BLLC0111p Medical Chemistry - lecture

Faculty of Medicine
autumn 2023
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
Mgr. Jan Víteček, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Marie Tomandlová, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Mon 18. 9. 13:00–14:50 B11/234, Mon 25. 9. 13:00–14:50 B11/234, Mon 2. 10. 13:00–14:50 B11/234, Mon 9. 10. 13:00–14:50 B11/234, Mon 16. 10. 13:00–14:50 B11/234, Mon 23. 10. 13:00–14:50 B11/234, Mon 30. 10. 13:00–14:50 B11/234, Mon 6. 11. 13:00–14:50 B11/234, Mon 13. 11. 13:00–14:50 B11/234, Mon 20. 11. 13:00–14:50 B11/234, Mon 27. 11. 13:00–14:50 B11/234, Mon 4. 12. 13:00–14:50 B11/234, Mon 11. 12. 13:00–14:50 B11/234, Mon 18. 12. 13:00–14:50 B11/234
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to explain the basic relationships of general chemistry and to acquaint students with the basic structures and properties of an-/organic compounds important in medicine, nutrition and toxicology.
Learning outcomes
After completing the course, the student will be able to:
  • understand the basics of general, inorganic and organic chemistry in the scope necessary for further study of biochemistry.
  • apply general physical-chemical laws to processes in living organisms.
  • describe the properties of the major biogenic elements and compounds of importance in medicine, nutrition, and toxicology.
  • describe and discuss the properties and reactions of organic and bioorganic compounds important for understanding biochemical processes.
    • Syllabus
    • Dispersion systems, diffusion, colligative properties, osmotic pressure. Colloidal solutions, dialysis. Surfactants.
    • Electrolyte solutions, ion activity, ionic strength. Proteolytic reactions: basic concepts and pH calculations, ion hydrolysis, polyhydric electrolytes, buffer systems.
    • Chemical thermodynamics, Gibbs energy, bioenergetics. Chemical kinetics.
    • Oxidation-reduction reactions, electrode potentials, relation to Gibbs energy change and equilibrium constant. Biochemically important redox systems. Precipitation reactions, solubility of salts.
    • Biologically important elements and their compounds.
    • Biologically important reactions and relationships between organic compounds (redox reactions, transamination, citrate cycle reactions, alcohols).
    • Biologically important heterocyclic compounds (cofactors, vitamins, synthetic drugs, alkaloids, drugs).
    • Structure and properties of monosaccharides. Oligosaccharides.
    • Homopolysaccharides and heteropolysaccharides. Glycosides.
    • Fatty acids, triacylglycerols, phospholipids, glycolipids.
    • Steroids. Steroid hormones. Calcioly. Eicosanoids.
    • Coded amino acids - polarity classification, pH dependence of structure. Biochemical transformations of amino acids. Uncoded amino acids.
    • Protein structure. Examples of globular, fibrillar and membrane proteins. Biologically active peptides. Glycoproteins, hemoproteins.
    • Nucleosides. Nucleotides. Nucleic acids.
    Literature
    Teaching methods
    Lecture.
    Assessment methods
    A written exam consisting of two parts:
  • PC-test
  • paper-based test
    • Language of instruction
    Czech
    Further comments (probably available only in Czech)
    Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů BLLC0111s a BLLC0111c.
    The course is taught annually.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    Teacher's information
    Information about the exam, including the assessment and the topics included in the exam, is available in the IS MUNI Study Materials - Organizational Instructions.
    The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2024.
    • Enrolment Statistics (autumn 2023, recent)
    • Permalink: https://is.muni.cz/course/med/autumn2023/BLLC0111p