VSPF0521p Pathological Physiology I - lectures

Faculty of Medicine
Autumn 2011
Extent and Intensity
2/0/0. 0 credit(s). Type of Completion: -.
Teacher(s)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Lydie Izakovičová Hollá, Ph.D. (lecturer)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Timetable
Wed 13:30–15:10 B22/116 aula
Prerequisites (in Czech)
VSFY0422p Physiology II - lecture && ( VSBC041p Biochemistry II -l || VSBC0422p Biochemistry II -l ) && VSAN0333p Anatomy III l && VSHE0322p Histology and embryology II -l && ( VSLT0221s Bas. Med. Terminol. II -s || VSLT011s Bas. Med. Terminology -l ) && VSET021 Medical Ethics I && ZC041 Handling chemical substances
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to teach students to be able to answer a sufficient number of pathophysiologically asked questions "why", especially focused on these themes:
Pathological Physiology as a science. Disease, health, normality. Descriptivism contra normativism.
Physiology of genes, regulation of gene activity.
Monogenic and multigenic diseases.
Shock syndrome.
Reactive oxygen species (ROS). Ionising radiation effects on cellular level.
Ionising radiation effects on tissue and organismal level.
Cardiovascular pathophysiology - systolic and diastolic function.
Cardiac failure.
Myocardial ischemia.
Hypertension.
Pathophysiology of the gas exchange in the lungs.
Pathophysiology of respiratory mechanics.
Chronic obstructive bronchopulmonary disease.
Restriction pulmonary diseases, respiratory failure.
Physiology of membrane transports.
Syllabus
  • 20/9 2011 Pathophysiology: an integrating medical speciality. Aetiology and pathogenesis of diseases.
  • Lecturer: Prof. Anna Vašků
  • 27/9 Interaction of cells and intercellular communication, basic principles of intracellular signalling. Reaction of the cell on damage and hypoxia. Cell death. Cytokines network. Chemokines.
  • Prof. Anna Vašků
  • 4/10 Inflammation. Acute phase reaction. Systemic reaction of organism on damage. Regeneration and reparation. Wound healing.
  • Prof. Anna Vašků
  • 11/10 Pathophysiology of malignant transformation.
  • Prof. Anna Vašků
  • 18/10 Hypertension. Remodelling of blood vessels. Diseases of peripheral blood vessels.
  • Prof. Anna Vašků
  • 25/10 Metabolism of myocardium, atherosclerosis, ischemic heart disease, myocardium infarction.
  • Prof. Lýdie Izakovičová Hollá
  • 1/11 Pressure and volume overload of heart; systolic and diastolic dysfunction, heart remodelling, heart failure.
  • Prof. Anna Vašků
  • 8/11 Stress, general adaptation syndrome.
  • Prof. Anna Vašků
  • 15/11 Pathophysiology of gas exchange in the lungs. Ventilation control.
  • Prof. Lýdie Izakovičová Hollá
  • 22/11 Lung diseases.
  • Prof. Izakovičová Hollá
  • 29/11 Pathophysiological aspects of renal functions.
  • Prof. Anna Vašků
  • 6/12 Acute and chronic renal failure.
  • Prof. Lýdie Izakovičová Hollá
  • 13/12 Pathophysiology of water and electrolytes. Tonicity and volume disturbances.
  • Prof. Anna Vašků
  • 3/1 2012 Pathophysiological aspects of metabolism of calcium and phosphates, bone pathophysiology.
  • Prof. Vašků
Literature
  • NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. ISBN 80-246-0051-X. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, 379 s. ISBN 9788024606750. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
  • PORTH, Carol. Pathophysiology : concepts of altered health states. 5th ed. Philadelphia: Lippincott-Raven, 1998, xxviii, 14. ISBN 0397554133. info
Teaching methods
lecture
Assessment methods
The attendance of lectures and only one absence on practicals per semester are necessary for succesfull accomplishment of the subject. Continous control of knowlledge in practicals is fully in powers of teachers (assays, tests...). Elaborated proceedings of practicals will be put to teachers for credit.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017.
  • Enrolment Statistics (Autumn 2011, recent)
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