EMBC0321s Biochemistry I - seminar

Faculty of Medicine
autumn 2022
Extent and Intensity
0/4/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
Mgr. Jana Gregorová, Ph.D. (seminar tutor)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 13. 9. 12:00–13:40 A16/215, Fri 16. 9. 10:00–11:40 A16/213, Tue 20. 9. 12:00–13:40 A16/215, Fri 23. 9. 10:00–11:40 A16/213, Tue 27. 9. 12:00–13:40 A16/215, Fri 30. 9. 10:00–11:40 A16/213, Tue 4. 10. 12:00–13:40 A16/215, Fri 7. 10. 10:00–11:40 A16/213, Tue 11. 10. 12:00–13:40 A16/215, Fri 14. 10. 10:00–11:40 A16/213, Tue 18. 10. 12:00–13:40 A16/215, Fri 21. 10. 10:00–11:40 A16/213, Tue 25. 10. 12:00–13:40 A16/215, Tue 1. 11. 12:00–13:40 A16/215, Fri 4. 11. 10:00–11:40 A16/213, Tue 8. 11. 12:00–13:40 A16/215, Fri 11. 11. 10:00–11:40 A16/213, Tue 15. 11. 12:00–13:40 A16/215, Fri 18. 11. 10:00–11:40 A16/213, Tue 22. 11. 12:00–13:40 A16/215, Fri 25. 11. 10:00–11:40 A16/213, Tue 29. 11. 12:00–13:40 A16/215, Fri 2. 12. 10:00–11:40 A16/213, Tue 6. 12. 12:00–13:40 A16/215, Fri 9. 12. 10:00–11:40 A16/213
Prerequisites (in Czech)
EMLC0111p Medical Chemistry - lecture && EMBI0222s Biologie II - seminář || EMBI0222p Biologie II - přednáška
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are used for active practice of the subject in the subject EMBC0111p Biochemistry I - lecture. The aim of the course EMBC0111s Biochemistry I - seminar is to gain knowledge about the basic metabolic processes and pathways taking place at the cellular level. Understanding these processes is the basis for understanding metabolism at the tissue and organ level, which is studied in the follow-up course Biochemistry II.
Learning outcomes
After completing the course the student will be able to:
- understand the properties and function of enzymes
- describe the basic catabolic and anabolic pathways of cellular metabolism of carbohydrates, lipids and proteins and their connections
- understand the principles of obtaining, using and storing energy at the cellular level
- describe the function of cell membranes and transport processes on the membrane
- describe the basic features of protein synthesis, starting with the processes of replication and transcription, translation and posttranslational modification
- understand the relationship between the structure and function of proteins
- describe the function of hemoglobin in transporting oxygen and maintaining acid-base balance
- discuss the principles of some diseases at the molecular level
Syllabus
  • Hemoglobin, structure, hemoglobin oxygen saturation, hemoglobin glycation, hemoglobinopathy.
  • Kinetics of enzyme reactions, enzyme quantification, optical test, rate of enzyme reaction, saturation curve, inhibitors, isoenzymes. Oxidoreduct cofactors, transfer cofactors.
  • Membrane transport, membrane structure.
  • Glucose metabolism, glycolysis, gluconeogenesis, glycogen.
  • Protein metabolism, transamination, deamination, ammonia detoxification.
  • Metabolism of selected amino acids.
  • Lipid metabolism, beta-oxidation of MK, ketone bodies, synthesis of MK, synthesis of lipids and cholesterol.
  • Lipid peroxidation. MK desaturation. Icosanoids.
  • Citrate cycle. Heme synthesis.
  • Respiratory chain, aerobic phosphorylation.
  • Replication, transcription, proteosynthesis.
Literature
    required literature
  • Studijní podklady dostupné v IS.
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
    recommended literature
  • LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
Teaching methods
Theoretical preparation and discussion on individual topics.
Assessment methods
Course-unit credit. Conditions for giving the course-unit credit (all conditions should be met):
  • Full attendance in lessons. All absences should be justified and made up.
  • At least 70% success rate from partial revision tests or 50% success rate in credit test, the resit credit test can be taken only once.
    The detailed conditions are posted in Information System (Study materials – Course-related instructions).
    • Language of instruction
    Czech
    Further comments (probably available only in Czech)
    Information on the extent and intensity of the course: 60.
    Listed among pre-requisites of other courses
    The course is also listed under the following terms autumn 2021, autumn 2023, autumn 2024.
    • Enrolment Statistics (autumn 2022, recent)
    • Permalink: https://is.muni.cz/course/med/autumn2022/EMBC0321s