LF:BLBC0211p Biochemistry -lect. - Course Information
BLBC0211p Biochemistry - lecture
Faculty of Medicinespring 2020
- Extent and Intensity
- 2/0/0. 3 credit(s). Type of Completion: zk (examination).
- Teacher(s)
- doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
MUDr. Michaela Králíková, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant) - Guaranteed by
- prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Monika Šudáková
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine - Timetable
- Wed 8:00–9:50 B22/116 aula, except Wed 20. 5.
- Prerequisites (in Czech)
- BLLC0111s Med.Chem.-seminar && BLLC0111c Medical Chemistry -p
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Medical Laboratory Technologist (programme LF, B-LABD)
- Laboratory Assistant (programme LF, B-SZ)
- Course objectives
- The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.
- Learning outcomes
- In the end of the course will students understand the properties and function of enzymes
Describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships.
Understand the principles of energy production, utilization and deposition at the cellular level.
Explain the function of cell membranes and the principle of compartmentalization at the cellular level and the transport processes on the membrane.
Describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications. Understand the relationship between protein structure and function.
Explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
Discusses the principles of some diseases at the molecular level. - Syllabus
- Enzymes. Characteristic features of biocatalysis, enzyme structure and function, nomenclature and classification of enzymes. Enzyme cofactors, review of structures and functions. Mechanisms of enzyme action. Kinetics of enzyme catalyzed reactions. Assays of enzyme activity, the conditions used. Factors affecting catalytic aktivity of enzymes, types of enzyme inhibition. Metabolism: basic concepts and design. Biological oxidations, generation of high-energy compounds. The citric acid cycle. Oxidative phosphorylation - mitochondrial electron transport chain, synthesis of ATP. Saccharide metabolism: the glycolytic pathway and aerobic decarboxylation of pyruvate. Gluconeogenesis. Glycogen biosynthesis and breakdown. The pentose phosphate pathway. The glucuronate pathway. Interconversions of monosaccharides and of their derivatives. Protein and amino acid metabolism. The common reactions in amino acid degradation. The ureosynthetic cycle. Metabolic breakdown of individual amino acids. Biosynthesis and breakdown of fatty acids, ketogenesis. Synthesis of triacylglycerols. Metabolism of phospholipids and glycolipids. Synthesis of eicosanoids. Biosynthesis and transformations of cholesterol, biosynthesis of bile acids. Interrelationships among the major pathways involved in energy metabolism. Synthesis of haem. Structure of haemoglobin, structure-function relationships (the oxygen saturation curve, inducement of haemoglobin saturation and oxygen transport. Bohr effect. Normal haemoglobin types in blood, haemoglobin concentration. Other forms (glycohaemoglobin, methaemoglobin, carboxyhaemoglobin) and abnormal haemoglobins. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Chromatin, DNA replication. DNA transcription. Regulation of gene expression. Protein synthesis and post-translational processing.
- Literature
- required literature
- KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
- Podklady k přednáškám v IS.
- Teaching methods
- Teaching form are lectures. Supplementary subjects are seminars BLBC021s and practicals BLBC021c.
- Assessment methods
- Course is completed by oral examination. Student must have course-unit credits of both paralel courses in the day of exam.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- Information on completion of the course: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie
The course is taught annually.
Information on the extent and intensity of the course: 30.
Information on course enrolment limitations: Přihlášení ke zkoušce je podmíněno vykonáním zkoušky z Lékařské chemie. - Listed among pre-requisites of other courses
- Enrolment Statistics (spring 2020, recent)
- Permalink: https://is.muni.cz/course/med/spring2020/BLBC0211p