LF:aVLBC0321s Biochemistry I - sem.

aVLBC0321s Biochemistry I - seminar

Faculty of Medicine
Autumn 2017

Extent and Intensity

0/2/0. 4 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine

Timetable of Seminar Groups

aVLBC0321s/30: Tue 10:30–12:10 A16/215, H. Paulová
aVLBC0321s/31: Mon 14:00–15:40 A16/215, J. Dostál
aVLBC0321s/32: Mon 14:00–15:40 A16/215, J. Dostál
aVLBC0321s/33: Mon 16:00–17:40 A16/215, E. Táborská
aVLBC0321s/34: Tue 10:30–12:10 A16/215, H. Paulová
aVLBC0321s/35: Tue 16:40–18:20 A16/215, J. Tomandl
aVLBC0321s/36: Tue 16:40–18:20 A16/215, J. Tomandl
aVLBC0321s/37: Mon 16:00–17:40 A16/215, E. Táborská
aVLBC0321s/38: Tue 10:30–12:10 A16/215, J. Slanina

Prerequisites (in Czech)

aVLBI0222c Biology II - pract. && aVLBF011c Biophysics - pract.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

Seminars and exercises have a common content and serve for active practice of the subject matter in Biochemistry I. The aim of the course is to obtain knowledge on essential metabolic processes on the cellular level. Understanding of these proceses is a base for comprihension of metabolism on the tissue and organ level. In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemichal pathways in cells.

Learning outcomes

In the end of the course will students understand the meaning of basic chemical terms (pH, osmolality, electrolyte, buffer, etc.) and apply this knowledge when describing the properties of body fluids.
Describes the role of macro- and microbiogenic elements in the organism
Discusses the properties and function of enzymes
Describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
Understands the principles of energy production, utilization and deposition at the cellular level.
Explains the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
Describes protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understands the relationship between protein structure and function.
Explains the function of hemoglobin in oxygen transport and maintaining acid-base balance.
Discusses the principles of some diseases at the molecular level.

Syllabus

Chemical composition of human body.
Water, electrolytes, osmotic pressure, osmolality. pH, buffers. Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types. Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition. Coenzymes, their relationship to vitamins. Membrane structure and assembly. Transport across membranes. Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance. Important reactions in amino acid catabolism. Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols. Metabolism of phospholipids. Biosynthesis of eicosanoids. Peroxidation of lipids. The citric acid cycle. The respiratory chain and oxidative phosphorylation. Replication, transcription, proteosynthesis.

Literature

required literature

Seminar texts available in Information system

Teaching methods

Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.

Assessment methods

Full attendance in seminars is the principal condition. If any absence, it must be apologized through Department of Study Affairs up to five days. If apology is recorded in Information System, then student is allowed to make up the absence according to teacher's instructions. Four revision tests are written in seminars, semestral limit for credit is 42. If the semestral limit is not fulfilled, student must write the Credit test (limit 14/30). All absences must be made up before writing the credit test. One repetition of the Credit test is approved.

Language of instruction

English

Further Comments

The course is taught annually.

Listed among pre-requisites of other courses

The course is also listed under the following terms Autumn 2016, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023, autumn 2024.

Enrolment Statistics (Autumn 2017, recent)
Permalink: https://is.muni.cz/course/med/autumn2017/aVLBC0321s

LF:aVLBC0321s Biochemistry I - sem. - Course Information

aVLBC0321s Biochemistry I - seminar

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