LF:aVLBC0321p Biochemistry I - lecture - Course Information
aVLBC0321p Biochemistry I - lecture
Faculty of Medicineautumn 2024
- Extent and Intensity
- 3/0/0. 3 credit(s). Type of Completion: z (credit).
In-person direct teaching - Teacher(s)
- doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant) - Guaranteed by
- doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine - Timetable
- Mon 10:00–12:50 B11/334
- Prerequisites (in Czech)
- aVLBI0222p Medical Biology II - lect. && aVLBF011p Biophysics -lect.
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- General Medicine (programme LF, M-GM)
- General Medicine (eng.) (programme LF, M-VL)
- Course objectives
- The aim of the course is to introduce students to the basic metabolic pathways and processes occurring at the cellular level in the human organism.
- Learning outcomes
- Upon completion of the course, student will be able to:
- understand the meaning of basic chemical concepts and apply them in describing biochemical processes in an organism.
- discuss the properties and functions of enzymes.
- describe the basic catabolic and anabolic pathways of cellular metabolism of carbohydrates, lipids, and proteins.
- characterize the principles of energy acquisition, utilization, and storage in the cell.
- explain protein synthesis, beginning with the processes of replication and transcription, including posttranslational modifications.
- understand the relationship between the structure and function of proteins, e.g. haemoglobin, collagen, elastin.
- characterize the causes of some diseases at the molecular level. - Syllabus
- Electrolytes, ion activity. Weak acids/bases. Buffers. Bioenergetics, Gibbs energy, high-energy compounds. Redox reaction.
- Enzymes. Characteristic features of biocatalysis. Cofactors.
- Metabolism of nutrients. Citrate cycle. Respiratory chain. Oxidative phosphorylation.
- Carbohydrates in nutrition. Carbohydrate digestion. Basic features of glucose metabolism. Glucose transport into cells. Glycolysis. Gluconeogenesis.
- Glycogen. Metabolism of fructose, galactose, lactose. The pentose phosphate pathway. Glycosaminoglycans, proteoglycans.
- Lipids and fatty acids. Surfactants. Lipophilic vitamins. Lipids in nutrition. Lipid digestion. Fatty acid metabolism. PUFA synthesis. Metabolism of ketone bodies.
- Metabolism of triacylglycerols, glycerophospholipids, sphingolipids. Lipid peroxidation. Biosynthesis and importance of eicosanoids.
- Metabolism of cholesterol, bile acids. Biosynthesis of calciols.
- Amino acids. Peptides. Structure of proteins, myosin, collagen, immunoglobulins. Hemoglobin, myoglobin. Hemoglobinopathies.
- Digestion and intracellular degradation of proteins. General features in catabolism of amino acids. Ammonia metabolism and toxicity.
- Catabolism of amino acids, congenital disorders of amino acid metabolism. Synthesis of non-essential amino acids.
- Conversions of amino acids into low molecular weight products. Heme synthesis, porphyria.
- Metabolism of purine/pyrimidine nucleotides.
- Structure of DNA, RNA. Replication and corrections. Transcription and its regulation, post-transcriptional modifications.
- Protein synthesis. Folding, transport and sorting of proteins in the cell. Post-translational modification.
- Biosynthesis of collagen, elastin.
- Literature
- required literature
- RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY and P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
- Essentials of Medical Chemistry and Biochemistry (Ed. Dostál J.). Download: https://portal.med.muni.cz/article-623-essentials-of-medical-chemistry-and-biochemistry.html
- recommended literature
- LIEBERMAN, Michael and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
- VASUDEVAN, D. M., S. SREEKUMARI and Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016, xvi, 718. ISBN 9789385999741. info
- KOOLMAN, Jan and Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
- Teaching methods
- Lectures.
- Assessment methods
- Credit, no knowledge testing.
The course is followed in the 4th semester by Biochemistry II. The content of Biochemistry I is included in the Biochemistry II exam. - Language of instruction
- English
- Further comments (probably available only in Czech)
- The course is taught annually.
Information on the extent and intensity of the course: 45. - Listed among pre-requisites of other courses
- Enrolment Statistics (recent)
- Permalink: https://is.muni.cz/course/med/autumn2024/aVLBC0321p