aZLPF0622p Pathological Physiology II - lecture

Faculty of Medicine
spring 2019
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
MUDr. Kamil Ďuriš, Ph.D. (lecturer)
prof. MUDr. Lydie Izakovičová Hollá, Ph.D. (lecturer)
MUDr. Jan Máchal, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
prof. MUDr. Anna Vašků, CSc. (lecturer)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 16:00–17:40 B11/114, except Tue 7. 5. ; and Tue 7. 5. 16:00–17:40 Kinosál N02901
Prerequisites (in Czech)
aZLPF0521c Pathophysiol.I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train students in dynamic thinking about etiology and pathogenesis of diseases focused on special pathophysiology themes:
Pathophysiology of cardiovascular system.
Pathophysiology of digestive system, nutrition deficits.
Pathophysiology of endocrine system, metabolic diseases.
Pathophysiology of hemopoietic system, neoplasias.
Rheumatic diseases. Immunologically conditioned diseases.
Pathophysiology of respiratory tract.
Pathofphysiology of kidneys, disturbances in metabolism of water and ions.
Pathophysiology of nervous system.
Pathophysiology of muscles and sensory organs.
Learning outcomes
Student will be able:
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to demonstrate the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
- to identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
- todemnostrate the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
- to demonstrate onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
- to describe etiopathogenesis of venous thrombosis using data from experimental animal model;
- to explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
Syllabus
  • 1 19. 2. 2013 Pathophysiology of gastrointestinal system
  • Prof. Kaňková
  • 2 26 .2. 2013 Pathophysiological aspects of chosen allergic and autoimmune diseases
  • Prof. Kaňková
  • 3 5. 3. 2013 Pathophysiology of haematopoiesis
  • Prof. Vašků
  • 4 12. 3. 2013 Pathophysiological aspects of oncologic emergencies
  • Prof. Vašků
  • 5 19. 3. 2013 General pathophysiology of endocrine system.
  • Prof. Vašků
  • 6 26. 3. 2013 Special pathophysiology of endocrine system
  • Prof. Kaňková
  • 7 2. 4. 2013 Pathophysiology of nutrition disorders
  • Prof. Kaňková
  • 8 9. 4. 2013 Pathophysiology of lipid metabolism defects
  • Prof. Vašků
  • 9 16. 4. 2013 Pathophysiological aspects of sugar metabolism defects. Diabetes mellitus.
  • Prof. Kaňková
  • 10 23 .4. 2013 Pathophysiology of bone and muscles
  • Prof. Vašků
  • 11 30. 4. 2013 Pathophysiology of vitamins
  • Prof. Vašků
  • 12 7. 5. 2013 Pathophysiology of coagulation and anticoagulation therapy
  • Prof. Vašků
  • 13 14. 5. 2013 Pathophysiology of nervous system: motoric system
  • Prof. Vašků
  • 14 21. 5. 2013 Pathophysiology of nervous system: degenerative disorders
  • Prof. Vašků
  • 15 28. 5. 2013 DNA diagnostics in complex diseases. Basic principles of pharmacogenomics and personalized medicine.
  • Prof. Vašků Prof. Kaňková 10 23 .4. 2013 Pathophysiology of bone and muscles Prof. Vašků 11 30. 4. 2013 Pathophysiology of vitamins Prof. Vašků 12 7. 5. 2013 Pathophysiology of coagulation and anticoagulation therapy Prof. Vašků 13 14. 5. 2013 Pathophysiology of nervous system: motoric system Prof. Vašků 14 21. 5. 2013 Pathophysiology of nervous system: degenerative disorders Prof. Vašků 15 28. 5. 2013 DNA diagnostics in complex diseases. Basic principles of pharmacogenomics and personalized medicine. Prof. Vašků Prof. Kaňková 10 23 .4. 2013 Pathophysiology of bone and muscles Prof. Vašků 11 30. 4. 2013 Pathophysiology of vitamins Prof. Vašků 12 7. 5. 2013 Pathophysiology of coagulation and anticoagulation therapy Prof. Vašků 13 14. 5. 2013 Pathophysiology of nervous system: motoric system Prof. Vašků 14 21. 5. 2013 Pathophysiology of nervous system: degenerative disorders Prof. Vašků 15 28. 5. 2013 DNA diagnostics in complex diseases. Basic principles of pharmacogenomics and personalized medicine. Prof. Vašků
Literature
    required literature
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, 379 s. ISBN 9788024606750. info
  • NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. ISBN 80-246-0051-X. info
Teaching methods
Lecture.
Assessment methods
Oral exam. The final exam is oral; student will answer 4 questions selected by lot from general, special pathophysiology, practicals and lectures. Individual evaluation from practicals (described by assistant) is taken into account.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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The course is also listed under the following terms Spring 2018, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2019, recent)
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