "15th WHO Model List of Essential Medicines, 2007" :

abacavir acetazolamide acetylcysteine acetylsalicylic acid aciclovir albendazole alcuronium allopurinol aluminium hydroxide amikacin amiloride amitriptyline amlodipine amodiaquine amoxicillin amphotericin B ampicillin anti - D immunoglobulin artemether artesunate ascorbic acid asparaginase atenolol atropine azathioprine azithromycin bacitracin BCG vaccine beclometasone benzathinpenicillin benzoyl peroxide benzylpenicillin betamethasone biperiden bleomycin bupivacaine caffeine capreomycin carbamazepine carbidopa cefazolin cefixime ceftazidime ceftriaxone chlorambucil chloramphenicol chlorhexidine chlorine base compound chloroquine chlorphenamine chlorpromazine ciclosporin cilastatin ciprofloxacin cisplatin clavulanic acid clindamycin clomifene clomipramine clotrimazole cloxacillin co-amoxicillin codeine cyanocobalamin cyclophosphamide cycloserine cytarabine dactinomycin dapsone daunorubicin deferoxamine dexamethasone dextran diazepam didanosine diethylcarbamazine digoxin diloxanide methionine dopamine doxorubicin doxycycline efavirenz eflornithine enalapril ephedrine adrenaline ergocalciferol ergometrine erythromycin estradiol ethambutol ethanol ethinylestradiol ethionamide ethosuximide etoposide ferrous salt fluconazole flucytosine fluorescein fluorouracil fluoxetine fluphenazine folic acid furosemide gentamicin gentian violet glibenclamide glucose glyceryl trinitrate griseofulvin haloperidol halothane heparin human intravenous immunoglobulin hydralazine hydrochlorothiazide hydrocortisone ibuprofen imipenem + cilastatin indinavir insulin iodine ipratropium bromide isoniazid isosorbide dinitrate ivermectin kanamycin ketamine lamivudine levamisole levodopa levonorgestrel levothyroxine lidocaine lithium lopinavir lumefantrine magnesium sulfate mannitol mebendazole medroxyprogesterone acetate mefloquine meglumine antimoniate melarsoprol mercaptopurine metformin methadone methotrexate methyldopa methylrosanilinium chloride (gentian violet) methylthioninium chloride (methylene blue) metoclopramide metronidazole miconazole mifepristone misoprostol morphine naloxone nelfinavir neomycin sulfate neostigmine nevirapine niclosamide nicotinamide nifedipine nifurtimox nitrofurantoin6 nitrous oxide1 norethisterone nystatin ofloxacin oxamniquine oxygen oxytocin p-aminosalicylic acid paracetamol paromomycin penicillamine pentamidine phenobarbital phenoxymethylpenicillin phenytoin phytomenadione pilocarpine polyvidone iodine praziquantel prednisolone primaquine procainamide procaine benzylpenicillin procarbazine proguanil promethazine propranolol propylthiouracil protamine sulfate pyrantel pyrazinamide pyridostigmine pyridoxine pyrimethamine quinine ranitidine retinol ribavirin riboflavin rifampicin ritonavir salbutamol salicylic acid saquinavir simvastatin sodium fluoride sodium hydrogen carbonate sodium nitroprusside sodium thiosulfate valproate spectinomycin spironolactone stavudine streptokinase streptomycin sulfadiazine sulfamethoxazole + trimethoprim (co-trimoxazol) sulfasalazine suramin suxamethonium tamoxifen tenofovir testosterone tetracaine tetracycline thiamine thiopental timolol triclabendazole trimethoprim tropicamide urea valproic acid vancomycin vecuronium verapamil vinblastine vincristine warfarin zidovudine zinc sulfate
***
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019.
  • Enrolment Statistics (Autumn 2008, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2008/VLFA0722p