VSBC041p Biochemistry II -lecture

Faculty of Medicine
Spring 2007
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
prof. MUDr. Vladimír Palyza, CSc. (lecturer)
doc. MUDr. Jaromír Sláma, CSc. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Jaroslava Tallová, CSc. (lecturer)
Lenka Nerudová (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 9:30–10:20 P31 Posluchárna A. I. Bláhy
Prerequisites (in Czech)
VSLC011p Med.Chem.- lecture && VSBI0222p Biology II - lecture && ( VSBF011p Biophysics || VLBF011p Biophysics-lect. || STBF011p Biophysics ) && VSBC0221s Biochemistry I-sem. && VSFY0321c Physiology I -practice && VSFY0321s Physiology I - sem.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Syllabus
  • Digestion and absorption of lipids. Blood plasma lipids and the major groups of lipoproteins. Metabolic fate of chylomicrons and VLDL, the metabolism of HDL. The biosynthesis of steroid hormones. The synthesis and hydroxylation of calciol. The integration of intermediary metabolism at the tissue and organ level. The metabolic functions of the liver. Catabolism of haemoglobin, bilirubin metabolism. Metabolism of iron. Biotransformation of xenobiotics. Control of metabolism. Mechanism of hormone and neurotransmitter action. Types of cell membrane receptors, intracellular effects of ligand binding; intracellular receptors. Nerve cells. Neurosecretion. The biosynthesis and inactivation of neurotransmitters, neurotransmission across synapses. Cholinergic, adrenergic, and (inhibitory) gabaergic receptors. Body water, the movement of water between ECF and ICF, water excretion. Ionic composition of blood plasma, gradients of Na+ and K+ across cell membranes. Osmolality of ECF, regulation of the ECF osmolality and volume, fluid and electrolyte balance. Transport of O2 and CO2. Metabolic pathways producing/consumpting H+ ions. Buffer bases of blood, blood plasma (concentrations of components), ICF, the parameters of acid-base status. The role of the lung, the kidney, and the liver in maintaining acid-base balance. Normal renal functions. Glomerular filtration. Tubular resorption and secretion. The major proteins of blood plasma. The blood-coagulation cascade, inhibition of clotting. Fibrinogen, fibrin, fibrinolysis. Blood cells. The specific immune response. Soluble and cell free antigens, immunoglobulin structures. Circulating immune complexes, secondary reactions. The extracellular matrix. Synthesis and post-translational modifications of collagen, intermolecular crosslinks in collagen and elastin, proteoglycans. Calcification of bone, regulation. Biochemical markers of bone resorption and formation.
Literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny (I. a II. díl). 1st ed. Praha: Karolinum, 2004, 561 pp. ISBN 80-246-0851-0. info
  • MURRAY, R.K. and D.K. GRANNER. Harperova biochemie. 3. v ČR. Jinočany: H & H, 2001, 872 pp. ISBN 80-7319-003-6. info
  • HOLEČEK, Milan. Regulace metabolizmu cukrů, tuků, bílkovin a aminokyselin. 1st ed. Praha: Grada Publishing, 2006, 286 pp. učebnice. ISBN 80-247-1562-7. info
  • Biochemistry :a concise text for medical students. Edited by D. K. Apps. 5th ed. London: Bailliere Tindall, 1992, vii, 448 s. ISBN 0-7020-1444-3. info
  • MURRAY, R. K., D. K. GRANNER and V. W. RODWELL. Harper's Illustrated Biochemistry. 27th ed. New York: Lange, 2006, 692 pp. textbook. ISBN 0-07-147885-x. info
  • CHAMPE, P. C., R. A. HARVEY and D. R. FERRIER. Lippincott's Illustrated Reviews: Biochemistry. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2005, 534 pp. textbook. ISBN 0-7817-2265-9. info
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Biochemie I.
Listed among pre-requisites of other courses
Teacher's information
http://www.med.muni.cz/toCP1250.cs/biochem/vyuka.html
The course is also listed under the following terms Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017.
  • Enrolment Statistics (Spring 2007, recent)
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