LF:ZLBC0321p Biochemistry I - lecture - Course Information
ZLBC0321p Biochemisty I - lecture
Faculty of Medicineautumn 2021
- Extent and Intensity
- 2/0/0. 1 credit(s). Type of Completion: z (credit).
- Teacher(s)
- doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant) - Guaranteed by
- doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine - Timetable
- Tue 14. 9. to Tue 21. 9. Tue 14:00–15:40 B22/116 aula, Tue 12. 10. to Tue 14. 12. Tue 14:00–15:40 B22/116 aula; and Tue 5. 10. 14:00–15:40 B11/234
- Prerequisites (in Czech)
- ZLLC011p Med Chem, Dent Mat - lect && ZLBF0222p Med.Physics and Inf. II - lect && ZLBI0222p Biology II-lect.
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Dentistry (programme LF, M-ZL) (2)
- Course objectives
- The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
- Learning outcomes
- In the end of the course will students understand the properties and function of enzymes
Describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
Understand the principles of energy production, utilization and deposition at the cellular level.
Explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
Describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understand the relationship between protein structure and function.
Explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
Discusses the principles of some diseases at the molecular level. - Syllabus
- Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic activity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. The citric acid cycle. Synthesis of haem. Mitochondria. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
- Literature
- required literature
- LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
- LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, Strana 275. ISBN 9788024647494. info
- Teaching methods
- Přednášky.
- Assessment methods
- Students pass to continuing education in the following semester without any duty of knowledge checking in this semester.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course is taught annually.
Information on the extent and intensity of the course: 30. - Listed among pre-requisites of other courses
- ZLIM051c Immunology in Dentistry- practice
(ZLBC0221p || ZLBC0321p) && ZLFY0422c && ZLFY0422s && ZLLM0421c - ZLIM051p Immunology in Dentistry - lecture
(ZLBC0221p || ZLBC0321p) && ZLFY0422c && ZLFY0422s && ZLLM0421c - ZLLM0522c Medical Oral Microbiology II - practice
ZLLM0421c && (ZLBC0221p || ZLBC0321p) && (ZLET021p || ZLET011p) && (ZLLT0222s || ZLLT011s) - ZLLM0522p Medical Oral Microbiology II - lecture
ZLLM0421c && (ZLBC0221p || ZLBC0321p) && (ZLET021p || ZLET011p) && (ZLLT0222s || ZLLT011s)
- ZLIM051c Immunology in Dentistry- practice
- Enrolment Statistics (autumn 2021, recent)
- Permalink: https://is.muni.cz/course/med/autumn2021/ZLBC0321p