aVLFA0822c Pharmacology II - practice

Faculty of Medicine
Spring 2018
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
aVLFA0721p Pharmacology I - lecture
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to acquiant the students with drugs from selected pharmacotherapeutic groups and to learn them how to use the drugs rationally with respect to their mode of action, indications and contraindications. Moreover, students will be shown, where to find relevant data on drugs and how to work with it.
Learning outcomes
At the end of the course student should be able to prescribe representatives of individual drug classes in the form of individually prepared pharmaceutical preparation and bulk drugs. The student should be familiar with pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions.
Syllabus

  • VLFA08222c Pharmacology II- practicals

    Spring semester

  • Week 1
  • Introduction, instructions. Distribution of co-talks.
  • ANALGESICS.
  • Opioid analgesics. Pharmacotherapy of pain. Opioid addiction therapy. Prescription and practical use of analgesic preparations.
  • Week 2
  • NON-STEROIDAL ANTIINFLAMMATORY DRUGS, DRUGS USED IN GOUT, ANTIPYRETICS.
  • Mechanisms of action and classification of anti-inflammatory drugs. Drugs used in therapy of gout.
  • Getting ready for the next lesson: Central neurotransmitters and sites of drug effects in CNS. Basic psychical functions.
  • Week 3
  • ANTIDEPRESSANTS.
  • Classification and terminology of antidepressants. Review of their mechanisms of action, adverse effects, interactions.
  • Co-talks.
  • Week 4
  • THERAPY OF ANXIETY, HYPNOSEDATIVES.
  • Classification and terminology of psychotropics. Review of their mechanisms of action. Pharmacology of anxiolytics and hypnosedatives. Mechanism of action of benzodiazepines. Prescription of hypnosedatives and psychostimulants.
  • Co-talks.
  • Week 5
  • REVISING TEST I (Revision test with subsequent discussion) Lesson 1 – 4.
  • 5/CASE REPORTS I.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • Getting ready for the next lesson: Pathophysiology of cancer disease
  • Week 6
  • PHARMACOLOGY OF ANTICANCER DRUGS.
  • Classification, mechanisms of action, side effects.
  • Co-talks.
  • Getting ready for the next lesson: Structure of bacterial cell, basis of antimicrobial therapy.
  • Week 7
  • ANTIMICROBIAL AGENTS I.
  • Classification, mechanisms of action, combinations of antibiotics and chemotherapeutics.
  • Co-talks.
  • Week 8
  • ANTIMICROBIAL AGENTS II., THERAPY OF INFECTIOUS DIARRHEAS AND UROINFECTIONS.
  • Drugs for the treatment of intestinal and urinary infections.
  • Co-talks.
  • Week 9
  • REVISING TEST II (Overhead-test with subsequent discussion). Lessons 5 - 8.
  • CASE REPORTS II.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • Co-talks.
  • Getting ready for the next lesson: Autonomic nervous system – catecholamines, atropine. Muscle relaxants.
  • Week 10
  • GENERAL AND LOCAL ANAESTHETICS
  • Combined and balanced anaesthesia. Signs and stages of general anaesthesia. Inhaled and injected anaesthetics - classification and characteristics. Review of drugs used in premedication.
  • Co-talks.
  • Getting ready for the next lesson: : Revision of blood coagulation.
  • Week 11
  • ANTICOAGULANTS AND THROMBOLYTICS.
  • Fibrinolytics, haemostatics.
  • Co-talks.
  • Getting ready for the next lesson: : Allergic reactions – causes and mechamisms. Revision of PNS pharmacology - β2 mimetics, parasympatholytics.
  • Week 12
  • H1 ANTIHISTAMINES, TREATMENT OF BRONCHIAL OBSTRUCTION.
  • Classification and clinical use of H1 antihistamines.Sites of action and review of drugs of bronchial obstruction and other drugs acting in respiratory tract.
  • Co-talks.
  • Getting ready for the next lesson: : Drug dosage forms and external routes of drug administration, revision of drug prescription. Revision of prescription of drug dosage forms for external use.
  • Week 13
  • FINAL PRESCRIPTION TEST (includes dermatology).
  • HYPOLIPIDEMICS, THERAPY OF OBESITY.
  • Therapy of hyperlipoproteinaemia and hypercholesterolaemia, review of drugs and their mechanism of action.
  • Getting ready for the next lesson: : Physiology of blood pressure regulation. Revision of PNS pharmacology-α1 sympatotholytics, α2 sympathomimetics, β sympatholytics.
  • Week 14
  • ANTIHYPERTENSIVE AGENTS.
  • Introduction, classification, diuretics, beta blockers, ACE inhibitors, Ca 2+ blockers, and other hypertensives.
  • Co-talks.
  • Getting ready for the next lesson: Revision of lessons 9-14.
  • Week 15
  • REVISING TEST III (Overhead-test with subsequent discussion). Lessons 9 - 14.
  • CASE REPORTS III.
  • Selected case reports on drugs from previous lessons. (including Pharmacology I lessons).
  • CREDITS.
Literature
    required literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
    recommended literature
  • LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
  • HADAŠOVÁ, Eva, Jana NOVÁKOVÁ, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ, Alexandra ŠULCOVÁ and Olga STAROBOVÁ. Praktická cvičení z farmakologie (Practical lessons on pharmacology). 2. opravené a doplněné vyd. Brno: Vydavatelství MU Brno-Kraví Hora, 2003, 110 pp. Skripta. ISBN 80-210-2694-4. info
  • Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    not specified
  • http://portal.med.muni.cz/disciplina-13-farmakologie
  • https://is.muni.cz/auth/el/1411/podzim2008/VLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=VLFA0722p
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
  • http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
  • Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Teaching methods
Drug classes specifics from the Syllabus are firstly briefly reviewed by the teacher, the discussion on possible ambiguities are discussed and learned knowledge is practicesed in case reports from real clinical practice. The training of drug prescription with the use of drug compendia and the computer database of the preparations registered in the Czech Republic (AISLP)follows. Each student prepares a co-talk for specific pharmacological topic.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 4 written tests: a) 1 on special drug presriptions (assessed individually by the teacher), b) 3 x multiple-choice test on knowledge of topics taught (15 questions, number of correct answers indicated). The credits will be given to students who: passed the prescription test and scored at least 6 points from each of multiple-choice tests and their total score from these tests is higher than 20.
Language of instruction
English
Further Comments
The course is taught annually.
Listed among pre-requisites of other courses

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The course is also listed under the following terms spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2018, recent)
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