VSPF0521c Pathological physiology I - practice

Faculty of Medicine
Autumn 2013
Extent and Intensity
0/3/0. 4 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. MUDr. Julie Dobrovolná, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
prof. MUDr. Kateřina Kaňková, Ph.D. (seminar tutor)
Mgr. Andrea Knight, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. RNDr. Michal Masařík, Ph.D. (seminar tutor)
Mgr. Lukáš Pácal, Ph.D. (seminar tutor)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (seminar tutor)
Dipl. Ing. Martin Piskáček, Dr. rer. nat. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
VSPF0521c/01: Fri 7:30–10:00 A18/106
VSPF0521c/02: Fri 7:30–10:00 A18/106
VSPF0521c/03: Fri 10:20–12:50 A18/106
VSPF0521c/04: Fri 10:20–12:50 A18/106
VSPF0521c/05: Mon 7:30–10:00 A18/106
VSPF0521c/06: Mon 7:30–10:00 A18/106
VSPF0521c/07: Mon 10:20–12:50 A18/106
VSPF0521c/08: Mon 10:20–12:50 A18/106
VSPF0521c/09: Tue 7:30–10:00 A18/106, J. Máchal
VSPF0521c/10: Tue 7:30–10:00 A18/106, J. Máchal
VSPF0521c/11: Tue 10:20–12:50 A18/106, J. Máchal
VSPF0521c/12: Tue 10:20–12:50 A18/106, J. Máchal
VSPF0521c/13: Thu 7:30–10:00 A18/106
VSPF0521c/14: Thu 7:30–10:00 A18/106
VSPF0521c/15: Thu 10:20–12:50 A18/106
VSPF0521c/16: Thu 10:20–12:50 A18/106
VSPF0521c/17: Wed 7:30–10:00 A18/106
VSPF0521c/18: Wed 7:30–10:00 A18/106
VSPF0521c/19: Wed 10:20–12:50 A18/106
VSPF0521c/20: Wed 10:20–12:50 A18/106
VSPF0521c/30: No timetable has been entered into IS.
VSPF0521c/31: No timetable has been entered into IS.
VSPF0521c/32: No timetable has been entered into IS.
VSPF0521c/33: No timetable has been entered into IS.
VSPF0521c/34: No timetable has been entered into IS.
VSPF0521c/35: No timetable has been entered into IS.
Prerequisites
VSFY0422p Physiology II - lecture && ( VSBC041p Biochemistry II -l || VSBC0422p Biochemistry II -l ) && VSAN0333p Anatomy III -l && VSHE0322p Histology and Embryology II -l && ( VSLT0221s Bas. Med. Terminol. II -s || VSLT011s Bas. Med. Terminology -l ) && VSET021 Medical Ethics I && ZC041 Handling chemical substances
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The student will be trained for assuming these knowledge and skills:
Principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals - explorative laparotomy
Pathophysiology of blood and bone marrow disorders, haematological findings in selected blood disorders
Statistical analysis of experiments (introduction)
Exp. induced acute radiation syndrome in lab. animal – haematological consequences
Essential hypertension, resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise
Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry and hyperoxic test
Secondary hypertension, exp. induced renal ischemia – quantification of renal rennin expression
Conductive disorders, demonstration of selected types of arrhythmias
ECG monitoring of exp. induced arrhythmias in lab. animal
Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion
Exp. induced renal failure - peritoneal dialysis in lab. animal
Syllabus
  • 19.9 20.9 Introduction, health & safety in the lab, principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals & explorative laparotomy [dr. Michal Jurajda, PhD., dr. Michal Masařík, PhD.] 26.9 27.9 Statistical analysis of experiments (introduction) [dr. Michal Jurajda, PhD., Mgr.Lukáš Pácal, PhD.] 3.10 4.10 Principles of ECG analysis, demonstration of selected pathological ECG patterns [dr. Jan Máchal, dr. Monika Pávková-Goldbergová, PhD, PhD.] 10.10 11.10 Conductive disorders (seminar), ECG monitoring of exp. induced arrhythmias in lab. animal [dr. Monika Pávková-Goldbergová, PhD., dr. Jan Máchal] 17.10 18.10 Principles and demonstration of peripheral blood flow examination using ultrasonography [dr. Jan Máchal, dr. Michal Jurajda, PhD.] 24.10 25.10 Cell cycle, oncogenes and supressor genes, cancer development. (seminar) [ing. Martin Piskáček, PhD., Mgr. Sabina Ševčíková, PhD.] 31.10 1.11 Exp. induced acute radiation syndrome in lab. animal – haematological consequences [dr. Michal Jurajda, PhD., ing. Martin Piskáček, PhD.] 7.11 8.11 Secondary hypertension (seminar), exp. induced renal ischemia (part 1) [dr. Monika Pávková-Goldbergová, PhD., Mgr.Lukáš Pácal, PhD.] 14.11 15.11 Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry. [dr. Julie Bienertová-Vašků PhD., dr. Michal Jurajda, PhD.] 21.11 22.11 Essential hypertension (seminar), resting and ambulatory blood pressure (and heart rate) measurements, postural changes, effect of isometric and aerobic exercise [dr. Jan Máchal, dr. Julie Bienertová-Vašků, PhD.] 28.11 29.11 Exp. induced renal ischemia – detection of renal renin expression (part 2) [dr. Michal Masařík, PhD., dr. Monika Pávková-Goldbergová, PhD.] 5.12 6.12 Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion [Mgr. Lukáš Pácal, PhD., dr. Michal Jurajda, PhD.] 12.12 13.12 Exp. induced renal failure - peritoneal dialysis in lab. animal [dr. Michal Masařík, PhD., Mgr. Lukáš Pácal, PhD.] 19.12 20.12 Acidbase balance (seminar), tests, credits [dr. Julie Bienertová-Vašků PhD., dr. Michal Jurajda, PhD.] Teachers: Po – As. MUDr. Michal Jurajda PhD.
  • Út – Doc. MUDr. Kateřina Kaňková, PhD.
  • St – As. MUDr. Jan Máchal, as. MUDr. Monika Goldbergová-Pávková, PhD.
  • Čt – Prof. MUDr. Anna Vašků, CSc., as. MUDr. Julie Bienertová-Vašků, PhD.
  • Pá – As. Mgr. Lukáš Pácal. PhD., as. RNDr. Michal Masařík, PhD.
Literature
Teaching methods
practical exercises in labs, discussion to the given topics, video with comments
Assessment methods
Practicals are compulsory. The only permited reason for not attending is a student's sick leave. Student can - with tutor's approval - substitute the particular practical in a given week with another group in case he/she has a justifiable reason for it. Student's participation in the practicals throughout the term is certified by a credit. Students can be given written tests or individual home work by tutor's throughout the term. Students have to be wearing lab coats during the practicals.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Studenti opakující 3. ročník nemusejí znovu absolvovat praktika, budou jim uznány zápočty, ke zkoušce mohou přijít v nejbližším zkouškovém období.
The course is also listed under the following terms Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017.
  • Enrolment Statistics (Autumn 2013, recent)
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