aVLKB091 Clinical Biochemistry

Faculty of Medicine
autumn 2024
Extent and Intensity
0/2/0. 3 credit(s). Type of Completion: k (colloquium).
In-person direct teaching
Teacher(s)
MUDr. Lenka Gescheidtová, Ph.D. (lecturer)
MUDr. Michaela Jurčišinová (lecturer)
MUDr. Jan Kočica, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (lecturer)
MUDr. Ondřej Kyselák, Ph.D., EuSpLM (lecturer)
MUDr. Jan Novák, Ph.D. (lecturer)
MUDr. Lukáš Opatřil, Ph.D. (lecturer)
prof. MUDr. Vladimír Soška, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
Mgr. Ondřej Wiewiorka, Ph.D. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: MUDr. Michaela Králíková, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 15:00–17:50 A21/111
Prerequisites (in Czech)
aVLPF0622p Pathophysiology II - lecture || aZLPF0622p Pathophysiology II - lecture
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
To introduce students with - the factors affecting laboratory test results and their interpretation - principles of proper collection and processing of biological material - the evaluation of the validity of laboratory tests - laboratory diagnosis of selected diseases.
Learning outcomes
Student will be able to:
- purposefully indicate laboratory biochemical tests
- correctly interpret laboratory results
- evaluate laboratory tests with regard to their sensitivity and specificity, and predictive value
- use knowledge of the uncertainty of the evaluated parameter
- to focus on possible pre-analytical influences and interferences
Syllabus
  • Biochemical tests - variability and reliability of the result, specificity, sensitivity, validity, reference limits, uncertainty, ROC curves. Preanalytical influences on laboratory examination.
  • Diagnosis and monitoring of nutritional status. Principles of parenteral and enteral nutrition. Energy sources.
  • Energy expenditure, nitrogen balance. Oxygen, transport and oxygenation disorders. Load states, energy balance.
  • Disorders of lipid metabolism.
  • Biochemical markers in cardiology.
  • Management of water and mineral substances. Serum and urine osmolality.
  • Acid-base metabolism. Examination indications, interpretation of parameters.
  • Importance of determination of Na, K, Cl.
  • Biochemical diagnosis of kidney diseases, their monitoring. Functional tests. Urinary sediment. Hemodialysis.
  • Biochemical examination of the liver and bile ducts. Manifestations of damage, differential diagnosis of jaundice, cholestatic syndrome.
  • Biochemical examination of the gastrointestinal tract. Gastric secretions, resorption disorders and intestinal diseases, pancreatic function tests.
  • Disorders of glucose metabolism, diabetes mellitus.
  • Metabolism of essential trace elements.
  • Biochemical examination of the pituitary gland, thyroid gland and adrenal glands.
  • Calcium and phosphate metabolism. Markers of bone metabolism. Vitamin D.
  • Tumor markers.
  • Blood serum proteins. Acute phase reactants. Monoclonal gammopathy.
  • Biochemical and morphological examination of cerebrospinal fluid.
  • Inherited disorders of metabolism; congenital metabolic defects; newborn screening.
  • Peculiarities of laboratory investigation in childhood.
Literature
    required literature
  • Rajdl. D. a kol. Clinical biochemistry (e-book, formats: .pdf, .epub, .mobi) 1st ed. Prague, Karolinum Press, 2016, 426 s. ISBN: 978-80-246-3497-5. Download: https://karolinum.cz/en/books/rajdl-clinical-biochemistry-17096
    recommended literature
  • MARSHALL, William J. and S. K. BANGERT. Clinical chemistry. 6th ed. Edinburgh: Mosby, 2008, 416 s. ISBN 9780723434603. info
  • WALKER, Simon A. Lecture notes clinical biochemistry. 9th ed. Chichester, West Sussex: Wiley-Blackwell, 2013, xii, 290. ISBN 9781118272138. info
Teaching methods
Lectures, case reports.
Assessment methods
The colloquium – a written test.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/med/autumn2024/aVLKB091