LF:VLFA0621p Pharmacology - lect. - Course Information

VLFA0621p Pharmacology - lectures

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: -.

Teacher(s)

doc. MUDr. Regina Demlová, Ph.D. (lecturer)
prof. MUDr. Alexandra Šulcová, CSc. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
MUDr. Alena Máchalová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Marianna Brabencová (lecturer)
Dr. Vincenzo Micale, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
MUDr. Mgr. Karel Šlais, Ph.D. (lecturer)
MUDr. Jana Unar Vinklerová, Ph.D., MBA (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
Anas Arab, Ph.D. (seminar tutor)
Mgr. Irena Babilonová (seminar tutor)
MVDr. Zuzana Babinská, Ph.D. (seminar tutor)
MVDr. Eva Dražanová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
Gabriela Přibyl Dovrtělová, Ph.D. (seminar tutor)
PharmDr. Irena Sehnalová, Ph.D. (seminar tutor)
Mgr. Tibor Štark, Ph.D. (seminar tutor)
PharmDr. Miroslav Turjap, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Nithyananda Thorenoor, Ph.D. (assistant)
Mgr. Hana Kostková (alternate examiner)
PharmDr. Lenka Součková, Ph.D. (alternate examiner)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable

Tue 13:50–15:30 B11/114

Prerequisites (in Czech)

VSPF0521c Pathophysiol. I - practice. && VSPA0521c Pathology - practicals

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• General Medicine (eng.) (programme LF, M-VL)
• General Medicine (programme LF, M-VL)

Course objectives

At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Syllabus

• LECTURES

• Spring semester 2015 (Friday 1:30-4:00 p.m.)

• Dept. of Pharmacology, A19, Room 231
• 1^st week, February, 27
• The scope and historical development of modern pharmacology. Basic pharmacological terms, definitions. Physiological and pathological factors influencing drug effects. Adverse drug effects.
• 2^nd week, March, 6
• Drug Life-Cycle. Innovative and generic products. Biosimilars. Orphan drugs.
• 3^rd week, March, 13
• Drug delivery approaches, routes of administration, prolonged release preparations. The management of poisoning.
• 4^th week, March, 20
• Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration. Basic principles of Pharmacogenetics.
• 5^th week, March, 27
• Mechanisms of drug action, non-specific, specific. Receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors
• 6^th week, April, 3
• Drug interactions. Assessment of the seriousness of drug interactions.
• 7^th week, April, 10
• Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiarities. Specificities of pharmacotherapy in the elderly.
• 8^th week, April, 17
• Pre-clinical and clinical drug development. Drug registration guidance. Regulation and guidelines for "Good Clinical Practice".
• 9^th week, April, 24
• Principles of pharmacovigilance, duties of physicians and pharmaceutical companies, general rules in drug promotion.
• 10^th week, May, 1
• Basic principles of pharmacoeconomics, types of pharmacoeconomic analyses and their relevant use in clinical practice.

Literature

required literature
• LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
• http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
• http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html

recommended literature
• Rang & Dale's pharmacology 7th Edition:with student consult online access. Edited by H. P. Rang. : Churchill Livingstone, 2012.
• DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
• https://is.muni.cz/auth/el/1411/jaro2009/VLFA0621c/um/Practicals_in_Pharmacology_ENGL.pdf?fakulta=1411;obdobi=4504;kod=VLFA0621c
• MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 1. vyd. Praha: Grada, 2007, 379 s. ISBN 9788024713564. info

not specified
• Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
• Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

• Enrolment Statistics (Spring 2015, recent)
  
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