aVLBI0222p Biology II - lecture

Faculty of Medicine
Spring 2018
Extent and Intensity
1/0/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
RNDr. Mário Špírek, PhD. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
Mgr. Kateřina Vopěnková, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (seminar tutor)
Mgr. Kateřina Straková, Ph.D. (seminar tutor)
Jana Růžičková (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Cetkovská, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. to Fri 18. 5. Wed 13:05–13:55 B11/334
Prerequisites
aVLBI0121c Biology I - pract. && aVLBI0121s Biology I - seminar
Knowledge of high-school biology and all previous lectures and practical classes of the subject are prerequisities for studying the course. Expected knowledge for each lecture is specified in the course syllabus. Literature recomended to study before each lecture is detailed in the interactive syllabus of the course.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- understanding the mechanisms of cancer development
- understanding the complex taking place during human embryonic development
- acquaintance with the basics of genomics, gene therapy and tissue engineering in current medicine
Learning outcomes
After completing the course the student will be able to:
- explain the nature of cancers with regard to deregulation of cell division, DNA repair and cell death
- explain the effects of some therapies with emphasis on modern medicine (molecular therapies of cancer)
- explain the elementary processes taking place during development of a human body
- express the basic coherence between malfunction in these processes and developmental defects
- explain the basic principles of current methods used in gene therapy and cell therapies
- understand the significance of the human microbiome composition
- be knowledgeable in basic modern approaches to studying various diseases and to personalised medicine (genomics, bioinformatics)
Syllabus
  • DNA damage and repair – from molecular mechanisms to clinical significance
  • Introduction to cancer biology
  • Oncogenes and oncoviruses in cancer transformation
  • Tumour suppressor genes and their significance for diagnostics and therapy
  • Paradigm of cancer stem cells and implications for anti-cancer therapies
  • Gene therapy – targets and strategies of molecular therapies
  • Stem cells and tissue engineering – prospects of regenerative medicine
  • From a single cell to human I – introduction to developmental biology
  • From a single cell to human II – molecular basis of mammalian development in health and disease
  • Human genome, genomics and bioinformatics in current biomedicine
  • Human microbiome
  • Modern approaches in studying macromolecules and their use in current biomedicine
Literature
    required literature
  • ALBERTS, Bruce. Essential cell biology. 4th edition. New York, N.Y.: Garland Science, 2014, xxiii, 726. ISBN 9780815344551. info
  • Medical genetics at a glance. Edited by D. J. Pritchard - Bruce R. Korf. 3rd ed. Chichester, England: Wiley-Blackwell, 2013, 1 online r. ISBN 9781118689028. info
Teaching methods
lecture every week
Assessment methods
Lecture attendance is optional. The course of Biology II builds on knowledge gained from Biology I, and is completed with a written examination test taken on computers. The test contains questions based on the topics discussed in the lectures, seminars and practices of both semesters. The students are expected to be able to autonomously solve assigned problems and to derive the solutions using their own thinking – based on the theory discussed during both semesters and supplemented by the recommended reading. The test contains 60 questions in total; at least 30 points are needed to pass.
Language of instruction
English
Follow-Up Courses
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses

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Teacher's information
https://is.muni.cz/auth/el/1411/jaro2018/aVLBI0222p/index.qwarp
The course is also listed under the following terms Spring 2016, Spring 2017, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2018, recent)
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